Randomized Phase 2 Study of Atezolizumab and Entinostat in Patients With aTN Breast Cancer With Phase 1b Lead In
Breast Cancer

About this trial
This is an interventional treatment trial for Breast Cancer
Eligibility Criteria
Inclusion Criteria:
- Has histologically or cytologically confirmed triple negative breast carcinoma that is either metastatic (stage IV of the TNM classification) or locally recurrent and not amenable to local curative treatment.
- Evidence of measurable, locally recurrent or metastatic disease based on imaging studies within 28 days before the first dose of study drug.
- Has received at least 1, but no more than 2, prior lines of systemic therapy for locally recurrent and/or metastatic disease.
- If patient has a history of treated asymptomatic CNS metastases they are eligible, provided they meet all of the following criteria: Patient has measurable disease outside CNS; Patient does not have metastases to midbrain, pons, medulla or spinal cord; Patient is not on corticosteroids as therapy for CNS disease (anticonvulsants at a stable dose are allowed); Patient has not had whole-brain radiation within 6 weeks prior to study enrollment; Patient has stable CNS disease as demonstrated by at least 4 weeks of stability between the last intervention scan and the study screening scan.
- ECOG performance status of 0 or 1.
- Has acceptable, applicable laboratory parameters.
- Female subjects must not be pregnant; willing to use 2 methods of birth control/abstinence if applicable through 120 days after the last dose of study drug.
- Experienced resolution of toxic effect(s) of the most recent prior anti-cancer therapy to Grade <1 (except alopecia or neuropathy).
- Able to understand and give written informed consent and comply with study procedures.
Exclusion Criteria:
- Diagnosis of immunodeficiency or receiving systemic steroid therapy or any other form of immunosuppressive therapy within 7 days prior to the first dose of study drug.
- Active autoimmune disease including active diverticulitis, symptomatic peptic ulcer disease, colitis, or inflammatory bowel disease that has required systemic treatment in past 2 years.
- Previously treated with a PD-1/PD-L1-blocking antibody or a histone deacetylase inhibitor.
- History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the treating Investigator, including, but not limited to: History of immune deficiencies or autoimmune disease; Myocardial infarction or arterial thromboembolic events within 6 months prior to screening or severe or unstable angina, New York Heart Association (NYHA) Class III or IV disease, or a QTc interval > 470 msec; Uncontrolled hypertension or diabetes mellitus; Another known malignancy that is progressing or requires active treatment; Active infection requiring systemic therapy; Known active central nervous system (CNS) metastases and/or carcinomatous meningitis.
- Any contraindication to oral agents or significant nausea and vomiting, malabsorption, or significant small bowel resection that, in the opinion of the investigator, would preclude adequate absorption.
- Received a live vaccine within 30 days of the first dose of treatment.
- Prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to enrollment or who has not recovered from AEs due to mAb agents administered more than 4 weeks earlier.
- Prior chemotherapy within 3 weeks, targeted small molecule therapy or radiation therapy within 2 weeks prior to enrollment, or who has not recovered (i.e., ≤Grade 1 at enrollment) from AEs due to a previously administered agent.
- Received transfusion of blood products or administration of colony stimulating factors within 4 weeks prior to the first dose of treatment.
- Currently participating and receiving study therapy or has participated in a study of an investigational agent and received study therapy or used an investigational device within 4 weeks of the first dose of study drug.
- Currently receiving treatment with any other agent listed on the prohibited medication list.
- If female, is pregnant, breastfeeding, or expecting to conceive starting with the screening visit through 120 days after the last dose of study drug.
- Known history of human immunodeficiency virus (HIV) (HIV 1/2 antibodies).
- Known active hepatitis B or hepatitis C.
- Allergy to benzamide or inactive components of entinostat.
- History of allergies to any active or inactive ingredients of atezolizumab.
- Known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the study.
Sites / Locations
- UAB Comprehensive Cancer Center
- CBCC Global Research at Comprehensive Blood and Cancer Center
- St. Jude Medical Center
- Los Angeles Hematology Oncology Medical Group
- Torrance Memorial Cancer Care Associates
- SLO Oncology and Hematology Health Center
- Central Coast Medical Oncology Group
- UCLA Hematology/Oncology - Santa Monica
- Saint Mary's Regional Cancer Center
- Office of Human Research
- Orlando Health, Inc.
- Ft. Wayne Hematology and Oncology
- Ft. Wayne Medical Oncology & Hematology, Inc
- Cancer Center of Kansas
- Frauenshuh Cancer Center at Park Nicollet Health Service
- Saint Barnabas Medical Cancer Center
- Hope Women's Cancer Centers
- Wake Forest Baptist Medical Center
- Texas Oncology-Baylor Charles A. Sammons Cancer Center
- Cancer Center of Adjara Autonomous Republic
- Saint Nikolozi Surgery and Oncological Centre
- Unimed Adjara - Oncology Center
- Health House
- Institute of Clinical Oncology
- New Vision University Hospital
- Cancer Research Center
- S. Khechinashvili, University Hospital
- Multiprofile Clinic Consilium Medulla
- Research Institute of Clinical Medicine
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Entinostat plus Atezolizumab
Placebo plus Atezolizumab
Participants in this arm will receive entinostat in combination with atezolizumab. Phase 1b Dose Determination: The initial 3 to 6 participants will receive entinostat at a starting dose of 5 milligrams (mg) (Dose Group 1) on Days 1, 8, and 15 along with atezolizumab 1200 mg via intravenous (IV) infusion on Day 1 of each 21-day cycle. If the 5 mg dose exceeds the maximum tolerated dose (MTD), then a 3 mg dose of entinostat (Dose Group -1) will be evaluated in the same manner. If the -1 dose level exceeds the MTD, then a 2 mg dose of entinostat (Dose Group -2) will be evaluated. Phase 2 Dose Expansion: Participants will receive the RP2D identified in the Dose Determination Phase.
Participants in this arm will receive placebo in combination with atezolizumab 1200 mg.