Aerobic Dance Training in Small Vessel Disease (ADTSVD)
Cerebrovascular Disease
About this trial
This is an interventional prevention trial for Cerebrovascular Disease focused on measuring Cerebral small vessel disease, Lifestyle modification, Physical activity, Primary prevention, Aerobic dance, Cognition, Depression, Activities of daily living, Cerebral autoregulation
Eligibility Criteria
Inclusion Criteria:
- Age ≥65
- Community dwelling
- Presence of significant SVD, defined by the presence of multiple (≥2) lacunar infarcts and/or a rating of ≥2 (i.e. beginning confluence of lesions to diffuse involvement of lesions in periventricular and/or deep white matter) of WML using the Age-related White Matter Changes (ARWMC) Scale on MRI
- Presence of good temporal window on at least one side for TCD evaluation
- Written informed consent given
Exclusion Criteria:
- History of stroke
- Dementia, determined by a score on Cantonese MMSE less than education adjusted cutoff score for dementia or history of dementia diagnosis
- Comorbidity with medical conditions affecting the central nervous system or cerebral white matter
- Inadequately controlled psychiatric disorders affecting cognition and mood
- Physical or sensory impediments hindering participation in cognitive assessment or exercise training.
Sites / Locations
- Chinese University of Hong KongRecruiting
- Neurology Clinical Research Centre, CUHK
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Structured Aerobic Dance Training Group
Stretching plus education
Active intervention will last for 24 weeks and consists of 60-minute/session, which includes 10 minutes warm-up, 40 minutes of dancing and 10 minutes of cool down. In groups of 5, participants will practice the dance led by a physiotherapist once per week for the first 2 months and twice per week for 3rd to 6th month.
Participants in the control group will receive a weekly 3-hour group-based (group of 5 participants) programme containing stretching exercise, stress reduction and health education on dementia and stroke prevention for 6 months. The programme consists of low-intensity seated stretching, psychoeducation on stress management, various relaxation methods with practice as well as education on the causes, identification, treatment and prevention of stroke and dementia. Benefits of physical exercise will also be discussed but will its weight will be evenly balanced with other forms of evidence-based preventive strategies.