Anesthesia and Postoperative Outcome in Colorectal Cancer Patients
Colorectal Cancer
About this trial
This is an interventional prevention trial for Colorectal Cancer focused on measuring colorectal cancer, TIVA, sevoflurane, lidocaine
Eligibility Criteria
Inclusion Criteria:
- Elective surgery
Exclusion Criteria:
• persistent chronic pain
- chronic medication that may interfere with pain: antiepileptics, NSAID, corticoids
- Contraindications for any of the study medications
- Significant psychiatric disorders (Axa I) (major depression, bipolar disorders, schizophrenia, etc.)
- Significant hepatic (ALAT and/or ASAT > 2 normal values) or renal (plasma creatinine > 2 mg/dl) disorders
- Convulsive disorders requiring medication during the last 2 years
- Planned regional analgesia/anesthesia (spinal or epidural)
- Corticoid dependent asthma
- Autoimmune disorders
- Anti-arrhythmic medication (verapamil, propafenone, amiodarone) that may interfere with lidocaine's anti-arrhythmic effects
- Refusal for study participation
Sites / Locations
- Clinica ATI, str Croitorilor nr 19-21Recruiting
- Institutul Oncologic Prof Dr Ion ChiricutaRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Placebo Comparator
Placebo Comparator
Active Comparator
TIVA + lidocaine
TIVA+placebo
Sevoflurane+placebo
Sevoflurane+lidocaine
TIVA-L. Patients allocated to receive TIVA (propofol-fentanyl) with lidocaine infusion. Interventions: TIVA+lidocaine
TIVA-P. Patients allocated to receive TIVA without lidocaine (placebo). Intervention: TIVA+placebo (saline infusion)
Sevo-P. Patients allocated to receive Sevoflurane anesthesia without lidocaine infusion (placebo). Intervention: sevoflurane anesthesia +placebo (saline infusion)
Sevo-L. Patients allocated to receive sevoflurane anesthesia with lidocaine infusion for the first 48 h postoperatively. Intervention: sevoflurane anesthesia+ lidocaine infusion