Back to results

Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil (Remember)

Primary Purpose

Cognitive Dysfunction, Memory Impairment

Status

Completed

Phase

Phase 3

Locations

United States

Study Type

Interventional

Intervention

Donepezil 5 mg

Placebo

About this trial

This is an interventional treatment trial for Cognitive Dysfunction focused on measuring Donepezil, Cognition, Breast Cancer

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)FemaleDoes not accept healthy volunteers

Inclusion Criteria:

Women ≥18 years old with history of invasive breast cancer
Must have completed at least 4 cycles of adjuvant/neo-adjuvant cytotoxic chemotherapy between 1 and 5 years prior to registration (Ongoing herceptin or other chronic HER 2 directed therapies are allowed).
Patients receiving ongoing hormonal therapy for breast cancer must be on the same hormonal agent for at least 3 months prior to study registration and plan to continue for the duration of the study (9 months)
Use of psychotropic medications (anti-depressants, anxiolytics, sleeping aids, narcotics) is permitted (patient will be asked to list any that have been taken within the last 3 days on the recent medication sheet) if dose is stable over previous 12 weeks. Patients who were previously on one of these psychotropic medications and have subsequently discontinued the drug must have been off the medication for at least 4 weeks prior to enrollment. Patients who have been on a psychotropic medication for at least 12 weeks but have recently switched to a medicine in the same class (for example, switching from one SSRI antidepressant to a different SSRI antidepressant) need to be on a stable dose of the new medication for at least 4 weeks prior to enrollment to be eligible.
Self-reported cognitive problem plus a measured memory deficit (score <7 on single trial of Eligibility Pre-screen HVLT-R Form 3).
ECOG performance status 0-2
Ability to understand and the willingness to sign a written informed consent document.
Must be able to speak English.
Patients currently taking a moderate risk QTc prolongation medication (see Appendix A) are allowed if one of the following criteria are met: 1) The moderate risk QTc prolongation medication is stopped. The patient should be off the moderate risk QTc prolongation medication for at least 5 half-lives before starting study drug. 2) Patients that continue using a moderate risk QTc prolongation medication must have a normal QTc interval (≤ 460 milliseconds) on a screening ECG following informed consent and prior to study enrollment. These patients will also be monitored at designated study follow-up visits per Section 7.5 (monitored 3-7 days after initiating study drug, at week 3, and 3-7 days after the study drug dose increase with ECG's to assess the QTc interval; the QTc level must be ≤ 500 milliseconds at these time points in order to continue on the study drug). 3) Moderate risk QTc prolongation medications that are only taken occasionally may be stopped at the discretion of the treating site physician. Patients must be off medication for at least 5 half-lives prior to starting study drug to be eligible.
Patients currently taking a moderate risk bradycardia-causing agent (see Appendix B) are allowed if one of the following criteria are met: 1) The moderate risk bradycardia-causing agent is stopped. The patient should be off the moderate risk bradycardia-causing agent for at least 5 half-lives before starting study drug. 2) Patients that continue using a moderate risk bradycardia-causing agent must have a resting heart rate ≥ 55 beats per minute at screening following informed consent. These patients' resting heart rate will be monitored 3-7 days after initiating study drug, at week 3, and 3-7 days after the study drug dose increase per Section 7.5. 3) Moderate risk bradycardia-causing agents that are only taken occasionally may be stopped at the discretion of the treating site physician. Patients must be off medication for at least 5 half-lives prior to starting study drug to be eligible.

Exclusion Criteria:

Evidence or suspected recurrent or metastatic disease.
Prior brain irradiation is not allowed.
Planned therapy (surgery, radiation, chemotherapy, or immunotherapy) while on the study for brain and/or extracranial primary/metastatic disease.
Hypersensitivity to donepezil or piperidine derivatives
Current use of ceritinib
Current use of Succinylcholine/Acetylcholinesterase Inhibitors(as listed in Appendix C). For patients who have used these medications, they must not have used them within 4 weeks prior to enrollment.
Current use of high-risk QTc prolonging medication(s). See Appendix D
Current use of quinidine or systemic ketoconazole (topical ketoconazole is acceptable to use while on study).
History of dementia, Alzheimer's disease, multi-infarct dementia or clinically significant Cerebrovascular Accident (history of transient ischemic attack (TIA) is allowed).
Current use of donepezil, galantamine, rivastigmine, tacrine, memantine, methylphenidate, dextroamphetamine, or any other specific cognition enhancing drug(s). For patients who have used these medications, they must not have used them within 4 weeks prior to pre-screening. Patients who plan to start taking a cognition enhancing drug while on this study are also excluded.
History of allergic reactions attributed to compounds of similar chemical or biologic composition to donepezil. Hypersensitivity to donepezil.
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, recent myocardial infarction, cardiac arrhythmia.
Major medical conditions that affect cognition, traumatic brain injury, multiple sclerosis, acute severe fatigue, chronic fatigue syndrome or fibromyalgia.
Psychiatric illness/social situations that would limit compliance with study requirements including but not limited to a history of schizophrenia, psychosis or substance abuse.
Untreated current severe depression. Currently treated depression is permitted if treatment is stable.
Patients with a resting heart rate less than 55 beats per minute, seizure disorder or peptic ulcer disease (PUD).
History of congenital long QT syndrome or torsades de pointes.
Screening QTc of > 460 milliseconds will make the patient ineligible.
Pregnant women are excluded from this study. Following informed consent, women of child-bearing potential will be screened with a serum or urine pregnancy test within 10 days of enrollment. The effects of donepezil on the developing human fetus at the recommended therapeutic dose are unknown. For this reason and because donepezil is known to be teratogenic, women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her study physician immediately.
It is unknown whether donepezil is excreted in breast milk, for this reason women who are currently breast-feeding are not eligible for this study.
On another intervention study involving medication at the time of enrollment or during participation in this study. (Exception: Patients will remain eligible for this study if they are also enrolled on the Alliance for Clinical Trials in Oncology study (NCT02927249): Aspirin in Preventing Recurrence of Cancer in Patients with HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy. Studies that involve only blood draws or questionnaires are also permitted.)
Use of investigational drugs likely to affect cognition within 30 days prior to pre-screening visit.

Arms of the Study

Arm 1

Arm 2

Arm Type

Active Comparator

Placebo Comparator

Arm Label

Donepezil

Placebo

Arm Description

Participants will be asked to take one 5 mg tablet of donepezil daily for 6 weeks followed by two 5 mg tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.

Participants will be asked to take one tablet of matching placebo daily for 6 weeks followed by two tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.

Outcomes

Primary Outcome Measures

Hopkins Verbal Learning Test-Revised (HVLT-R) - Total

Hopkins Verbal Learning Test-Revised (HVLT-R): The HVLT-R measures verbal learning and memory. It consists of a 12-item word list which is read to patients on three successive learning trials. Free recall scores are recorded for each learning trial. After a 20-minute interval during which patients complete other non-interfering tasks and questionnaires they are asked to recall the target words. Range is 0-36 with higher values representing better verbal learning and memory.

Secondary Outcome Measures

Digit Symbol Coding Results

The digit symbol coding (DSC) test measures processing speed, working memory, visuospatial processing, and attention. The DSC test measures processing speed. It requires respondents to transcribe symbols (e.g., >) associated with a number (0-9) into empty boxes beneath a series of randomly ordered numbers. Total score is number of correctly transcribed symbols in 2 minutes. Scores range from 0 to 100, with higher scores indicating higher cognitive function.

