Randomized Clinical Trial to Compare the Treatment of Mild Acute Diverticulitis With or Without Antibiotics
Acute Diverticulitis
About this trial
This is an interventional treatment trial for Acute Diverticulitis focused on measuring Acute diverticulitis, Antibiotic, Outpatient treatment
Eligibility Criteria
Inclusion Criteria:
- Patient's written informed consent. Adequate cognitive capacity.
- Adequate family support
- No acute diverticulitis episode in the last 3 months
- mNeff 0 acute diverticulitis (abdominal computed tomography scan)
- No antibiotic treatment in the last 2 weeks
- Immunocompetence*
- No significant comorbidities**
- Good oral tolerance
- Good symptom control
- Maximum one of the following SIRS criteria (* T>38 ºC or <36ºC, L>12,000 or <4000/uL, HR>90 bpm, RR<20 rpm) or CRP>15 mg/dL
Exclusion Criteria:
- Women in pregnancy or breastfeeding
- Age <18 years or > 80 years.
- Absence of the patient's written informed consent. Inadequate cognitive capacity.
- Inadequate family support
- Acute diverticulitis episode in the last 3 months
- Moderate acute diverticulitis (mNeff grade I or upper)
- Antibiotic treatment in the last 2 weeks
- Inflammatory bowel disease
- Immunodepression*
- Presence of significant comorbidities**
- Bad oral tolerance
- Poor symptom control
- More than one of the following SIRS criteria (* T>38 ºC or <36ºC, L>12,000 or <4000/uL, HR>90 bpm, RR<20 rpm) or CRP>15 mg/dL
(*) Immunocompetence is the absence and immunodepression is the presence of any of the following: active neoplastic disease/hematologic malignancy/HIV with low CD4+ count/long-term corticosteroid treatment/immunosuppressant therapy/transplant/splenectomy/genetic immunodeficiency.
(**) We consider significant comorbidities any of the following: poorly controlled diabetes mellitus (HbA1>7mg/dl), cardiologic event in the last 3 months, decompensation of hepatopathy in the last 3 months, renal chronic insufficiency in dialysis programme.
Sites / Locations
- Corporació Sanitària Parc Taulí
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Symptomatic treatment with NSAID
Antibiotic+symptomatic treatment with NSAID
1 g/8 h acetaminophen alternating with 600 mg/8 h ibuprofen
875/125mg /8h amoxicillin/clavulanic acid and symptomatic treatment with 1 g/8 h acetaminophen alternating with 600 mg/8 h ibuprofen