Garcinia Mangostana L.Pericarp Gel as a Local Drug Delivery in Treatment of Chronic Periodontitis
Generalized Chronic Periodontitis
About this trial
This is an interventional treatment trial for Generalized Chronic Periodontitis focused on measuring Anti-inflammatory agents, antimicrobials, Periodontitis
Eligibility Criteria
Inclusion Criteria:
- Age: 30 to 65 years
- Systemically healthy subjects with chronic periodontitis
Exclusion Criteria:
- aggressive periodontitis,
- systemic disorders,
- known or suspected allergy to the MGA/placebo group,
- pregnant and lactating females,
- long term steroid medication,
- smokers,
- alcoholics,
- immunocompromised individuals and
- those with history of antibiotic or periodontal therapy in preceding 6 months
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Garcinia Mangostana
Placebo gel
The constituents of mangostana containing gel were prepared under the following proportions: Mangostana powder - 4gm, Gelatin - 12gm, Glycerin (wetting agent) - 0.2ml, Peppermint oil (flavouring agent) - 0.1ml, sodium saccharine (sweetening agent) - 0.1ml and purified water q.s 100ml.
The placebo gel was prepared with Gelatin - 12gm, Glycerin (wetting agent) - 0.2ml, Peppermint oil (flavouring agent) - 0.1ml, sodium saccharine (sweetening agent) - 0.1ml and purified water q.s 100ml excluding the active ingredient mangostana powder - 4 mg and maintaining same physical properties such as color and taste.