PROMIS 7-item Fatigue Scale Converted to T-scale Results

This self-report scale assesses fatigue. Scale ranges from 7 to 35 converted to T-scale ranging 29.4 to 83.2 Higher scores representing more fatigue.

FACT-Cognition (Version 3): Perceived Cognitive Impairment

The FACT-Cog is a patient-reported outcome (PRO) that includes subscales to measure Perceived Cognitive Impairment (PCI, n = 20 items, score range 0-80). Higher FACT-Cog PCI scores are better and indicate less cognitive impairment.

Controlled Oral Word Association Test (COWA) Results

The Controlled Oral Word Association Test from the Halstead-Reitan Neuropsychological Battery is a verbal fluency test in which participants are asked to say as many words as possible from a given category and in a specified timeframe (typically 60 seconds). Scores are the sum of all acceptable words. Minimum is 0 with no specified maximum; higher values represent better verbal fluency.

Trail Making Test, Parts A & B (TMT-A, TMT-B) Results

TMT Part A consists of 25 circles on a piece of paper with the numbers 1 to 25 written randomly in each. For Part A, the person is tasked with drawing a line from one circle to the next in ascending numerical order, from 1 to 25, as quickly as possible. The lines between the circles are referred to as the "trail." Range 1-300 in seconds. Lower values indicate completing task faster with less difficulty. It is a measure of executive functioning with lower values being better. TMT Part B also consists of 25 circles on a piece of paper, But, rather than all of the circles containing numbers, they contain numbers (1 to 12) and letters (A through L). For Part B, the person is tasked with connecting the circles in ascending order, alternating back and forth from numbers to letters. In other words, the "trail" would be connected like this:1-A-2-B-3-C-4-D-5-E-6-F-7-G-8-H-9-I-10-J-11-K-12-L-13. The range 1-300 seconds. Higher values indicate worse executive functioning.

Digit Span Test-Backwards (DST-B)

The Digit Span Task (Backwards-Only Version) measures working memory. On each question the participant repeats the numbers in reverse order of that presented aloud by the examiner (e.g., If the examiner says "5-6", the correct response would be "6-5"; If the examiner says "5-1-7-4-2-3-8", the correct response would be "8-3-2-4-7-1-5"). Score is 0 to 16 with higher scores representing better working memory.

Full Information

NCT ID

NCT02822573

First Posted

June 30, 2016

Last Updated

August 17, 2023

Sponsor

Wake Forest University Health Sciences

Collaborators

National Cancer Institute (NCI)

1. Study Identification

Unique Protocol Identification Number

NCT02822573

Brief Title

Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil

Acronym

Remember

Official Title

A Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil in Chemotherapy Exposed Breast Cancer Survivors With Cognitive Impairment

Study Type

Interventional

2. Study Status

Record Verification Date

July 2023

Overall Recruitment Status

Completed

Study Start Date

May 30, 2017 (Actual)

Primary Completion Date

July 29, 2022 (Actual)

Study Completion Date

July 29, 2022 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Wake Forest University Health Sciences

Collaborators

National Cancer Institute (NCI)

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

This study is to compare the safety and effects of donepezil (Aricept) for patients reporting cognitive or memory issues after receiving chemotherapy for breast cancer. Patients will receive either donepezil or placebo for 24 weeks. The primary objective is to see if memory improves with the use of donepezil during the study.

Detailed Description

Randomized, double-blind, placebo-controlled study with 24 weeks of exposure to drug or placebo followed by a 12 week wash-out period. Patients who meet the eligibility criteria will be stratified by age (<50, 50-59, 60-69, ≥70) and randomized to donepezil or placebo with equal probability. A total of 276 patients will be enrolled (138 per arm). We expect an accrual rate of 7-10 participants per month based on our prior feasibility study. We expect the study to be complete within 40 months. Participants will be asked to take one 5mg tablet of donepezil or one tablet of matching placebo orally once a day for 6 weeks followed by two 5mg tablets (10mg total) of donepezil or two placebo tablets orally once a day for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period. Time points for performing study assessments. Participants will be administered the cognitive battery of tests and questionnaires at baseline, week 12, week 24 and week 36. In addition, a single vial of blood will be drawn at baseline for apolipoprotein E (APOE) genotyping and subsequent bioassays (pending supplemental funding).

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Cognitive Dysfunction, Memory Impairment

Keywords

Donepezil, Cognition, Breast Cancer

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigatorOutcomes Assessor

Allocation

Randomized

Enrollment

276 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Donepezil

Arm Type

Active Comparator

Arm Description

Participants will be asked to take one 5 mg tablet of donepezil daily for 6 weeks followed by two 5 mg tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.

Arm Title

Placebo

Arm Type

Placebo Comparator

Arm Description

Participants will be asked to take one tablet of matching placebo daily for 6 weeks followed by two tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.

Intervention Type

Drug

Intervention Name(s)

Donepezil 5 mg

Other Intervention Name(s)

Aricept

Intervention Description

Participants will be asked to take one 5 mg tablet of donepezil daily for 6 weeks followed by two 5mg tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.

Intervention Type

Drug

Intervention Name(s)

Placebo

Other Intervention Name(s)

Sugar Pill

Intervention Description

Participants will be asked to take one tablet of matching placebo daily for 6 weeks followed by two tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.

Primary Outcome Measure Information:

Title

Hopkins Verbal Learning Test-Revised (HVLT-R) - Total

Description

Time Frame

Baseline, Weeks 12, 24, 36

Secondary Outcome Measure Information:

Title

Digit Symbol Coding Results

Description

Time Frame

Baseline, Weeks 12, 24, 36

Title

PROMIS 7-item Fatigue Scale Converted to T-scale Results

Description

This self-report scale assesses fatigue. Scale ranges from 7 to 35 converted to T-scale ranging 29.4 to 83.2 Higher scores representing more fatigue.

Time Frame

Baseline, Weeks 12, 24, 36

Title

FACT-Cognition (Version 3): Perceived Cognitive Impairment

Description

Time Frame

Baseline, Weeks 12, 24, 36

Title

Controlled Oral Word Association Test (COWA) Results

Description

Time Frame

Baseline, Weeks 12, 24, 36

Title

Trail Making Test, Parts A & B (TMT-A, TMT-B) Results

Description

Time Frame

Baseline, Weeks 12, 24, 36

Title

Digit Span Test-Backwards (DST-B)

