SI + CC Versus 3:1 C:V Ratio During Neonatal CPR (SURV1VE)
Heart Arrest, Birth Asphyxia, Bradycardia
About this trial
This is an interventional treatment trial for Heart Arrest focused on measuring Chest Compression, Newborn, Infant, Sustained Inflation
Eligibility Criteria
Inclusion Criteria:
- Infants (term or preterm infants >28 weeks' gestation) requiring CC in the delivery room will be eligible for the trial.
Exclusion Criteria:
- Infants will be excluded if they have a congenital abnormality or condition that might have an adverse effect on breathing or ventilation (e.g. congenital diaphragmatic hernia), or congenital heart disease requiring intervention in the neonatal period. Infants would be also excluded if their parents refused to give consent to this study.
Sites / Locations
- Medical University Graz
- Medical University Vienna
- Royal Alexandra Hospital
- IWK Health Centre
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Intervention (CC+SI)
Control (3:1 C:V)
Infants randomized into the "CC+SI group" will receive a SI with a PIP of 25-30 cmH2O while receiving chest compression. The SI will be delivered over a period of 45 seconds. This will be followed by PEEP of 5-8 cm water to perform an assessment of the newborn's heart rate. If heart rate is >60/min continue with standard care as per local hospital policy (standard hospital practice guideline). If heart rate remains <60/min continue with CC+SI for another 45sec at which time a further assessment should be performed. If heart rate remains <60/min continue with CC+SI.
Infants randomized into the "3:1 C:V group" will receive CC at a rate of 90/min and 30 ventilations/min in a 3:1 C:V ratio as recommended by the current resuscitation guidelines.