Predicting Antipsychotic Discontinuation in Psychosis (PADP)
Schizophrenia
About this trial
This is an interventional treatment trial for Schizophrenia focused on measuring dopamine receptor occupancy, antipsychotics, positron emission tomography
Eligibility Criteria
Inclusion Criteria:
1. Patient group
- Patients who met DSM-IV criteria for schizophrenia, schizoaffective disorder, and schizophreniform disorder
- patients diagnosed with first episode psychosis which occurred within 2 years and having been treated with antipsychotics for at least 1 year.
- Patients who have maintained in the stable state for 3 months without medication change at the baseline.
2. Healthy control group
- Healthy controls has no Axis I disorder and do not report any past event of neurological or psychiatric illness assessed by the Structured Clinical Interview for DSM Disorders
Exclusion Criteria:
- Participants should not have any neurological illness such as head trauma, seizure and meningitis.
- Participants should not be diagnosed as Mental retardation(IQ<70)
- Participants should not have severe personality disorder, substance abuse or dependence (except for nicotine abuse and dependence) and severe medical conditions.
Sites / Locations
- Seoul National University Bundang Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Other
patient group
healthy control group
The patient group recruits subjects diagnosed with first episode psychosis which occurred within 2 years and having been treated with antipsychotics for 1 year. Subjects in the patient group will receive a reduced intake of antipsychotics by 25% after each week of the four-week period in which they will also undergo PET imaging at the baseline, 7 week, and 8 week marks to detect the correlation between the capacity. And patient group should complete clinical scales at 0, 2, 4, 6, and 8 week.
Screening tests for healthy volunteers included physical examination, vital signs, laboratory will test (hematology, blood chemistry, and urinalysis), and a 12-lead electrocardiograms. A psychiatric interview with the Structured Clinical Interview for text revision of the Diagnostic and Statistical Manual of Mental Disorders -IV(DSM-IV-TR) Axis I disorders, Research Version, Nonpatient Edition (SCID-I/NP) (First et al. 2002) will be conducted. Subjects with any medically significant abnormality on investigations and/or psychiatric disease will be excluded. Also, healthy control group will take a PET scan at 0, 2, 4, 6, and 8 week and clinical scales at baseline.