Description

Time Frame

Baseline, Weeks 12, 24, 36

10. Eligibility

Sex

Female

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

75 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Women ≥18 years old with history of invasive breast cancer Must have completed at least 4 cycles of adjuvant/neo-adjuvant cytotoxic chemotherapy between 1 and 5 years prior to registration (Ongoing herceptin or other chronic human epidermal growth factor receptor 2 (HER2) directed therapies are allowed). Patients receiving ongoing hormonal therapy for breast cancer must be on the same hormonal agent for at least 3 months prior to study registration and plan to continue for the duration of the study (9 months) Use of psychotropic medications (anti-depressants, anxiolytics, sleeping aids, narcotics) is permitted (patient will be asked to list any that have been taken within the last 3 days on the recent medication sheet) if dose is stable over previous 12 weeks. Patients who were previously on one of these psychotropic medications and have subsequently discontinued the drug must have been off the medication for at least 4 weeks prior to enrollment. Patients who have been on a psychotropic medication for at least 12 weeks but have recently switched to a medicine in the same class (for example, switching from one selective serotonin reuptake inhibitor (SSRI) antidepressant to a different SSRI antidepressant) need to be on a stable dose of the new medication for at least 4 weeks prior to enrollment to be eligible. Self-reported cognitive problem plus a measured memory deficit (score <7 on single trial of Eligibility Pre-screen Hopkins Verbal Learning Test - Revised (HVLT-R) Form 3). Eastern Cooperative Oncology Group (ECOG) performance status 0-2 Ability to understand and the willingness to sign a written informed consent document. Must be able to speak English. Patients currently taking a moderate risk corrected QT interval (QTc) prolongation medication (see Appendix A) are allowed if one of the following criteria are met: 1) The moderate risk QTc prolongation medication is stopped. The patient should be off the moderate risk QTc prolongation medication for at least 5 half-lives before starting study drug. 2) Patients that continue using a moderate risk QTc prolongation medication must have a normal QTc interval (≤ 460 milliseconds) on a screening ECG following informed consent and prior to study enrollment. These patients will also be monitored at designated study follow-up visits per Section 7.5 (monitored 3-7 days after initiating study drug, at week 3, and 3-7 days after the study drug dose increase with ECG's to assess the QTc interval; the QTc level must be ≤ 500 milliseconds at these time points in order to continue on the study drug). 3) Moderate risk QTc prolongation medications that are only taken occasionally may be stopped at the discretion of the treating site physician. Patients must be off medication for at least 5 half-lives prior to starting study drug to be eligible. Patients currently taking a moderate risk bradycardia-causing agent (see Appendix B) are allowed if one of the following criteria are met: 1) The moderate risk bradycardia-causing agent is stopped. The patient should be off the moderate risk bradycardia-causing agent for at least 5 half-lives before starting study drug. 2) Patients that continue using a moderate risk bradycardia-causing agent must have a resting heart rate ≥ 55 beats per minute at screening following informed consent. These patients' resting heart rate will be monitored 3-7 days after initiating study drug, at week 3, and 3-7 days after the study drug dose increase per Section 7.5. 3) Moderate risk bradycardia-causing agents that are only taken occasionally may be stopped at the discretion of the treating site physician. Patients must be off medication for at least 5 half-lives prior to starting study drug to be eligible. Exclusion Criteria: Evidence or suspected recurrent or metastatic disease. Prior brain irradiation is not allowed. Planned therapy (surgery, radiation, chemotherapy, or immunotherapy) while on the study for brain and/or extracranial primary/metastatic disease. Hypersensitivity to donepezil or piperidine derivatives Current use of ceritinib Current use of Succinylcholine/Acetylcholinesterase Inhibitors(as listed in Appendix C). For patients who have used these medications, they must not have used them within 4 weeks prior to enrollment. Current use of high-risk QTc prolonging medication(s). See Appendix D Current use of quinidine or systemic ketoconazole (topical ketoconazole is acceptable to use while on study). History of dementia, Alzheimer's disease, multi-infarct dementia or clinically significant Cerebrovascular Accident (history of transient ischemic attack (TIA) is allowed). Current use of donepezil, galantamine, rivastigmine, tacrine, memantine, methylphenidate, dextroamphetamine, or any other specific cognition enhancing drug(s). For patients who have used these medications, they must not have used them within 4 weeks prior to pre-screening. Patients who plan to start taking a cognition enhancing drug while on this study are also excluded. History of allergic reactions attributed to compounds of similar chemical or biologic composition to donepezil. Hypersensitivity to donepezil. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, recent myocardial infarction, cardiac arrhythmia. Major medical conditions that affect cognition, traumatic brain injury, multiple sclerosis, acute severe fatigue, chronic fatigue syndrome or fibromyalgia. Psychiatric illness/social situations that would limit compliance with study requirements including but not limited to a history of schizophrenia, psychosis or substance abuse. Untreated current severe depression. Currently treated depression is permitted if treatment is stable. Patients with a resting heart rate less than 55 beats per minute, seizure disorder or peptic ulcer disease (PUD). History of congenital long QT syndrome or torsades de pointes. Screening QTc of > 460 milliseconds will make the patient ineligible. Pregnant women are excluded from this study. Following informed consent, women of child-bearing potential will be screened with a serum or urine pregnancy test within 10 days of enrollment. The effects of donepezil on the developing human fetus at the recommended therapeutic dose are unknown. For this reason and because donepezil is known to be teratogenic, women of child-bearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her study physician immediately. It is unknown whether donepezil is excreted in breast milk, for this reason women who are currently breast-feeding are not eligible for this study. On another intervention study involving medication at the time of enrollment or during participation in this study. (Exception: Patients will remain eligible for this study if they are also enrolled on the Alliance for Clinical Trials in Oncology study (NCT02927249): Aspirin in Preventing Recurrence of Cancer in Patients with HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy. Studies that involve only blood draws or questionnaires are also permitted.) Use of investigational drugs likely to affect cognition within 30 days prior to pre-screening visit.

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Stephen R Rapp, PhD

Organizational Affiliation

Wake Forest University Health Sciences

Official's Role

Principal Investigator

Facility Information:

