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Apatinib as Second-line Treatment of Advanced Pancreatic Cancer (Apslpanc)

Primary Purpose

Pancreatic Neoplasms

Status
Unknown status
Phase
Phase 2
Locations
China
Study Type
Interventional
Intervention
Apatinib
Sponsored by
First Affiliated Hospital Xi'an Jiaotong University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Pancreatic Neoplasms

Eligibility Criteria

18 Years - 70 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • ≥ 18 and ≤ 70 years of age,Male or female;
  • The advanced pancreatic cancer pathology, with measurable lesions (spiral CT scan is more than 10mm, according to the standard of RECIST 1.1);
  • Locally advanced, unresectable recurrent or metastatic pancreatic cancer;
  • According to CTCAE 4.0 and patient complaints, the researchers determine second-line chemotherapy should not be tolerated by the patients or patients want to receive second-line chemotherapy.
  • ECOG performance scale 0-1;
  • Baseline blood routine and biochemical indexes meet the following criteria:
  • Hemoglobin ≥ 80g/L,
  • The absolute neutrophil count (ANC) ≥ 1.5 ×109/L,
  • Blood platelet ≥ 90 ×109/L
  • Alanine aminotransferase(ALT),Aspartate transaminase (AST) less than 2.5 times the upper limit of normal value, equal to or less than 5 times the upper limit of normal (liver metastasis),
  • the serum total bilirubin is less than 1.5 times the upper limit of normal value,
  • Serum creatinine. Less than 1.5 times the upper limit of normal value,
  • Serum albumin is more than 30g/L;
  • Life expectancy ≥ 3 months.
  • women of childbearing age to within 7 days before entering the group of serum or urine pregnancy test and the results were negative. And be willing to give drug test during the test and the last 8 weeks using an appropriate method of contraception. For men, for sterilization, or agreed to during the period of the experiment and at the end of the given experimental drugs for 8 weeks by appropriate methods of contraception;
  • In this study, volunteer subjects signed the informed consent, good compliance with follow-up.

Exclusion Criteria:

  • It is confirmed that of apatinib and / or its accessories allergy;
  • Have high blood pressure and antihypertensive drug treatment can not drop to normal range(systolic pressure >140 mmHg, diastolic blood pressure 90>mmHg), suffering from coronary artery disease above grade I, grade I arrhythmia (including corrected QT interval prolongation male > 450 ms, women > 470 MS) and grade I heart insufficiency; urine protein positive patients.
  • Has a variety of factors influencing oral drugs (such as unable to swallow, nausea, vomiting, chronic diarrhea and intestinal obstruction, etc.);
  • Coagulant function abnormality (INR>1.5, activated partial thromboplastin time(APTT)>1.5, ULN) with bleeding tendency;
  • patients with central nervous system metastasis;
  • pregnant or lactating women;
  • Patients with other malignant tumors within five years;
  • Has a history of psychiatric drugs abuse and can't quit or patients with mental disorders;
  • 4 weeks participated in other clinical trials of patients;
  • received VEGFR inhibitors, such as sorafenib, chougny for treatment;
  • According to the researcher's judgment, there is serious to endanger the safety of patients or affect patients with disease to do the research;
  • The researchers think that the person doesn't fit into.

Sites / Locations

  • First affiliate hospital of Xi'an Jiaotong UniversityRecruiting

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

Apatinib

Arm Description

Patients will be offered with Apatinib (850mg daily,orally)until their disease have progressed.

Outcomes

Primary Outcome Measures

PFS(Progression free survival)
ORR (Objective response rate)

Secondary Outcome Measures

DCR(disease control rate)
OS (Overall survival)
QoL (Quality of life as assessed by EORTC QLQ-C30)
Number of participants with treatment-related adverse events as assessed by NCI-CTC(V3.0)

Full Information

First Posted
March 16, 2016
Last Updated
November 30, 2016
Sponsor
First Affiliated Hospital Xi'an Jiaotong University
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1. Study Identification

Unique Protocol Identification Number
NCT02726854
Brief Title
Apatinib as Second-line Treatment of Advanced Pancreatic Cancer
Acronym
Apslpanc
Official Title
Apatinib as Second-line Treatment of Advanced Pancreatic Cancer, Phase II Clinical Study of Open Arm
Study Type
Interventional

2. Study Status

Record Verification Date
November 2016
Overall Recruitment Status
Unknown status
Study Start Date
April 2016 (undefined)
Primary Completion Date
December 2017 (Anticipated)
Study Completion Date
December 2017 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
First Affiliated Hospital Xi'an Jiaotong University

