Smoking Cessation & Opioid Dependence Treatment Integration
Smoking Cessation, Opioid Related Disorders
About this trial
This is an interventional treatment trial for Smoking Cessation focused on measuring varenicline, buprenorphine
Eligibility Criteria
Inclusion Criteria:
- enrolled in the Comprehensive Opioid Addiction Treatment (COAT) program
- report smoking >10 cigarettes per day for >1 year
- provide an expired air carbon monoxide (CO) reading of >10 parts/million (ppm)
- report interest in making a quit attempt in the next 1-6 months (Contemplation or Preparation stages via the Stage of Change; Prochaska & Diclemente, 1983)
- willing to try varenicline for smoking cessation
Exclusion Criteria:
- current engagement in any form of tobacco cessation (e.g., pharmacotherapy)
- current use of contraindicated medications (e.g., theophylline, warfarin, insulin)
- Stage of Change category as Precontemplation (no plans to quit), Action (actively trying to quit), or Maintenance (have already quit)
- self-reported seizures in the past year
- untreated cardiovascular disease
- self-report breast-feeding
- pregnancy (verified by urinalysis)
- not within 4 weeks of advancing to the next COAT group
Sites / Locations
- West Virginia University Chestnut Ridge Center
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Experimental
Weekly Opioid Tx
Biweekly Opioid Tx
Monthly Opioid Tx
Participants in this group attended an outpatient opioid clinic once per week. As part of the current study, they received 12-week dosing of varenicline per label recommendations: 0.5mg once daily (Days 1-3), 0.5 mg twice daily (Days 4-7), and 1 mg twice daily (Days 8-84). Pill form/blister pack
Participants in this group attended an outpatient opioid clinic once bi-weekly. As part of the current study, 12-week dosing of varenicline per label recommendations: 0.5mg once daily (Days 1-3), 0.5 mg twice daily (Days 4-7), and 1 mg twice daily (Days 8-84). Pill form/blister pack
Participants in this group attended an outpatient opioid clinic once per month. As part of the current study, 12-week dosing of varenicline per label recommendations: 0.5mg once daily (Days 1-3), 0.5 mg twice daily (Days 4-7), and 1 mg twice daily (Days 8-84). Pill form/blister pack