Facility Name

Kaiser Permanente-Anaheim

City

Anaheim

State/Province

California

ZIP/Postal Code

92806

Country

United States

Facility Name

Kaiser Permanente-Deer Valley Medical Center

City

Antioch

State/Province

California

ZIP/Postal Code

94531

Country

United States

Facility Name

Kaiser Permanente-Baldwin Park

City

Baldwin Park

State/Province

California

ZIP/Postal Code

91706

Country

United States

Facility Name

Kaiser Permanente-Bellflower

City

Bellflower

State/Province

California

ZIP/Postal Code

90706

Country

United States

Facility Name

Kaiser Permanente-Fontana

City

Fontana

State/Province

California

ZIP/Postal Code

92335

Country

United States

Facility Name

Kaiser Permanente-Fremont

City

Fremont

State/Province

California

ZIP/Postal Code

94538

Country

United States

Facility Name

Fresno Cancer Center

City

Fresno

State/Province

California

ZIP/Postal Code

93720

Country

United States

Facility Name

Kaiser Permanente-Fresno

City

Fresno

State/Province

California

ZIP/Postal Code

93720

Country

United States

Facility Name

Kaiser Permanente - Harbor City

City

Harbor City

State/Province

California

ZIP/Postal Code

90710

Country

United States

Facility Name

Kaiser Permanente-Irvine

City

Irvine

State/Province

California

ZIP/Postal Code

92618

Country

United States

Facility Name

Kaiser Permanente Los Angeles Medical Center

City

Los Angeles

State/Province

California

ZIP/Postal Code

90027

Country

United States

Facility Name

Kaiser Permanente West Los Angeles

City

Los Angeles

State/Province

California

ZIP/Postal Code

90034

Country

United States

Facility Name

Kaiser Permanente-Modesto

City

Modesto

State/Province

California

ZIP/Postal Code

95356

Country

United States

Facility Name

Kaiser Permanente-Oakland

City

Oakland

State/Province

California

ZIP/Postal Code

94611

Country

United States

Facility Name

Kaiser Permanente-Ontario

City

Ontario

State/Province

California

ZIP/Postal Code

91761

Country

United States

Facility Name

Kaiser Permanente - Panorama City

City

Panorama City

State/Province

California

ZIP/Postal Code

91402

Country

United States

Facility Name

Kaiser Permanente-Rancho Cordova Cancer Center

City

Rancho Cordova

State/Province

California

ZIP/Postal Code

95670

Country

United States

Facility Name

Kaiser Permanente-Richmond

City

Richmond

State/Province

California

ZIP/Postal Code

94801

Country

United States

Facility Name

Kaiser Permanente-Riverside

City

Riverside

State/Province

California

ZIP/Postal Code

92505

Country

United States

Facility Name

Kaiser Permanente-Roseville

City

Roseville

State/Province

California

ZIP/Postal Code

95661

Country

United States

Facility Name

The Permanente Medical Group-Roseville Radiation Oncology

City

Roseville

State/Province

California

ZIP/Postal Code

95678

Country

United States

Facility Name

Kaiser Permanente Downtown Commons

City

Sacramento

State/Province

California

ZIP/Postal Code

95814

Country

United States

Facility Name

Kaiser Permanente-South Sacramento

City

Sacramento

State/Province

California

ZIP/Postal Code

95823

Country

United States

Facility Name

South Sacramento Cancer Center

City

Sacramento

State/Province

California

ZIP/Postal Code

95823

Country

United States

Facility Name

Kaiser Permanente - Sacramento

City

Sacramento

State/Province

California

ZIP/Postal Code

95825

Country

United States

Facility Name

Kaiser Permanente-San Diego Zion

City

San Diego

State/Province

California

ZIP/Postal Code

92120

Country

United States

Facility Name

Kaiser Permanente-San Francisco

City

San Francisco

State/Province

California

ZIP/Postal Code

94115

Country

United States

Facility Name

Kaiser Permanente-Santa Teresa-San Jose

City

San Jose

State/Province

California

ZIP/Postal Code

95119

Country

United States

Facility Name

Kaiser Permanente San Leandro

City

San Leandro

State/Province

California

ZIP/Postal Code

94577

Country

United States

Facility Name

Kaiser Permanente-San Marcos

City

San Marcos

State/Province

California

ZIP/Postal Code

92078

Country

United States

Facility Name

Kaiser Permanente-San Rafael

City

San Rafael

State/Province

California

ZIP/Postal Code

94903

Country

United States

Facility Name

Kaiser San Rafael-Gallinas

City

San Rafael

State/Province

California

ZIP/Postal Code

94903

Country

United States

Facility Name

Kaiser Permanente Medical Center - Santa Clara

City

Santa Clara

State/Province

California

ZIP/Postal Code

95051

Country

United States

Facility Name

Kaiser Permanente-Santa Rosa

City

Santa Rosa

State/Province

California

ZIP/Postal Code

95403

Country

United States

Facility Name

Kaiser Permanente-South San Francisco

City

South San Francisco

State/Province

California

ZIP/Postal Code

94080

Country

United States

Facility Name

Kaiser Permanente-Stockton

City

Stockton

State/Province

California

ZIP/Postal Code

95210

Country

United States

Facility Name

Kaiser Permanente Medical Center-Vacaville

City

Vacaville

State/Province

California

ZIP/Postal Code

95688

Country

United States

Facility Name

Kaiser Permanente-Vallejo

City

Vallejo

State/Province

California

ZIP/Postal Code

94589

Country

United States

Facility Name

Kaiser Permanente-Walnut Creek

City

Walnut Creek

State/Province

California

ZIP/Postal Code

94596

Country

United States

Facility Name

Kaiser Permanente-Woodland Hills

City

Woodland Hills

State/Province

California

ZIP/Postal Code

91367

Country

United States

Facility Name

Penrose-Saint Francis Healthcare

City

Colorado Springs

State/Province

Colorado

ZIP/Postal Code

80907

Country

United States

Facility Name

Rocky Mountain Cancer Centers-Penrose

City

Colorado Springs

State/Province

Colorado

ZIP/Postal Code

80907

Country

United States

Facility Name

Kaiser Permanente-Franklin

City

Denver

State/Province

Colorado

ZIP/Postal Code

80205

Country

United States

Facility Name

Porter Adventist Hospital

City

Denver

State/Province

Colorado

ZIP/Postal Code

80210

Country

United States

Facility Name

Kaiser Permanente-Rock Creek

City

Lafayette

State/Province

Colorado

ZIP/Postal Code

80026

Country

United States

Facility Name

Littleton Adventist Hospital

City

Littleton

State/Province

Colorado

ZIP/Postal Code

80122

Country

United States

Facility Name

Kaiser Permanente-Lone Tree

City

Lone Tree

State/Province

Colorado

ZIP/Postal Code

80124

Country

United States

Facility Name

Longmont United Hospital

City

Longmont

State/Province

Colorado

ZIP/Postal Code

80501

Country

United States

Facility Name

Parker Adventist Hospital

City

Parker

State/Province

Colorado

ZIP/Postal Code

80138

Country

United States

Facility Name

Helen F Graham Cancer Center

City

Newark

State/Province

Delaware

ZIP/Postal Code

19713

Country

United States

Facility Name

Medical Oncology Hematology Consultants PA

City

Newark

State/Province

Delaware

ZIP/Postal Code

19713

Country

United States

Facility Name

Christiana Care Health System-Christiana Hospital

City

Newark

State/Province

Delaware

ZIP/Postal Code

19718

Country

United States

Facility Name

Beebe Health Campus

City

Rehoboth Beach

State/Province

Delaware

ZIP/Postal Code

19971

Country

United States

Facility Name

TidalHealth Nanticoke / Allen Cancer Center

City

Seaford

State/Province

Delaware

ZIP/Postal Code

19973

Country

United States

Facility Name

Holy Cross Hospital

City

Fort Lauderdale

State/Province

Florida

ZIP/Postal Code

33308

Country

United States

Facility Name

Pali Momi Medical Center

City

'Aiea

State/Province

Hawaii

ZIP/Postal Code

96701

Country

United States

Facility Name

Hawaii Cancer Care Inc - Waterfront Plaza

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Queen's Cancer Cenrer - POB I

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Queen's Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Straub Clinic and Hospital

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

University of Hawaii Cancer Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96813

