PADN to Treat Severe Obstructive Sleep Apnea (PADN-OSA)
Obstructive Sleep Apnea Syndrome
About this trial
This is an interventional treatment trial for Obstructive Sleep Apnea Syndrome
Eligibility Criteria
Inclusion Criteria:
- Apnea hypopnea index more than 30, not tolerated or refused continuous positive airway pressure;
Exclusion Criteria:
- Acute coronary syndrome;
- Pregnant;
- Expected life less than 12 months;
Sites / Locations
- Nanjing First Hospital
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Experimental
Sham procedure
Pulmonary Arterial Denervation
Patients in the sham group will take sham procedure like PADN.
Contrast pulmonary artery (PA) angiography was performed to localize the pulmonary artery bifurcation level and calculate the PA diameter.Once the anatomy was deemed acceptable, the radiofrequency ablation catheter was introduced into the distal bifurcation area of the main PA.This was then maneuvered within the PA to allow energy delivery to ensure that the electrodes were tightly in contact with the endovascular surface. About two to three ablations at 1-15 W for 240 seconds each point were performed in the distal bifurcation area of the main PA.