Prophylaxis for Aspiration of Gastric Contents.
Pulmonary Aspiration of Gastric Contents
About this trial
This is an interventional prevention trial for Pulmonary Aspiration of Gastric Contents focused on measuring g a, bile reflux. PPIs, H2RAs, prokinetic agents
Eligibility Criteria
Inclusion Criteria: ASA I and II aged 15-70 years
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Exclusion Criteria:
Patients with upper gastrointestinal disorders, Body mass index above 35 kg/m2, Receiving medicines known to effect the secretory and or motor functions of stomach, Had undergone surgery on stomach, With difficult intubation Intestinal obstruction, Partuients and Diabetes
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Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Placebo Comparator
Active Comparator
Active Comparator
Active Comparator
Other
Group C (placebo)
Either PPIs or H2RAs
Either PPIs or H2RAs+prokinetics
Either PPIs or H2RAs+Prokinetic
Intervention Orogastric intubation
Drug intervention Two doses of Placebo at 8.00 pm and then at 6.00 am Group C (placebo) Group C (placebo) Group C (placebo) Group C (placebo) Group C (placebo) Group C (placebo) Group C (placebo) Group C (placebo) Group C (placebo) Group C (placebo)
Drug Intervention Two doses at 8.00 pm and then at 6.00 am Group L (lansoprazole 15 mg) Group E(esomeprazole 20 mg) Group P (pantoprazole 20 mg) Group R (rabeprazole 10 mg) Group O (omeprazole 20 mg) Group T (cimetidine 200 mg) Group F (famotidine 20 mg) Group N (nizatidine 150 mg) Group Z (ranitidine 150 mg) Group S (lafutidine 10 mg)
Drug intervention Two doses at 8.00 pm and then at 6.00 am Group L D (lansoprazole 15 mg+ domperidone 10 mg) Group EM (esomeprazole 20 mg+metoclopramide 10 mg) Group PD (pantoprazole 20 mg+domperidone 10) Group RM (rabeprazole 10 mg+metoclopramide 10 mg) Group OD (omeprazole 20 mg+domperidone 10) Group TD (cimetidine 200 mg+domperidone 10) Group FM (famotidine 20 mg+metoclopramide 10 mg) Group NM (nizatidine 150 mg+metoclopramide 10 mg) Group ZD (ranitidine 150 mg+ domperidone 10 mg) Group SD (lafutidine 10 mg+domperidone 10 mg)
Drug intervention Two doses at 8.00 pm and then at 6.00 am Group OM (omeprazole 20 mg +metoclopramide 10 mg) Group SM (lafutidine 10 mg + metoclopramide 10 mg )
After general anesthesia, an oro-gastric tube was inserted through another endotracheal tube placed in upper esophagus into the stomach for aspiration of gastric contents.