Anesthetic Depth Effects Upon Immune Competent Cells (BIS-MA)
Immunotoxicity, Anesthesia, Inert Gas Narcosis
About this trial
This is an interventional treatment trial for Immunotoxicity
Eligibility Criteria
Inclusion Criteria:
- enrolment for longer shoulder surgery
- consent for the standard anesthesia form in combination with the interscalene plexus block
- ASA Status 1-3
Exclusion Criteria:
- sedative premedication
- severe immune deficiency (diabetes, steroid or antihistamine medication, cancer, chemotherapy,
- status post transplantation, drug and alcohol abuse),
- recent surgery (1 month) or blood transfusion
Sites / Locations
- University Medicine of Mannheim, Dept. Anesthesiology and Critical Care Medicine
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Deep Anesthesia
Shallow Anesthesia
Standard anesthesia with fentanyl, propofol for shoulder surgery together with a interscalene plexus block was performed. The anesthesiologist only was informed about the group allocation by the study director and tried to control best for maintenance on target anesthesia level BIS 45 (group 1, deep anesthesia). Anesthesia depth was measured by BIS monitors (BIS Vista, Aspect) for every minute and the minutes below or equal to a BIS level of 45 were counted.
Standard anesthesia with fentanyl, propofol for shoulder surgery together with a inter scalene plexus block was performed. The anesthesiologist only was informed about the group allocation by the study director and tried to control best for maintenance on target anesthesia level BIS ≥ 55 (group 2, shallow anesthesia). Anesthesia depth as measured by BIS monitors (BIS Vista, Aspect) for every minute and the minutes above a BIS level of 45 were counted.