Genotyping Influences Outcome of Coronary Artery Stenting (GENIUS)

Prospective Multi-center Registry of Genotyping Related Clopidogrel in Percutaneous Coronary Intervention Patients

This study evaluated epidemiology and clinical outcome of clopidogrel related various genotyping in Korean patients who had undergone percutaneous coronary intervention as a all comer registry form.

This study evaluates the relationship between clopidogrel related various genotyping, epidemiology and clinical outcome of patient who had undergone percutaneous coronary intervention. Clopidogrel resistance was measured with VerifyNow, which is a device that can monitor platelet inhibition of clopidogrel. Genes which are known to be related with clopidogrel resistance were evaluated; (1-3) CYP 2C19 *2, *3, *17, (4) PON1 Q192R, (5) ABCB1 3435C->T, (6) P2Y12, (7) CYP 2C9 *3.

All comer patients who had undergone percutaneous coronary intervention with administration of conventional dual anti-platelet treatment (aspirin 100mg and clopidogrel 75mg daily) for minimum 3 months

Administration of conventional dual anti-platelet treatment (aspirin 100mg and clopidogrel 75mg daily) for minimum 3 months after percutaneous coronary intervention

Revascularization of in-stent restenosis which developed in previously implanted stent on index procedure

Ischemic or hemorrhagic cerebral infarction diagnosed by brain MRI which developed within 1 year after index procedure

Inclusion Criteria: Written informed consent Older than 20 years All percutaneous coronary intervention patients within 1 month Exclusion Criteria: Pregnancy Life expectancy below 1 year Known aspirin or clopidogrel allergy

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