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The main research purpose Evaluation of objective response Apatinib second-line treatment of advanced pancreatic cancer (ORR) and the rate of progression free survival (PFS). Objective to study the objective and exploratory secondary research To observe the Apatinib in second line treatment of advanced pancreatic cancer disease control rate (DCR), patients with overall survival (OS) benefit, treatment effects on quality of life (QOL) score and drug safety evaluation, To investigate the relationship of apatinib as second-line treatment of advanced pancreatic cancer and the expression of vascular endothelial growth factor receptor(VEGFR) in the serum
Detailed Description
The purpose of this study is to determine what effects apatinib has on advanced pancreatic cancer patients after failure of first-line chemotherapy cannot tolerate second-line chemotherapy or unwilling to receive second-line chemotherapy of pancreatic cancer patients.To investigate the relationship between apatinib as second-line treatment of advanced pancreatic cancer and the expression of vascular endothelial growth factor receptor(VEGFR) in the serum. This study choose the First Affiliated Hospital of Xi'an JiaoTong University were unable to tolerate the failure of first-line chemotherapy for second-line chemotherapy or unwilling to receive second-line chemotherapy of pancreatic cancer patients as the research object, the clinical data of clinical subjects age and sex, Eastern Cooperative Oncology Group (ECOG) score, tumor stage, pathological type, pathological grading, giving apatinib treatment, during the treatment of blood monitoring in patients with CA199 levels, imaging findings, assessment of tumor related symptoms and adverse events, and the expression of VEGFR in blood was measured by ELISA method, the curative effect evaluation of the end of the 2 cycle of treatment, patients with effective evaluation to oral apatinib, through the statistical analysis of the data of complete remission (CR) or partial remission (PR), the rate of progression free survival (PFS) expression of CA199 content in serum and serum VEGFR levels of the relevant indicators,. Explore Apatinib for the curative effect and safety of the second-line treatment of advanced pancreatic cancer, and to explore the relationship between the serum VEGF expression level.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Pancreatic Neoplasms

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 2
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
30 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Apatinib
Arm Type
Experimental
Arm Description
Patients will be offered with Apatinib (850mg daily,orally)until their disease have progressed.
Intervention Type
Drug
Intervention Name(s)
Apatinib
Other Intervention Name(s)
YN968D1
Intervention Description
Patients with pancreatic cancer who are failed of receiving first-line chemotherapy and cannot tolerate second-line chemotherapy or unwilling to receive second-line chemotherapy will receive Apatinib Tablets (850mg once daily, orally) 30 minutes after meal with warm water. Take 28 days as a cycle, patients will receive this treatment until they have got disease progressed.
Primary Outcome Measure Information:
Title
PFS(Progression free survival)
Time Frame
8 Weeks
Title
ORR (Objective response rate)
Time Frame
8 Weeks
Secondary Outcome Measure Information:
Title
DCR(disease control rate)
Time Frame
8 Weeks
Title
OS (Overall survival)
Time Frame
8 Weeks
Title
QoL (Quality of life as assessed by EORTC QLQ-C30)
Time Frame
8 Weeks
Title
Number of participants with treatment-related adverse events as assessed by NCI-CTC(V3.0)
Time Frame
8 Weeks

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
70 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: ≥ 18 and ≤ 70 years of age,Male or female; The advanced pancreatic cancer pathology, with measurable lesions (spiral CT scan is more than 10mm, according to the standard of RECIST 1.1); Locally advanced, unresectable recurrent or metastatic pancreatic cancer; According to CTCAE 4.0 and patient complaints, the researchers determine second-line chemotherapy should not be tolerated by the patients or patients want to receive second-line chemotherapy. ECOG performance scale 0-1; Baseline blood routine and biochemical indexes meet the following criteria: Hemoglobin ≥ 80g/L, The absolute neutrophil count (ANC) ≥ 1.5 ×109/L, Blood platelet ≥ 90 ×109/L Alanine aminotransferase(ALT),Aspartate transaminase (AST) less than 2.5 times the upper limit of normal value, equal to or less than 5 times the upper limit of normal (liver metastasis), the serum total bilirubin is less than 1.5 times the upper limit of normal value, Serum creatinine. Less than 1.5 times the upper limit of normal value, Serum albumin is more than 30g/L; Life expectancy ≥ 3 months. women of childbearing age to within 7 days before entering the group of serum or urine pregnancy test and the results were negative. And be willing to give drug test during the test and the last 8 weeks using an appropriate method of contraception. For men, for sterilization, or agreed to during the period of the experiment and at the end of the given experimental drugs for 8 weeks by appropriate methods of contraception; In this study, volunteer subjects signed the informed consent, good compliance with follow-up. Exclusion Criteria: It is confirmed that of apatinib and / or its accessories allergy; Have high blood pressure and antihypertensive drug treatment can not drop to normal range(systolic pressure >140 mmHg, diastolic blood pressure 90>mmHg), suffering from coronary artery disease above grade I, grade I arrhythmia (including corrected QT interval prolongation male > 450 ms, women > 470 MS) and grade I heart insufficiency; urine protein positive patients. Has a variety of factors influencing oral drugs (such as unable to swallow, nausea, vomiting, chronic diarrhea and intestinal obstruction, etc.); Coagulant function abnormality (INR>1.5, activated partial thromboplastin time(APTT)>1.5, ULN) with bleeding tendency; patients with central nervous system metastasis; pregnant or lactating women; Patients with other malignant tumors within five years; Has a history of psychiatric drugs abuse and can't quit or patients with mental disorders; 4 weeks participated in other clinical trials of patients; received VEGFR inhibitors, such as sorafenib, chougny for treatment; According to the researcher's judgment, there is serious to endanger the safety of patients or affect patients with disease to do the research; The researchers think that the person doesn't fit into.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Danfeng Dong, MD
Phone
008615349257340
Email
qiwudanfeng@sina.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Enxiao Li, MD
Organizational Affiliation
First Affiliated Hospital Xi'an Jiaotong University
Official's Role
Study Chair
Facility Information:
Facility Name
First affiliate hospital of Xi'an Jiaotong University
City
Xi'an
State/Province
Shaanxi
ZIP/Postal Code
710061
Country
China
Individual Site Status
Recruiting
Facility Contact:
Phone
2982655038
First Name & Middle Initial & Last Name & Degree
China
Phone
2982655038

12. IPD Sharing Statement

Plan to Share IPD
Undecided

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Apatinib as Second-line Treatment of Advanced Pancreatic Cancer

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