Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension (ResHypOT)
Hypertension Resistant to Conventional Therapy
About this trial
This is an interventional treatment trial for Hypertension Resistant to Conventional Therapy focused on measuring Hypertension Resistant to Conventional Therapy, Natriuretic Agents, Renin-Angiotensin System, Bisoprolol
Eligibility Criteria
Inclusion Criteria:
Clinical diagnosis of Resistant Hypertension Must to able swallow antihypertensive drug classes at maximum tolerated doses.
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Exclusion Criteria:
Secondary Hypertension Chronic renal failure Coronary artery disease Atrial fibrillation Atrioventricular block Refuse or fail to follow regimen
Sites / Locations
- Juan Carlos Yugar-Toledo
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Spironolactone, Furosemide Amiloride
Ramipril, Bisoprolol
Spironolactone 25 mg qd, Furosemide 20 mg qd, Furosemide 40 mg qd, Amiloride 5 mg qd
Ramipril 5 mg qd, Ramipril 10 mg qd, Bisoprolol 5 mg qd, Bisoprolol 10 mg qd