A Study to Investigate the Antimicrobial Activity of 2 Test Toothpastes
Dental Plaque
About this trial
This is an interventional basic science trial for Dental Plaque
Eligibility Criteria
Inclusion Criteria:
- Demonstrates understanding of the study procedures, restrictions and willingness to participate as evidenced by voluntary written informed consent and has received a signed and dated copy of the informed consent form.
- Good general and mental health with, in the opinion of the investigator or medically qualified designee no clinically significant and relevant abnormalities in medical history or upon oral examination.
- Plaque sample acidogenicity in the pH range 5.0 to 5.7 at Visit.
Exclusion Criteria:
- Women who are known to be pregnant or who are intending to become pregnant over the duration of the study.
- Women who are breast-feeding.
- Currently taking antibiotics or have taken antibiotics within 2 weeks of plaque assessment (Visit 2). A participant with any medical history that may prevent them from participating in the study until study conclusion (such as diabetes).
- Any sign of grossly carious lesions (active), moderate or severe periodontal conditions, or severe tooth wear.
- Known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients.
- Current smokers, or smokers who have quit within 6 months of screening, or participants currently using smokeless forms of tobacco, e.g. Gutkha, Pan containing tobacco, Pan Masala.
- Current active caries or periodontitis that may compromise, in the opinion of the investigator, study outcomes or the health of the subject.
- Restorations in a poor state of repair that may, in the opinion of the investigator, compromise study outcomes or the health of the participant.
- Partial dentures or orthodontic appliances that may, in the opinion of the investigator, compromise study outcomes or the health of the participant.
- Recent history (within the last year) of alcohol or other substance abuse.
Sites / Locations
- GSK Investigational Site
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Active Comparator
Active Comparator
Active Comparator
Test zinc-IPMP toothpaste
Test zinc non- IPMP toothpaste
Positive control Toothpaste
SLS Negative Control
non-SLS negative control
Rinse with preprepared slurry of toothpaste in 10 milliliter (mL) water for 60 seconds(s) followed by rinse with 10mL water
Rinse with preprepared slurry of toothpaste in 10 mL water for 60s followed by rinse with 10mL water
Rinse with preprepared slurry of toothpaste in 10 mL water for 60s followed by rinse with 10mL water
Rinse with preprepared slurry of toothpaste in 10 mL water for 60s followed by rinse with 10mL water
Rinse with preprepared slurry of toothpaste in 10 mL water for 60s followed by rinse with 10mL water