anti10a Levels in Women Treated With LMWH in the Postpartum Period

anti10a Levels in Women Treated With LMWH in the Postpartum Period for Preventing Vein Thrombosis Events: A Comparison of Two Doses

The aim of this study is to compare between anti-10a levels in postpartum women receiving different prophylactic doses of LMWH: one group with LMWH doses adjusted by the women's weight and the second group receiving 1mg/kg to a maximum dose of 120 mg

pregnancy and postpartum period are associated with increased risk of thromboembolism. this risk is further increased in women with thrombophilia. This risk is higher in the postpartum period compared with pregnancy period, especially the risk for pulmonary embolism (PE). The American College Of Obstetrics and Gynecologists, The American college of chest physicians and The Royal College of obstetricians and gynecologists recommend using low molecular weight heparin during the postpartum period in women with thrombophilia and women with risk factor for developing thromboembolism. there is no specific guidelines regarding the best protocol based on the level of anti-10 a. This study will compare between two protocols based on anti-10a levels.

clexane dose adjusted for woman's weight according to: weight < 90 kg - 40mg, 91-130kg - 60 mg, 131-170kg - 80mg, >170kg-100mg.

Inclusion Criteria: postpartum women supposed to receive LMWH according to obstetric indications Exclusion Criteria: known allergy to clexane active bleeding postpartum thrombocytopenia < 75000 recent cerebrovascular accident / transient ischemic attack (<4 weeks) glomerular filtration rate) < 30 ml/min) active liver disease malignant hypertension (systolic > 200 mmHg, diastolic> 120 mmHg)

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