Efficacy of Rechallenge With Sunitinib in Metastatic Pancreatic Neuroendocrine Tumor Previously Failed to Sunitinib (RESUNET)

This is an interventional treatment trial for Pancreatic Neuroendocrine Tumour Metastatic focused on measuring Sunitinib Read More

Inclusion Criteria:

• Subjects > 18 years old and able to give their informed consent.
• Patients diagnosed with Neuroendocrine Tumor of pancreatic origin and histologically confirmed, G1/2 according to the World Health Organization (WHO) classification (Ki67 <20% and/or mitotic count >20 mitoses x 10 HPF).
• Metastatic disease progression in the 12 months prior to baseline visit documented by CT, MRI or Octreoscan.
• Progression to prior treatment with sunitinib administered for metastatic disease and have received at least 1 line and no more than 2 lines of subsequent systemic treatment.
• Measurable disease according to the following criteria RECIST version 1.1
• No disease that can be treated with surgery, radiotherapy or combined treatment with curative intent.
• Eastern Cooperative Oncology Group (ECOG) 0-2.
• Pretreatment with somatostatin analogues, chemotherapy, anti-VEGF (vascular endothelial growth factor) and mTOR (mammalian target of rapamycin) inhibitors prior to participation in the study is allowed.
• Adequately controlled blood pressure (BP) <150/90 mmHg.
• Hematologic Function: - Absolute neutrophil count >1500 / microliter (uL) - Platelets >100,000 / uL - Hemoglobin >5.6 mmol / L (9 g / dL)
• Liver function: total bilirubin < 1.5 x upper limit of normal (ULN), unless unconjugated hyperbilirubinemia or Gilbert syndrome. - Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) < 2.5 x ULN (< 5 times in case of liver metastases).
• Renal function: calculated creatinine clearance according to Cockcroft-Gault > 30 ml / min.
• Blood coagulation: prothrombin time (PT) or International Normalized Ratio (INR) < 1.2 x ULN.
• Proteinuria <2+ urine dipstick. If > 2+ proteinuria, urinary protein <1 g / 24 h.
• Life expectancy> 3 months.
• Patient able to swallow the study drug and comply with the monitoring requirements of the study. - Women of childbearing potential must present a negative pregnancy test. Women of childbearing potential must agree to use contraception.
• Men whose partners are women of childbearing potential must use effective contraception.

Exclusion Criteria:

• Neuroendocrine tumors of pancreatic origin G3 according to WHO classification.
• Patients who received 3 or more lines of systemic treatment.
• Major surgery or trauma within 4 weeks prior to the first dose of sunitinib.
• Radiation therapy or tumor embolization within 2 weeks prior to the first dose of sunitinib.
• Chemotherapy, immunotherapy, biologic therapy or investigational therapy within the previous 2 weeks or 5 half-lives of the drug last received before the start of the first dose of sunitinib treatment.
• Prior treatment with high-dose chemotherapy that required hematopoietic rescue.
• Immunosuppressive therapy or prolonged treatment with corticosteroids concomitantly administered in the previous 3 months.
• Resolution to grade <2 (CTCAE according V4.03) of all previous related toxicities except alopecia treatments.
• Any ongoing toxicity from prior anti-cancer therapy that is >Grade 1 (according CTCAE V4.03) and/or that is progressing in severity, except alopecia.
• Treatment with potent inhibitors or inducers of CYP3A4 or known to prolong the QT interval in the previous 7 days.
• Prior radiotherapy to more than 25% of the bone marrow - Presence of uncontrolled metastatic brain disease, spinal cord compression, meningeal carcinomatosis or leptomeningeal disease.
• Any gastrointestinal malabsorption disorder or any other condition that, at investigator's criteria, may affect the absorption of sunitinib or increase the risk of bleeding or perforation.
• Presence of any non-healing wound or ulcer.
• Grade III/IV diarrhea in the screening period.
• Diagnosis of any second malignancy within the last 5 years, except for adequately treated basal cell or squamous cell skin cancer, or in situ carcinoma of the cervix uteri.
• Clinically significant cardio/cerebrovascular disease in the 6 months prior to treatment.
• Cardiac arrhythmias (NCI CTCAE version 4.0 grade >2), atrial fibrillation of any grade that requires medical treatment.
• Corrected QT interval (QTcF) > 180 msec.
• Active hemoptysis in the past 6 weeks.
• Evidence of active bleeding or bleeding diathesis.
• Presence of endobronchial lesions and/or lesions that infiltrate large vessels.
• Current treatment with acenocoumarol at therapeutic doses.
• Known HIV infection.
• Presence of uncontrolled active infection.
• Pregnant or breastfeeding women.
• Previous allergic reaction to components structurally similar to sunitinib or any of the excipients.
• Inability to discontinue any prohibited concomitant medication.
• Any illness (medical or psychiatric) or reason, in the investigator's opinion, that interferes with the patient's ability to participate.