search
Back to results

The Causative Insects in Severe Insect Sting Allergy

Primary Purpose

Insect Sting Allergy

Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Skin prick test
sIgE measurement
Sponsored by
Mahidol University
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional diagnostic trial for Insect Sting Allergy focused on measuring insect sting allergy, recombinant venom allergen

Eligibility Criteria

undefined - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Cases with severe insect sting allergy reactions

Exclusion Criteria:

  • Without other severe systemic diseases
  • Not pregnant or lactation

Sites / Locations

    Arms of the Study

    Arm 1

    Arm Type

    Other

    Arm Label

    insect sting allergy

    Arm Description

    Skin prick tests to local and imported insect sting allergen with different concentration are performed. sIgE Measurement (to insect and the recombinant venom)

    Outcomes

    Primary Outcome Measures

    Mean wheal diameters of skin prick test of local and imported insect allergens
    Compare Mean wheal diameters of skin prick test of local and imported insect allergens at different concentrations

    Secondary Outcome Measures

    specific IgE level to stinging insect allergen and recombinant venom allergens
    compare skin prick test result and levels of specific IgE level to stinging insect allergen and recombinant venom allergens

    Full Information

    First Posted
    May 4, 2016
    Last Updated
    May 4, 2016
    Sponsor
    Mahidol University
    search

    1. Study Identification

    Unique Protocol Identification Number
    NCT02764242
    Brief Title
    The Causative Insects in Severe Insect Sting Allergy
    Official Title
    Evaluating the Causative Insects in the Cases With Severe Insect Sting Allergy
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    May 2016
    Overall Recruitment Status
    Completed
    Study Start Date
    February 2015 (undefined)
    Primary Completion Date
    March 2016 (Actual)
    Study Completion Date
    April 2016 (Actual)

    3. Sponsor/Collaborators

    Responsible Party, by Official Title
    Principal Investigator
    Name of the Sponsor
    Mahidol University

    4. Oversight

    Data Monitoring Committee
    No

    5. Study Description

    Brief Summary
    Study the causative insect by skin prick test and sIgE to wasp, bee and fire ants are important but false positive by crossreactivity can occur. sIgE to recombinant venom allergen is proposed to help in finding the causative insect.
    Detailed Description
    Insect sting allergy from insects in Hymenoptera is not uncommon. The reaction maybe very severe and life threatening. To find the cause of insect sting allergy is important in prevention and specific treatment such as immunotherapy. The skin prick test and sIgE of these insects may have cross reactions so it is difficult to be interpreted. The usage of sIgE recombinant venom allergen can benefit in separate cross reaction and dual allergy reaction.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Insect Sting Allergy
    Keywords
    insect sting allergy, recombinant venom allergen

    7. Study Design

    Primary Purpose
    Diagnostic
    Study Phase
    Not Applicable
    Interventional Study Model
    Single Group Assignment
    Masking
    None (Open Label)
    Allocation
    N/A
    Enrollment
    20 (Actual)

    8. Arms, Groups, and Interventions

    Arm Title
    insect sting allergy
    Arm Type
    Other
    Arm Description
    Skin prick tests to local and imported insect sting allergen with different concentration are performed. sIgE Measurement (to insect and the recombinant venom)
    Intervention Type
    Other
    Intervention Name(s)
    Skin prick test
    Intervention Description
    Skin prick tests to local and imported insect sting allergen with different concentration are performed.
    Intervention Type
    Other
    Intervention Name(s)
    sIgE measurement
    Intervention Description
    sIgE levels to stinging insect allergen and their recombinant venom allergen are measured
    Primary Outcome Measure Information:
    Title
    Mean wheal diameters of skin prick test of local and imported insect allergens
    Description
    Compare Mean wheal diameters of skin prick test of local and imported insect allergens at different concentrations
    Time Frame
    12 months
    Secondary Outcome Measure Information:
    Title
    specific IgE level to stinging insect allergen and recombinant venom allergens
    Description
    compare skin prick test result and levels of specific IgE level to stinging insect allergen and recombinant venom allergens
    Time Frame
    12 months

    10. Eligibility

    Sex
    All
    Accepts Healthy Volunteers
    No
    Eligibility Criteria
    Inclusion Criteria: Cases with severe insect sting allergy reactions Exclusion Criteria: Without other severe systemic diseases Not pregnant or lactation

    12. IPD Sharing Statement

    Plan to Share IPD
    No

    Learn more about this trial

    The Causative Insects in Severe Insect Sting Allergy

    We'll reach out to this number within 24 hrs