Benefit of One Month Zopiclone Intake on Adaptative Servoventilation Compliance (ZODIAC)

This is an interventional supportive care trial for Sleep Apnea, Central Read More

Inclusion Criteria:

• Male or female aged between 18 and 90 years at the initial visit
• Central Sleep Apnea with an AHI ≥ 15/h and at least 50% of central events indicating an ASV therapy, as determined by a ventilatory polygraphy (PG) or a polysomnography (PSG)
• Cardiac Dysfunction with Left Ventricular Ejection fraction(LVEF)> 45% determined by a transthoracic echocardiography (TTE), known for more than 12 weeks and stable for at least 4 weeks;
• Compliance less than 3 hours after 7 days of the setting up of ASV;
• Patient affiliated to a social security scheme or being beneficiary of such scheme;
• Patient voluntarily participating in the research, with written informed consent

Exclusion Criteria:

• Current use of continuous positive airway pressure (cPAP) for treatment of sleep apnea during the last 12 months
• Presence of chronic symptomatic heart failure with reduced left ventricular ejection fraction (LVEF ≤ 45%), and a CSA moderate to severe (AHI ≥15 / h)
• Presence of severe pulmonary bullous disease
• Presence of Pneumothorax or pneumomediastinum
• Hypotension, especially if associated with depletion of intravascular volume
• Dehydration
• Leaking of cerebrospinal fluid, cranial surgery or trauma recently.
• Episode of acute respiratory failure or heart failure in the previous month