Confocal Laser Probe to Treat Barrett's Esophagus (pCLE)
Barrett's Esophagus
About this trial
This is an interventional treatment trial for Barrett's Esophagus
Eligibility Criteria
Inclusion Criteria:
- Must be greater than 18 years of age
- currently undergoing EGD
- previous diagnosis of Barrett's Esophagus
- long-standing GERD of greater than 5 years
- undergoing therapy for previously diagnosed Barrett's Esophagus
Exclusion Criteria:
- Under 19 years of age
Sites / Locations
- Oschsner Medical Center-Kenner
- Ochsner Medical Center-Jefferson Highway
Arms of the Study
Arm 1
Other
Confocal laser endomicroscopy (pCLE)
Patients agreeing to participate in the research study will receive an additional intravenous injection during endoscopy. This dose of 2.5 mg of IV fluorescein will be administered during their EGD. Probe-based microscopy will be used to evaluate the mucosa of the esophagus and GE junction. Photographs will be taken and digitally stored. Biopsies (which are part of the routine diagnosis and surveillance of Barrett's) will be targeted based on the microscopic images. The histologic findings on the biopsy specimens will be compared to the microscopic images to determine the accuracy of the probe-based microscopy in predicting pathology.