Behavioral Economic Purchasing Decisions for Cigarettes of Varied Compositions
Tobacco Use Disorder, Substance-Related Disorders
About this trial
This is an interventional basic science trial for Tobacco Use Disorder focused on measuring Tobacco withdrawal, Autonomic Agents
Eligibility Criteria
Inclusion Criteria:
- Age 18 years or older
- Smoke at least five cigarettes per day
- Have an expired carbon monoxide level of more than 8 ppm or a urinary cotinine level of more than 100 ng per milliliter
- Have a Fagerström Test for Nicotine Dependence score of at least 5 upon screening
Exclusion Criteria:
- The intention to quit smoking in the next 30 days
- The use of other tobacco products in addition to machine-manufactured cigarettes on more than 9 of the previous 30 days
- Use of "roll your own" cigarettes as an exclusive form of smoking
- A serious medical or psychiatric disorder or unstable condition
- Any positive toxicological screening for illicit drugs other than cannabis will be excluded
- Women who are pregnant, plan to become pregnant or are breast-feeding
Sites / Locations
- Johns Hopkins University School of Medicine, Bayview Campus
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Cigarette W
Cigarette X
Cigarette Y
Cigarette Z
Altered composition cigarettes moisture = 12.20 %, tar = 10.40 mg/cigarette, total particulate matter = 12.0 mg/cigarette, high sugar content
Altered composition cigarettes moisture = 12.10 %, tar = 8.60 mg/cigarette, total particulate matter = 9.60 mg/cigarette, low sugar content
Altered composition cigarettes moisture = 13.20 %, tar = 9.10 mg/cigarette, total particulate matter = 10.10 mg/cigarette, low sugar content
Altered composition cigarettes moisture = 13.60 %, tar = 8.10 mg/cigarette, total particulate matter = 9.10 mg/cigarette, low sugar content