Reducing Orthostatic Intolerance With Oral Rehydration in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients
Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Systemic Exertion Intolerance Disease (SEID)
About this trial
This is an interventional treatment trial for Chronic Fatigue Syndrome focused on measuring Chronic Fatigue Syndrome (CFS), Myalgic Encephalomyelitis (ME), Postural Tachycardia Syndrome (POTS), Neurally Mediated Syncope (NMS), Systemic Exertion Intolerance Disease (SEID), Orthostatic Intolerance (OI), Oral Rehydration Solution (ORS), Lower Body Negative Pressure (LBNP)
Eligibility Criteria
Inclusion Criteria:
- Both female and male participants are being studies
- Ages 15-29
- All subjects must fulfill criteria for Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) and include 15 with Neurally Mediated Syncope (NMS) and 15 with Postural Tachycardia Syndrome (POTS).
- ME/CFS patients with NMS will be cases with episodic symptoms of Orthostatic Intolerance (OI) associated with 3 or more episodes of abrupt loss of consciousness and postural tone within the last year (simple faint)
- ME/CFS patients with POTS will have chronic day to day symptoms of OI for at least 3 months. POTS will be confirmed by duplication of these symptoms per tilt table test
- Healthy volunteers will be included and free from any disease
Exclusion Criteria:
- all subjects will have normal physical exam and be free of all systemic disease
- no subjects will be taking neurally active or vasoactive medications. Any prior medications will be discontinued for at least 2 weeks.
Sites / Locations
- NewYork Medical College
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Normal Saline
Oral rehydration solution
Subjects will receive 1 liter of intravenous normal saline over 1 hour and on an alternate day Subjects will drink ORS solution 1 liter total by mouth over 20 minutes.
Subjects will receive 1 liter of intravenous normal saline over 1 hour and on an alternate day Subjects will drink ORS solution 1 liter total by mouth over 20 minutes.