Comparison of Laparoscopic Proximal Gastrectomy and Laparoscopic Total Gastrectomy
Gastric Cancer
About this trial
This is an interventional treatment trial for Gastric Cancer
Eligibility Criteria
Inclusion Criteria:
- Patients are included in the trial if they meet all of the following criteria:
Histologically proven adenocarcinoma through endoscopic biopsy Aged 20-80 years old Written signed informed consent No other malignancies Proximal gastric cancer met by following conditions ; Lesion located on proximal stomach (upper one third) Lesion below 5cm in size Lesion confined to mucosa or submucosa (cT1) No evidence of metastatic enlarged LN on #5, 6, 4d, 10 basins and other distant metastasis.
Performance status (PS) of 0 or 1 on Eastern Cooperative Oncology Group (ECOG) scale Performance status (PS) of I to III on American Society of Anesthesiologists (ASA) score
Exclusion Criteria:
- Patients are excluded if they meet any of the following criteria:
History of anemia Patients who need total gastrectomy History of pre-operative chemotherapy or radiation therapy for gastric cancer Patients who need combined resection (except cholecystectomy) Presence of other malignancies Prior treatment against systemic inflammatory disease Previous gastric surgery Vulnerable patients (lack of decision-making capacity, pregnant, or breast-feeding women)
Sites / Locations
- Soonchunhyang University Bucheon Hospital
- Dong-A University Hospital
- Dankook University Hospital
- Keimyung University Hospital
- Chungnam National University Hospital
- Eulji University Hospital, Deajon
- Chonnam National University Hospital
- National Cancer Center
- Pusan National University Hospital
- Seoul National University Bundang Hospital
- Ewha Womans University Medical Center
- Seoul National University Hospital
- Seoul St. Mary's Hospital
- Yeouido St. Mary's Hospital
- Yonsei University Severance Hospital
- Ajou University Hospital
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Laparoscopic proximal gastrectomy
Laparoscopic total gastrectomy
Laparoscopy proximal gastrectomy with esophago-jejunostomy, gastro-jejunostomy and jejuno-jejunostomy (double tract reconstruction). Systemic en bloc lymph node dissection is mandatory. Resection margin should be negative for malignancy with intraoperative frozen biopsy.
Laparoscopic total gastrectomy with esophago-jejunostomy and jejuno-jejunostomy (Roux-en-Y reconstruction). Systemic en bloc lymph node dissection is mandatory. Resection margin should be negative for malignancy with intraoperative frozen biopsy.