Early Amniotic Membrane Transplantation in Bacterial Keratitis
Keratitis of Both Eyes
About this trial
This is an interventional treatment trial for Keratitis of Both Eyes focused on measuring keratitis, AMT, bacterial keratitis, medication
Eligibility Criteria
Inclusion Criteria:
Bacterial keratitis being in the first week of diagnosis medically undergoing treatment
Exclusion Criteria:
thinning limbal extension intraocular extension underlying disease Nocardia keratitis
Sites / Locations
Arms of the Study
Arm 1
Arm 2
No Intervention
Active Comparator
Non AMT
AMT
Freshly prepared fortified eye drops (cefazolin 50 mg/mL and amikacin 14 mg/mL) were applied as starting treatment. In the first 3 days, eye drops are applied round the clock followed by drops every 2 h during waking hours until results of laboratory investigation were available. After preparation of the culture results, the antimicrobial treatment was narrowed according to bacterial sensitivity. Also topical betamethasone 0.1% four times a day on a tapering weekly dosage until 3-4 weeks is used for all patients. If the patient underwent any tectonic procedure during the treatment such as keratoplasty, cyanoacrylate glue are documented
This group (case group) received above mentioned routine antibiotic therapy followed by double-layer amniotic membrane transplantation 2-5 days after the start of medications and the second group (control group) only received routine antibacterial therapy. The AM was trimmed in two layers to fit the corneal ulcer and was placed with its epithelium (basement membrane) side up, secured with 10/0 nylon sutures, supported by a therapeutic contact lens. If the patient underwent any tectonic procedure during the treatment such as keratoplasty, cyanoacrylate glue are documented.