Hyaluronan-enriched Embryo Transfer Medium for Frozen-thawed Embryo Transfer
In Vitro Fertilization, Subfertility
About this trial
This is an interventional treatment trial for In Vitro Fertilization
Eligibility Criteria
Inclusion Criteria:
- Women panning to replacing early cleavage embryos or blastocysts after thawing.
Exclusion Criteria:
- Frozen early cleavage embryos thawed and cultured to blastocysts prior to transfer as requested by the patient
- Preimplantation genetic diagnosis treatment
- Use of donor oocytes or donor embryos
- Endometrial thickness <8mm on the day of the luteinizing hormone surge or after two weeks of estrogen in hormonal replacement cycles
- Hydrosalpinx shown on pelvic scanning and not surgically treated
Sites / Locations
- Kwong Wah Hospital
- Queen Mary Hospital, University of Hong Kong
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
HA group
Control group
One the day of frozen-thawed embryo transfer, frozen embryos will be thawed and incubated for at least 10 minutes in embryo transfer medium. For women allocated to the HA group, EmbryoGlue (Vitrolife), a hyaluronan-enriched embryo transfer medium, will be used as embryo transfer medium. EmbryoGlue contains a higher concentration of hyaluronan than the control medium.
For women allocated to the control group, the usual transfer medium used in the study centers will be used and will serve as control. The main difference between the two media is that EmbryoGlue contains a higher concentration of HA.