Can rTMS Enhance Somatosensory Recovery After Stroke?
Stroke
About this trial
This is an interventional treatment trial for Stroke focused on measuring sensory impairment, sensory deficit, upper limb, transcranial magnetic stimulation, brain stimulation, rehabilitation
Eligibility Criteria
Inclusion Criteria:
- Medically stable at least 6 months after first ever stroke.
- Sufficient endurance to participate in the study.
- Cognition sufficiently intact to give valid informed consent to participate.
- Age > 18years.
- Ability to follow 2 stage commands.
- Impaired but not absent ability to feel touch, vibration and movement of the affected arm.
Exclusion Criteria:
- Acute or progressive cardiac, renal, respiratory, neurological disorders or malignancy.
- Any psychiatric diagnosis or active psychological condition.
- History of substance abuse within the last 6 months
- More than one ischemic stroke or stroke affecting both sides.
- Claustrophobia, or inability to operate the MRI patient call button.
- Pregnancy or pregnancy planning during the study period.
- Lower motor neuron damage or radiculopathy
- Contraindications for rTMS according to the TMS-use guidelines (Rossi et al 2009).
- Inability to understand English.
- Significant neglect for those with left-sided deficits.
Sites / Locations
- Louis Stokes VA Medical Center, Cleveland, OH
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Other
Other
High frequency rTMS
Low frequency rTMS
Sham rTMS
Each subject is provided with three different brain stimulation interventions in a single arm, single session crossover design study. One of the sessions was 5 Hz rTMS
Each subject is provided with three different brain stimulation interventions in a single arm, single session crossover design study. One of the sessions was 1 Hz rTMS
Each subject is provided with three different brain stimulation interventions in a single arm, single session crossover design study. One of the sessions was sham rTMS