Combination of Metformin/Inulin vs Inulin on Adiponectin in Metabolic Syndrome
Metabolic Syndrome
About this trial
This is an interventional treatment trial for Metabolic Syndrome focused on measuring Agave inulin, Adiponectin, Metabolic syndrome, Metformin, Insulin resistance
Eligibility Criteria
Inclusion Criteria:
Diagnosis of metabolic syndrome by IDF criteria
- a person to be defined as having the metabolic syndrome they must have: Central obesity (defined as waist circumference* with ethnicity specific values) ≥80 cm in females and ≥90 cm in males; and plus any two of the following four factors:
- Raised triglycerides ≥ 150 mg/dL (1.7 mmol/L) or specific treatment for this lipid abnormality Reduced HDL cholesterol
- < 40 mg/dL (1.03 mmol/L) in males < 50 mg/dL (1.29 mmol/L) in females or specific treatment for this lipid abnormality
- Raised blood pressure systolic BP ≥ 130 or diastolic BP ≥ 85 mm Hg or treatment of previously diagnosed hypertension
- Raised fasting plasma glucose (FPG) ≥ 100 mg/dL (5.6 mmol/L), or previously diagnosed type 2 diabetes
- Age ranging from 40 to 80 years old
- Male patients
- Informed written consent
Exclusion Criteria:
- Kidney disease
- Hepatic disease
- Thyroid disease
- Diabetes mellitus
- Ischemic heart disease
- Drug consumption
- Alcohol consumption of more than 2 ounces daily
- Consumption of drugs that intervene with lipid or glucose metabolism 2 months before
- Blood pressure >160/100 mmHg.
- Lack of adherence to treatment (adherence <80%)
Sites / Locations
- Universidad de Guadalajara
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Active Comparator
Placebo Comparator
Agave inulin + Metformin
Metformin + Placebo of agave inulin
Agave Inulin+Placebo of Metformin
Placebo of Inulin + Placebo of Metformin
5 g of Agave inulin powder every 12 hrs + 500 mg tablet of metformin every 24 hrs
500 mg tablet of metformin every 24 hrs + 5 g every 12 hrs of calcinated magnesia powder
5 g of agave inulin powder every 12 hrs + 500 mg tablet of calcinated magnesia as metformin placebo every 24 hrs
5 g of calcinated magnesia powder every 12 hrs + 500 mg tablet of calcinated magnesia every 24 hrs