Country

United States

Facility Name

Hawaii Cancer Care Inc-Liliha

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

Queen's Cancer Center - Kuakini

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96817

Country

United States

Facility Name

Kaiser Permanente Moanalua Medical Center

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96819

Country

United States

Facility Name

Kapiolani Medical Center for Women and Children

City

Honolulu

State/Province

Hawaii

ZIP/Postal Code

96826

Country

United States

Facility Name

Saint Luke's Cancer Institute - Boise

City

Boise

State/Province

Idaho

ZIP/Postal Code

83712

Country

United States

Facility Name

Saint Luke's Cancer Institute - Fruitland

City

Fruitland

State/Province

Idaho

ZIP/Postal Code

83619

Country

United States

Facility Name

Saint Luke's Cancer Institute - Meridian

City

Meridian

State/Province

Idaho

ZIP/Postal Code

83642

Country

United States

Facility Name

Saint Luke's Cancer Institute - Nampa

City

Nampa

State/Province

Idaho

ZIP/Postal Code

83686

Country

United States

Facility Name

Saint Luke's Cancer Institute - Twin Falls

City

Twin Falls

State/Province

Idaho

ZIP/Postal Code

83301

Country

United States

Facility Name

Illinois CancerCare-Bloomington

City

Bloomington

State/Province

Illinois

ZIP/Postal Code

61704

Country

United States

Facility Name

Illinois CancerCare-Canton

City

Canton

State/Province

Illinois

ZIP/Postal Code

61520

Country

United States

Facility Name

Centralia Oncology Clinic

City

Centralia

State/Province

Illinois

ZIP/Postal Code

62801

Country

United States

Facility Name

Carle on Vermilion

City

Danville

State/Province

Illinois

ZIP/Postal Code

61832

Country

United States

Facility Name

Cancer Care Specialists of Illinois - Decatur

City

Decatur

State/Province

Illinois

ZIP/Postal Code

62526

Country

United States

Facility Name

Decatur Memorial Hospital

City

Decatur

State/Province

Illinois

ZIP/Postal Code

62526

Country

United States

Facility Name

Carle Physician Group-Effingham

City

Effingham

State/Province

Illinois

ZIP/Postal Code

62401

Country

United States

Facility Name

Crossroads Cancer Center

City

Effingham

State/Province

Illinois

ZIP/Postal Code

62401

Country

United States

Facility Name

Illinois CancerCare-Galesburg

City

Galesburg

State/Province

Illinois

ZIP/Postal Code

61401

Country

United States

Facility Name

Illinois CancerCare-Kewanee Clinic

City

Kewanee

State/Province

Illinois

ZIP/Postal Code

61443

Country

United States

Facility Name

Carle Physician Group-Mattoon/Charleston

City

Mattoon

State/Province

Illinois

ZIP/Postal Code

61938

Country

United States

Facility Name

Illinois CancerCare-Ottawa Clinic

City

Ottawa

State/Province

Illinois

ZIP/Postal Code

61350

Country

United States

Facility Name

Illinois CancerCare-Pekin

City

Pekin

State/Province

Illinois

ZIP/Postal Code

61554

Country

United States

Facility Name

Illinois CancerCare-Peoria

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61615

Country

United States

Facility Name

Illinois CancerCare-Peru

City

Peru

State/Province

Illinois

ZIP/Postal Code

61354

Country

United States

Facility Name

Carle Cancer Center

City

Urbana

State/Province

Illinois

ZIP/Postal Code

61801

Country

United States

Facility Name

The Carle Foundation Hospital

City

Urbana

State/Province

Illinois

ZIP/Postal Code

61801

Country

United States

Facility Name

Physicians' Clinic of Iowa PC

City

Cedar Rapids

State/Province

Iowa

ZIP/Postal Code

52402

Country

United States

Facility Name

Iowa Methodist Medical Center

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50309

Country

United States

Facility Name

Medical Oncology and Hematology Associates-Des Moines

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50309

Country

United States

Facility Name

Broadlawns Medical Center

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50314

Country

United States

Facility Name

Mercy Medical Center - Des Moines

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50314

Country

United States

Facility Name

Iowa Lutheran Hospital

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50316

Country

United States

Facility Name

Methodist West Hospital

City

West Des Moines

State/Province

Iowa

ZIP/Postal Code

50266-7700

Country

United States

Facility Name

Cancer Center of Kansas - Chanute

City

Chanute

State/Province

Kansas

ZIP/Postal Code

66720

Country

United States

Facility Name

Cancer Center of Kansas - El Dorado

City

El Dorado

State/Province

Kansas

ZIP/Postal Code

67042

Country

United States

Facility Name

Cancer Center of Kansas - Fort Scott

City

Fort Scott

State/Province

Kansas

ZIP/Postal Code

66701

Country

United States

Facility Name

Cancer Center of Kansas-Independence

City

Independence

State/Province

Kansas

ZIP/Postal Code

67301

Country

United States

Facility Name

Cancer Center of Kansas-Kingman

City

Kingman

State/Province

Kansas

ZIP/Postal Code

67068

Country

United States

Facility Name

Cancer Center of Kansas-Manhattan

City

Manhattan

State/Province

Kansas

ZIP/Postal Code

66502

Country

United States

Facility Name

Cancer Center of Kansas - McPherson

City

McPherson

State/Province

Kansas

ZIP/Postal Code

67460

Country

United States

Facility Name

Cancer Center of Kansas - Newton

City

Newton

State/Province

Kansas

ZIP/Postal Code

67114

Country

United States

Facility Name

Cancer Center of Kansas - Parsons

City

Parsons

State/Province

Kansas

ZIP/Postal Code

67357

Country

United States

Facility Name

Cancer Center of Kansas - Salina

City

Salina

State/Province

Kansas

ZIP/Postal Code

67401

Country

United States

Facility Name

Cancer Center of Kansas - Wellington

City

Wellington

State/Province

Kansas

ZIP/Postal Code

67152

Country

United States

Facility Name

Associates In Womens Health

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67208

Country

United States

Facility Name

Cancer Center of Kansas-Wichita Medical Arts Tower

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67208

Country

United States

Facility Name

Ascension Via Christi Hospitals Wichita

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Cancer Center of Kansas - Wichita

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Cancer Center of Kansas - Winfield

