Eating Behaviour and Gustatory Sensitivity Before and After Liver Transplant in Cirrhotic Patients (GREFFE)

Today, we know that olfactogustatory alterations occur in cirrhotic patients before the liver transplant but no study has been conducted to show eventual disturbances after the transplantation able to explain modifications in eating behaviour. In parallel, the metabolic status, itself dependent on liver metabolism, influences food preferences and is modified after the transplantation as the liver recovers its ability to store glycogen, but is not able to inform the brain as the afferent nerve impulses have been suppressed. The innovative aspect of this project is to provide information on the importance of the liver in the regulation of energy homeostasis. The results of this study will improve our understanding of eating behaviour and olfactogustatory sensitivity and allow us to orient liver transplant patients towards appropriate diets.

Inclusion Criteria: persons who have provided written informed consent persons aged between 18 and 70 years persons waiting for a liver transplantation (group LT) persons with stable liver damage persons waiting for a kidney transplantation (KT) healthy subjects (control group) no known disease Exclusion Criteria: persons without national health insurance cover persons with chronic infection, persons with acute infection, persons with progressive cancer, persons with an antibiotic treatment, persons who drink alcohol, pregnant or breast-feeding women, persons with an aversion to the foods proposed in the study, persons taking treatments known to interfere with gustatory and olfactory performance, adults under guardianship