CDH - Optimisation of Neonatal Ventilation (CDH-ONV)
Congenital Diaphragmatic Hernia
About this trial
This is an interventional treatment trial for Congenital Diaphragmatic Hernia
Eligibility Criteria
Inclusion Criteria:
- Congenital diaphragmatic hernia - post-operative Mechanically ventilated Born at >34/40
Exclusion Criteria:
- neuromuscular blockade contraindications to NG/OG tube insertion
Sites / Locations
- King's College HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
4, 5, 6ml/kg targetted tidal volume
4, 6, 5ml/kg targetted tidal volume
5, 4, 6ml/kg targetted tidal volume
5, 6, 4ml/kg targetted tidal volume
6, 5, 4ml/kg targetted tidal volume
6, 4, 5ml/kg targetted tidal volume
Randomised to receive TTV at 4ml/kg, 5ml/kg, 6ml/kg. Measurement of PTPdi
Randomised to receive TTV at 4ml/kg, 6ml/kg, 5ml/kg. Measurement of PTPdi
Randomised to receive TTV at 5ml/kg, 4ml/kg, 6ml/kg. Measurement of PTPdi
Randomised to receive TTV at 5ml/kg, 6ml/kg,4ml/kg. Measurement of PTPdi
Randomised to receive TTV at 6ml/kg, 5ml/kg, 4ml/kg. Measurement of PTPdi
Randomised to receive TTV at 6ml/kg, 4ml/kg, 5ml/kg. Measurement of PTPdi