City

Winfield

State/Province

Kansas

ZIP/Postal Code

67156

Country

United States

Facility Name

Flaget Memorial Hospital

City

Bardstown

State/Province

Kentucky

ZIP/Postal Code

40004

Country

United States

Facility Name

Saint Joseph Radiation Oncology Resource Center

City

Lexington

State/Province

Kentucky

ZIP/Postal Code

40504

Country

United States

Facility Name

Saint Joseph Hospital East

City

Lexington

State/Province

Kentucky

ZIP/Postal Code

40509

Country

United States

Facility Name

Saint Joseph London

City

London

State/Province

Kentucky

ZIP/Postal Code

40741

Country

United States

Facility Name

Christus Saint Frances Cabrini Hospital

City

Alexandria

State/Province

Louisiana

ZIP/Postal Code

71301

Country

United States

Facility Name

LSU Health Baton Rouge-North Clinic

City

Baton Rouge

State/Province

Louisiana

ZIP/Postal Code

70805

Country

United States

Facility Name

Louisiana Hematology Oncology Associates LLC

City

Baton Rouge

State/Province

Louisiana

ZIP/Postal Code

70809

Country

United States

Facility Name

Mary Bird Perkins Cancer Center

City

Baton Rouge

State/Province

Louisiana

ZIP/Postal Code

70809

Country

United States

Facility Name

Our Lady of the Lake Physicians Group - Medical Oncology

City

Baton Rouge

State/Province

Louisiana

ZIP/Postal Code

70809

Country

United States

Facility Name

Louisiana State University Health Science Center

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70112

Country

United States

Facility Name

University Medical Center New Orleans

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70112

Country

United States

Facility Name

Ochsner Medical Center Jefferson

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70121

Country

United States

Facility Name

CHRISTUS Highland Medical Center

City

Shreveport

State/Province

Louisiana

ZIP/Postal Code

71105

Country

United States

Facility Name

Saint Joseph Mercy Hospital

City

Ann Arbor

State/Province

Michigan

ZIP/Postal Code

48106

Country

United States

Facility Name

IHA Hematology Oncology Consultants-Brighton

City

Brighton

State/Province

Michigan

ZIP/Postal Code

48114

Country

United States

Facility Name

Saint Joseph Mercy Brighton

City

Brighton

State/Province

Michigan

ZIP/Postal Code

48114

Country

United States

Facility Name

IHA Hematology Oncology Consultants-Canton

City

Canton

State/Province

Michigan

ZIP/Postal Code

48188

Country

United States

Facility Name

Saint Joseph Mercy Canton

City

Canton

State/Province

Michigan

ZIP/Postal Code

48188

Country

United States

Facility Name

Caro Cancer Center

City

Caro

State/Province

Michigan

ZIP/Postal Code

48723

Country

United States

Facility Name

IHA Hematology Oncology Consultants-Chelsea

City

Chelsea

State/Province

Michigan

ZIP/Postal Code

48118

Country

United States

Facility Name

Saint Joseph Mercy Chelsea

City

Chelsea

State/Province

Michigan

ZIP/Postal Code

48118

Country

United States

Facility Name

Hematology Oncology Consultants-Clarkston

City

Clarkston

State/Province

Michigan

ZIP/Postal Code

48346

Country

United States

Facility Name

Newland Medical Associates-Clarkston

City

Clarkston

State/Province

Michigan

ZIP/Postal Code

48346

Country

United States

Facility Name

Beaumont Hospital - Dearborn

City

Dearborn

State/Province

Michigan

ZIP/Postal Code

48124

Country

United States

Facility Name

Green Bay Oncology - Escanaba

City

Escanaba

State/Province

Michigan

ZIP/Postal Code

49829

Country

United States

Facility Name

Beaumont Hospital - Farmington Hills

City

Farmington Hills

State/Province

Michigan

ZIP/Postal Code

48336

Country

United States

Facility Name

Genesee Cancer and Blood Disease Treatment Center

City

Flint

State/Province

Michigan

ZIP/Postal Code

48503

Country

United States

Facility Name

Genesee Hematology Oncology PC

City

Flint

State/Province

Michigan

ZIP/Postal Code

48503

Country

United States

Facility Name

Genesys Hurley Cancer Institute

City

Flint

State/Province

Michigan

ZIP/Postal Code

48503

Country

United States

Facility Name

Hurley Medical Center

City

Flint

State/Province

Michigan

ZIP/Postal Code

48503

Country

United States

Facility Name

Mercy Health Saint Mary's

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

Spectrum Health at Butterworth Campus

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

William Beaumont Hospital-Grosse Pointe

City

Grosse Pointe

State/Province

Michigan

ZIP/Postal Code

48230

Country

United States

Facility Name

Saint Mary Mercy Hospital

City

Livonia

State/Province

Michigan

ZIP/Postal Code

48154

Country

United States

Facility Name

Mercy Health Mercy Campus

City

Muskegon

State/Province

Michigan

ZIP/Postal Code

49444

Country

United States

Facility Name

Newland Medical Associates-Pontiac

City

Pontiac

State/Province

Michigan

ZIP/Postal Code

48341

Country

United States

Facility Name

Saint Joseph Mercy Oakland

City

Pontiac

State/Province

Michigan

ZIP/Postal Code

48341

Country

United States

Facility Name

Spectrum Health Reed City Hospital

City

Reed City

State/Province

Michigan

ZIP/Postal Code

49677

Country

United States

Facility Name

William Beaumont Hospital-Royal Oak

City

Royal Oak

State/Province

Michigan

ZIP/Postal Code

48073

Country

United States

Facility Name

Ascension Saint Mary's Hospital

City

Saginaw

State/Province

Michigan

ZIP/Postal Code

48601

Country

United States

Facility Name

Oncology Hematology Associates of Saginaw Valley PC

City

Saginaw

State/Province

Michigan

ZIP/Postal Code

48604

Country

United States

Facility Name

Ascension Saint Joseph Hospital

City

Tawas City

State/Province

Michigan

ZIP/Postal Code

48764

Country

United States

Facility Name

Munson Medical Center

City

Traverse City

State/Province

Michigan

ZIP/Postal Code

49684

Country

United States

Facility Name

William Beaumont Hospital - Troy

City

Troy

State/Province

Michigan

ZIP/Postal Code

48085

Country

United States

Facility Name

Saint Mary's Oncology/Hematology Associates of West Branch

City

West Branch

State/Province

Michigan

ZIP/Postal Code

48661

Country

United States

Facility Name

Metro Health Hospital

City

Wyoming

State/Province

Michigan

ZIP/Postal Code

49519

Country

United States

Facility Name

IHA Hematology Oncology Consultants-Ann Arbor

City

Ypsilanti

State/Province

Michigan

ZIP/Postal Code

48197

Country

United States

Facility Name

Fairview Ridges Hospital

City

Burnsville

State/Province

Minnesota

ZIP/Postal Code

55337

Country

United States

Facility Name

Mercy Hospital

City

Coon Rapids

State/Province

Minnesota

ZIP/Postal Code

55433

Country

United States

Facility Name

Fairview Southdale Hospital

City

Edina

State/Province

Minnesota

ZIP/Postal Code

55435

Country

United States

Facility Name

Unity Hospital

City

Fridley

State/Province

Minnesota

ZIP/Postal Code

55432

Country

United States

Facility Name

Fairview Clinics and Surgery Center Maple Grove

City

Maple Grove

State/Province

Minnesota

ZIP/Postal Code

55369

Country

United States

Facility Name

Minnesota Oncology Hematology PA-Maplewood

City

Maplewood

State/Province

Minnesota

ZIP/Postal Code

55109

Country

United States

Facility Name

Saint John's Hospital - Healtheast

City

Maplewood

State/Province

Minnesota

ZIP/Postal Code

55109

Country

United States

Facility Name

Abbott-Northwestern Hospital

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55407

Country

United States

Facility Name

Hennepin County Medical Center

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55415

Country

United States

Facility Name

Health Partners Inc

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55454

Country

United States

Facility Name

New Ulm Medical Center

City

New Ulm

State/Province

Minnesota

ZIP/Postal Code

56073

Country

United States

Facility Name

North Memorial Medical Health Center

City

Robbinsdale

State/Province

Minnesota

ZIP/Postal Code

55422

Country

United States

Facility Name

Park Nicollet Clinic - Saint Louis Park

City

Saint Louis Park

State/Province

Minnesota

ZIP/Postal Code

55416

Country

United States

Facility Name

