Motivation and Executive Control in Schizophrenia
Primary Purpose
Schizophrenia
Status
Completed
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
realization of computerized exercises
Sponsored by
About this trial
This is an interventional basic science trial for Schizophrenia focused on measuring schizophrenia, motivation, executive control
Eligibility Criteria
Inclusion Criteria:
- Age 18-45 years old
- schizophrenia
- french native speaker
Exclusion Criteria:
- Neurological disease
- Motor or visual deficit
- Somatic treatment with neurological impact
- Drug abuse
Sites / Locations
- Professeur FRANCK Nicolas
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Sham Comparator
Arm Label
schizophrenia group
control group
Arm Description
Schizophrenia patients suffering
subjects showing no psychological or neurological disorder
Outcomes
Primary Outcome Measures
reaction time
reaction time is recorded when the subject press the key (subject should press a key function of the characteristics of the letter submitted)Reaction time should vary with the level of executive control (episodic, contextual, and motivation control (episodic or contextual motivation). Responses will be compared across patients and control.
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT02734927
Brief Title
Motivation and Executive Control in Schizophrenia
Official Title
Motivation and Executive Control in Schizophrenia
Study Type
Interventional
2. Study Status
Record Verification Date
April 2018
Overall Recruitment Status
Completed
Study Start Date
November 2012 (Actual)
Primary Completion Date
April 24, 2018 (Actual)
Study Completion Date
April 24, 2018 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Hôpital le Vinatier
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
In order to control a behaviour, investigators need to realise goal directed actions and to priories some actions. This control is required in unusual situation. Appropriate actions are selected and coordinated according to context and aim.
Several studies try to draw a model of executive function. Recently, Koechlin has suggested a three levelled organisation to explain how the prefrontal cortex controls actions.
Contextual control is useful to answer appropriately with the immediate context. Episodic control allows selecting the action according to specific information given before. Sensorial control is the automatic response when a stimulus is presented.
Some diseases like schizophrenia are associated with neurological dysfunction in prefrontal cortex. Chambon and al (2008) have identified a dysfunction of contextual control in schizophrenia.
As the prefrontal cortex is involved in motivational process, it seems interesting to study potential links between executive function and motivation. A study from Kouneiher shows contextual and episodic activation of motivation in healthy population.
Investigators aim to study the way motivational process are recruited in schizophrenia.
Detailed Description
behavioral protocol. Letters (vowel and consonant; upper- or lower- case) are presented in several colours into successive blocks. Each block included a series of eight letters. Each colour required a specific task given by a fixed rule (contextual control) but for some colour, the rule changes sometimes (episodic control). Participants are informed that payoffs vary according to their own performance. A frame indicates essay with bonus reward. Moreover a dashed frame indicates a low-bonus reward and a solid frame means a high-bonus reward. Thus different blocks are designed: low-incentive block and high incentive block.
This reward increased from standard to bonus motivation in high-incentive block (contextual motivation) and from low to high according to the type of blocks (episodic motivation) Reaction time may be higher in bonus reward Patients with schizophrenia are not sensitive to contextual motivation, and therefore patients should behave differently than control in contextual motivation.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Schizophrenia
Keywords
schizophrenia, motivation, executive control
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
41 (Actual)
8. Arms, Groups, and Interventions
Arm Title
schizophrenia group
Arm Type
Active Comparator
Arm Description
Schizophrenia patients suffering
Arm Title
control group
Arm Type
Sham Comparator
Arm Description
subjects showing no psychological or neurological disorder
Intervention Type
Other
Intervention Name(s)
realization of computerized exercises
Primary Outcome Measure Information:
Title
reaction time
Description
reaction time is recorded when the subject press the key (subject should press a key function of the characteristics of the letter submitted)Reaction time should vary with the level of executive control (episodic, contextual, and motivation control (episodic or contextual motivation). Responses will be compared across patients and control.
Time Frame
24 hours
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
45 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Age 18-45 years old
schizophrenia
french native speaker
Exclusion Criteria:
Neurological disease
Motor or visual deficit
Somatic treatment with neurological impact
Drug abuse
Facility Information:
Facility Name
Professeur FRANCK Nicolas
City
Bron
State/Province
Rhone-alpes
ZIP/Postal Code
69678
Country
France
12. IPD Sharing Statement
Plan to Share IPD
No
Learn more about this trial
Motivation and Executive Control in Schizophrenia
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