Back to resultsHigh-intensity Interval Training Enhances Mobilization/Functionality of Endothelial Progenitor Cells and Depressed Shedding of Vascular Endothelial Cells Undergoing Hypoxia
Primary Purpose
Hypoxia
Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
HIT
MCT
Sponsored by
About this trial
This is an interventional health services research trial for Hypoxia focused on measuring endothelial progenitor cell, hemodynamic, Exercise, HIIT
Eligibility Criteria
Inclusion Criteria:
- Sedentary life
- Age 20~28
Exclusion Criteria:
- Smokers
- Users of medication/vitamins
- Any cardiopulmonary/hematological risk
- Regular exercise habits at least 1 year
- Exposed to high altitudes (>3000 m) for at least 1 year
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm Type
Experimental
Experimental
No Intervention
Arm Label
High intensity-interval (HIT)
moderate intensity-continuous (MCT)
control (CTL)
Arm Description
Outcomes
Primary Outcome Measures
Circulating progenitor cells conten
by flow cytometry before and after rehabilitation circulating progenitor cells conten before and after hypoxic exercise test
Secondary Outcome Measures
Cardiopulmonary fitness
Full Information
NCT ID
NCT02802462
First Posted
May 19, 2016
Last Updated
June 13, 2016
Sponsor
Chang Gung Memorial Hospital
1. Study Identification
Unique Protocol Identification Number
NCT02802462
Brief Title
High-intensity Interval Training Enhances Mobilization/Functionality of Endothelial Progenitor Cells and Depressed Shedding of Vascular Endothelial Cells Undergoing Hypoxia
Study Type
Interventional
2. Study Status
Record Verification Date
June 2016
Overall Recruitment Status
Completed
Study Start Date
December 2012 (undefined)
Primary Completion Date
December 2013 (Actual)
Study Completion Date
December 2013 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Chang Gung Memorial Hospital
4. Oversight
5. Study Description
Brief Summary
Exercise training improves endothelium-dependent vasodilation, whereas hypoxic stress causes vascular endothelial dysfunction. Monocyte- derived endothelial progenitor cells (Mon-EPCs) contribute to vascular repair process by differentiating into endothelial cells. This study investigates how high-intensity interval (HIT) and moderate intensity-continuous (MCT) exercise training affect circulating Mon-EPC levels and EPC functionality under hypoxic condition. Sixty healthy sedentary males were randomized to engage either HIT (3-minute intervals at 40% and 80%VO2max , n=20) or MCT (sustained 60%VO2max , n=20) for 30 minutes/day, 5 days/week for 6 weeks, or to a control group that did not received exercise intervention (n=20). Mon-EPC characteristics and EPC functionality under hypoxic exercise (HE, 100W under 12%O 2 ) were determined before and after various interventions.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Hypoxia
Keywords
endothelial progenitor cell, hemodynamic, Exercise, HIIT
7. Study Design
Primary Purpose
Health Services Research
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
60 (Actual)
8. Arms, Groups, and Interventions
Arm Title
High intensity-interval (HIT)
Arm Type
Experimental
Arm Title
moderate intensity-continuous (MCT)
Arm Type
Experimental
Arm Title
control (CTL)
Arm Type
No Intervention
Intervention Type
Behavioral
Intervention Name(s)
HIT
Intervention Description
3-minute intervals at 40% and 80%VO 2max
Intervention Type
Behavioral
Intervention Name(s)
MCT
Intervention Description
sustained 60%VO 2max
Primary Outcome Measure Information:
Title
Circulating progenitor cells conten
Description
by flow cytometry before and after rehabilitation circulating progenitor cells conten before and after hypoxic exercise test
Time Frame
6 weeks
Secondary Outcome Measure Information:
Title
Cardiopulmonary fitness
Time Frame
6 weeks
Other Pre-specified Outcome Measures:
Title
Cardiac hemodynamic measurement
Description
evaluate cardiac hemodynamic response to exercise by noninvasive continuous cardiac output monitoring system
Time Frame
6 weeks
Title
Cerebral hemodynamic measurement
Description
Two pairs of near infrared probes were attached to each subject to monitor the absorption of near infrared light across left frontal cortex during graded exercise test
Time Frame
6 weeks
Title
Muscular hemodynamic measurement
Description
Two pairs of near infrared probes were attached to each subject to monitor the absorption of near infrared light across left vastus lateralis muscle during graded exercise test
Time Frame
6 weeks
10. Eligibility
Sex
Male
Minimum Age & Unit of Time
20 Years
Maximum Age & Unit of Time
28 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Sedentary life
Age 20~28
Exclusion Criteria:
Smokers
Users of medication/vitamins
Any cardiopulmonary/hematological risk
Regular exercise habits at least 1 year
Exposed to high altitudes (>3000 m) for at least 1 year
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Jong-Shyan Wang, PhD
Organizational Affiliation
Chang Gung Memorial Hospital
Official's Role
Principal Investigator
12. IPD Sharing Statement
Learn more about this trial
High-intensity Interval Training Enhances Mobilization/Functionality of Endothelial Progenitor Cells and Depressed Shedding of Vascular Endothelial Cells Undergoing Hypoxia
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