Regions Hospital

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55101

Country

United States

Facility Name

United Hospital

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55102

Country

United States

Facility Name

Saint Francis Regional Medical Center

City

Shakopee

State/Province

Minnesota

ZIP/Postal Code

55379

Country

United States

Facility Name

Lakeview Hospital

City

Stillwater

State/Province

Minnesota

ZIP/Postal Code

55082

Country

United States

Facility Name

Ridgeview Medical Center

City

Waconia

State/Province

Minnesota

ZIP/Postal Code

55387

Country

United States

Facility Name

Rice Memorial Hospital

City

Willmar

State/Province

Minnesota

ZIP/Postal Code

56201

Country

United States

Facility Name

Minnesota Oncology Hematology PA-Woodbury

City

Woodbury

State/Province

Minnesota

ZIP/Postal Code

55125

Country

United States

Facility Name

Fairview Lakes Medical Center

City

Wyoming

State/Province

Minnesota

ZIP/Postal Code

55092

Country

United States

Facility Name

Baptist Memorial Hospital and Cancer Center-Golden Triangle

City

Columbus

State/Province

Mississippi

ZIP/Postal Code

39705

Country

United States

Facility Name

Baptist Memorial Hospital and Cancer Center-Union County

City

New Albany

State/Province

Mississippi

ZIP/Postal Code

38652

Country

United States

Facility Name

Baptist Memorial Hospital and Cancer Center-Oxford

City

Oxford

State/Province

Mississippi

ZIP/Postal Code

38655

Country

United States

Facility Name

Baptist Memorial Hospital and Cancer Center-Desoto

City

Southhaven

State/Province

Mississippi

ZIP/Postal Code

38671

Country

United States

Facility Name

Capital Region Southwest Campus

City

Jefferson City

State/Province

Missouri

ZIP/Postal Code

65109

Country

United States

Facility Name

Missouri Baptist Medical Center

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63131

Country

United States

Facility Name

Mercy Hospital Springfield

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65804

Country

United States

Facility Name

CHI Health Good Samaritan

City

Kearney

State/Province

Nebraska

ZIP/Postal Code

68847

Country

United States

Facility Name

Randolph Hospital

City

Asheboro

State/Province

North Carolina

ZIP/Postal Code

27203

Country

United States

Facility Name

Mission Hospital

City

Asheville

State/Province

North Carolina

ZIP/Postal Code

28801

Country

United States

Facility Name

AdventHealth Infusion Center Asheville

City

Asheville

State/Province

North Carolina

ZIP/Postal Code

28803

Country

United States

Facility Name

Hope Women's Cancer Centers-Asheville

City

Asheville

State/Province

North Carolina

ZIP/Postal Code

28816

Country

United States

Facility Name

Gaston Hematology and Oncology Associates-Belmont

City

Belmont

State/Province

North Carolina

ZIP/Postal Code

28012

Country

United States

Facility Name

UNC Lineberger Comprehensive Cancer Center

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27599

Country

United States

Facility Name

Wake Forest University at Clemmons

City

Clemmons

State/Province

North Carolina

ZIP/Postal Code

27012

Country

United States

Facility Name

Southeastern Medical Oncology Center-Clinton

City

Clinton

State/Province

North Carolina

ZIP/Postal Code

28328

Country

United States

Facility Name

CaroMont Regional Medical Center

City

Gastonia

State/Province

North Carolina

ZIP/Postal Code

28054

Country

United States

Facility Name

Gaston Hematology and Oncology Associates

City

Gastonia

State/Province

North Carolina

ZIP/Postal Code

28054

Country

United States

Facility Name

Southeastern Medical Oncology Center-Goldsboro

City

Goldsboro

State/Province

North Carolina

ZIP/Postal Code

27534

Country

United States

Facility Name

Cone Health Cancer Center

City

Greensboro

State/Province

North Carolina

ZIP/Postal Code

27403

Country

United States

Facility Name

Margaret R Pardee Memorial Hospital

City

Hendersonville

State/Province

North Carolina

ZIP/Postal Code

28791

Country

United States

Facility Name

AdventHealth Hendersonville

City

Hendersonville

State/Province

North Carolina

ZIP/Postal Code

28792

Country

United States

Facility Name

Southeastern Medical Oncology Center-Jacksonville

City

Jacksonville

State/Province

North Carolina

ZIP/Postal Code

28546

Country

United States

Facility Name

Wake Forest University Health Sciences

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27157

Country

United States

Facility Name

Sanford Bismarck Medical Center

City

Bismarck

State/Province

North Dakota

ZIP/Postal Code

58501

Country

United States

Facility Name

Sanford Broadway Medical Center

City

Fargo

State/Province

North Dakota

ZIP/Postal Code

58122

Country

United States

Facility Name

Sanford Roger Maris Cancer Center

City

Fargo

State/Province

North Dakota

ZIP/Postal Code

58122

Country

United States

Facility Name

Strecker Cancer Center-Belpre

City

Belpre

State/Province

Ohio

ZIP/Postal Code

45714

Country

United States

Facility Name

Good Samaritan Hospital - Cincinnati

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45220

Country

United States

Facility Name

Bethesda North Hospital

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45242

Country

United States

Facility Name

TriHealth Cancer Institute-Westside

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45247

Country

United States

Facility Name

TriHealth Cancer Institute-Anderson

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45255

Country

United States

Facility Name

Columbus Oncology and Hematology Associates Inc

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43214

Country

United States

Facility Name

Riverside Methodist Hospital

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43214

Country

United States

Facility Name

Armes Family Cancer Center

City

Findlay

State/Province

Ohio

ZIP/Postal Code

45840

Country

United States

Facility Name

Marietta Memorial Hospital

City

Marietta

State/Province

Ohio

ZIP/Postal Code

45750

Country

United States

Facility Name

Licking Memorial Hospital

City

Newark

State/Province

Ohio

ZIP/Postal Code

43055

Country

United States

Facility Name

Kaiser Permanente Northwest

City

Portland

State/Province

Oregon

ZIP/Postal Code

97227

Country

United States

Facility Name

Geisinger Medical Center

City

Danville

State/Province

Pennsylvania

ZIP/Postal Code

17822

Country

United States

Facility Name

Geisinger Medical Center-Cancer Center Hazleton

City

Hazleton

State/Province

Pennsylvania

ZIP/Postal Code

18201

Country

United States

Facility Name

Geisinger Medical Oncology-Lewisburg

City

Lewisburg

State/Province

Pennsylvania

ZIP/Postal Code

17837

Country

United States

Facility Name

Geisinger Cancer Services-Pottsville

City

Pottsville

State/Province

Pennsylvania

ZIP/Postal Code

17901

Country

United States

Facility Name

Community Medical Center

City

Scranton

State/Province

Pennsylvania

ZIP/Postal Code

18510

Country

United States

Facility Name

Geisinger Medical Oncology-Selinsgrove

City

Selinsgrove

State/Province

Pennsylvania

ZIP/Postal Code

17870

Country

United States

Facility Name

Geisinger Wyoming Valley/Henry Cancer Center

City

Wilkes-Barre

State/Province

Pennsylvania

ZIP/Postal Code

18711

Country

United States

Facility Name

AnMed Health Cancer Center

City

Anderson

State/Province

South Carolina

ZIP/Postal Code

29621

Country

United States

Facility Name

Prisma Health Cancer Institute - Spartanburg

City

Boiling Springs

State/Province

South Carolina

ZIP/Postal Code

29316

Country

United States

Facility Name

Prisma Health Cancer Institute - Easley

City

Easley

State/Province

South Carolina

ZIP/Postal Code

29640

Country

United States

Facility Name

Gibbs Cancer Center-Gaffney

City

Gaffney

State/Province

South Carolina

ZIP/Postal Code

29341

Country

United States

Facility Name

Tidelands Georgetown Memorial Hospital

City

Georgetown

State/Province

South Carolina

ZIP/Postal Code

29440

Country

United States

Facility Name

Prisma Health Cancer Institute - Butternut

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Prisma Health Cancer Institute - Faris

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29605

Country

United States

Facility Name

Prisma Health Cancer Institute - Eastside

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29615

Country

United States

Facility Name

Self Regional Healthcare

City

Greenwood

State/Province

South Carolina

ZIP/Postal Code

29646

Country

United States

Facility Name

Prisma Health Cancer Institute - Greer

City

Greer

State/Province

South Carolina

ZIP/Postal Code

29650

Country

United States

Facility Name

Gibbs Cancer Center-Pelham

City

Greer

State/Province

South Carolina

ZIP/Postal Code

29651

Country

United States

Facility Name

Prisma Health Cancer Institute - Seneca

City

Seneca

State/Province

South Carolina

ZIP/Postal Code

29672

Country

United States

Facility Name

Spartanburg Medical Center

City

Spartanburg

State/Province

South Carolina

ZIP/Postal Code

29303

Country

United States

Facility Name

MGC Hematology Oncology-Union

City

Union

State/Province

South Carolina

ZIP/Postal Code

29379

Country

United States

Facility Name

Sanford Cancer Center Oncology Clinic

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57104

Country

United States

Facility Name

Sanford USD Medical Center - Sioux Falls

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57117-5134

Country

United States

Facility Name

Baptist Memorial Hospital and Cancer Center-Memphis

City

Memphis

State/Province

Tennessee

ZIP/Postal Code

38120

Country

United States

Facility Name

Baptist Memorial Hospital for Women

City

Memphis

State/Province

Tennessee

ZIP/Postal Code

38120

Country

United States

Facility Name

Family Cancer Center-Memphis

City

Memphis

State/Province

Tennessee

ZIP/Postal Code

38120

Country

United States

Facility Name

Meharry Medical College

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37208

Country

United States

Facility Name

Aurora Cancer Care-Southern Lakes VLCC

City

Burlington

State/Province

Wisconsin

ZIP/Postal Code

53105

Country

United States

Facility Name

Marshfield Clinic-Chippewa Center

City

Chippewa Falls

State/Province

Wisconsin

ZIP/Postal Code

54729

Country

United States

Facility Name

Marshfield Medical Center-EC Cancer Center

City

Eau Claire

State/Province

Wisconsin

ZIP/Postal Code

54701

Country

United States

Facility Name

Aurora Health Center-Fond du Lac

City

Fond Du Lac

State/Province

Wisconsin

ZIP/Postal Code

54937

Country

United States

Facility Name

Aurora Health Care Germantown Health Center

City

Germantown

State/Province

Wisconsin

ZIP/Postal Code

53022

Country

United States

Facility Name

Aurora Cancer Care-Grafton

City

Grafton

State/Province

Wisconsin

ZIP/Postal Code

53024

Country

United States

Facility Name

Saint Vincent Hospital Cancer Center Green Bay

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54301

Country

United States

Facility Name

Saint Vincent Hospital Cancer Center at Saint Mary's

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54303

Country

United States

Facility Name

Aurora BayCare Medical Center

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54311

Country

United States

Facility Name

Aurora Cancer Care-Kenosha South

City

Kenosha

State/Province

Wisconsin

ZIP/Postal Code

53142

Country

United States

Facility Name

Gundersen Lutheran Medical Center

City

La Crosse

State/Province

Wisconsin

ZIP/Postal Code

54601

Country

United States

Facility Name

Marshfield Clinic - Ladysmith Center

City

Ladysmith

State/Province

Wisconsin

ZIP/Postal Code

54848

Country

United States

Facility Name

Holy Family Memorial Hospital

City

Manitowoc

State/Province

Wisconsin

ZIP/Postal Code

54221

Country

United States

Facility Name

Aurora Bay Area Medical Group-Marinette

City

Marinette

State/Province

Wisconsin

ZIP/Postal Code

54143

Country

United States

Facility Name

Saint Vincent Hospital Cancer Center at Marinette

City

Marinette

State/Province

Wisconsin

ZIP/Postal Code

54143

Country

United States

Facility Name

Marshfield Medical Center-Marshfield

City

Marshfield

State/Province

Wisconsin

ZIP/Postal Code

54449

Country

United States

Facility Name

Aurora Cancer Care-Milwaukee

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53209

Country

United States

Facility Name

Aurora Saint Luke's Medical Center

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53215

Country

United States

Facility Name

Aurora Sinai Medical Center

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53233

Country

United States

Facility Name

Marshfield Clinic-Minocqua Center

City

Minocqua

State/Province

Wisconsin

ZIP/Postal Code

54548

Country

United States

Facility Name

Cancer Center of Western Wisconsin

City

New Richmond

State/Province

Wisconsin

ZIP/Postal Code

54017

Country

United States

Facility Name

Saint Vincent Hospital Cancer Center at Oconto Falls

City

Oconto Falls

State/Province

Wisconsin

ZIP/Postal Code

54154

Country

United States

Facility Name

Vince Lombardi Cancer Clinic - Oshkosh

City

Oshkosh

State/Province

Wisconsin

ZIP/Postal Code

54904

Country

United States

Facility Name

Aurora Cancer Care-Racine

City

Racine

State/Province

Wisconsin

ZIP/Postal Code

53406

Country

United States

Facility Name

Marshfield Medical Center-Rice Lake

City

Rice Lake

State/Province

Wisconsin

ZIP/Postal Code

54868

Country

United States

Facility Name

Vince Lombardi Cancer Clinic-Sheboygan

City

Sheboygan

State/Province

Wisconsin

ZIP/Postal Code

53081

Country

United States

Facility Name

Marshfield Clinic Stevens Point Center

City

Stevens Point

State/Province

Wisconsin

ZIP/Postal Code

54482

Country

United States

Facility Name

Saint Vincent Hospital Cancer Center at Sturgeon Bay

City

Sturgeon Bay

State/Province

Wisconsin

ZIP/Postal Code

54235-1495

Country

United States

Facility Name

Aurora Medical Center in Summit

City

Summit

State/Province

Wisconsin

ZIP/Postal Code

53066

Country

United States

Facility Name

Vince Lombardi Cancer Clinic-Two Rivers

City

Two Rivers

State/Province

Wisconsin

ZIP/Postal Code

54241

Country

United States

Facility Name

Marshfield Clinic-Wausau Center

City

Wausau

State/Province

Wisconsin

ZIP/Postal Code

54401

Country

United States

Facility Name

Aurora Cancer Care-Milwaukee West

City

Wauwatosa

State/Province

Wisconsin

ZIP/Postal Code

53226

Country

United States

Facility Name

Aurora West Allis Medical Center

City

West Allis

State/Province

Wisconsin

ZIP/Postal Code

53227

Country

United States

Facility Name

Marshfield Medical Center - Weston

City

Weston

State/Province

Wisconsin

ZIP/Postal Code

54476

Country

United States

Facility Name

Marshfield Clinic - Wisconsin Rapids Center

City

Wisconsin Rapids

State/Province

Wisconsin

ZIP/Postal Code

54494

Country

United States

12. IPD Sharing Statement

Plan to Share IPD

Yes

IPD Sharing Plan Description

Wake Forest National Cancer Institute Community Oncology Research Program (NCORP) Research Base is committed to following the NIH Statement on Sharing Research Data. As of July 2018, the Wake Forest (WF) NCORP Research Base (RB) signed an agreement with NCI to contribute de-identified data and data dictionaries from clinical trials conducted through our RB to the NCI National Clinical Trials Network (NCTN)/NCORP data archive within 6 months of primary and non-primary publications of phase II/III and phase III trials. This will become the primary means for sharing raw data, and we will adhere to the guidelines spelled out in the NCTN/NCORP Data Archive Usage Guide.

IPD Sharing Time Frame

See NIH Policy

IPD Sharing Access Criteria

request using link below

IPD Sharing URL

https://nctn-data-archive.nci.nih.gov/

Learn more about this trial

Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil

We'll reach out to this number within 24 hrs

Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil (Remember)

Cognitive Dysfunction, Memory Impairment

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial