Hyperbaric Oxygen Therapy Improves Outcome of Hypoxic-Ischemic Encephalopathy

This is an interventional treatment trial for Hypoxic-ischemic Encephalopathy focused on measuring hypoxic-ischemic encephalopathy, hyperbaric oxygen therapy Read More

• Inclusion Criteria:

  • Newborn infants whose gestational age ≥37 weeks' gestation, weighing over 2500 g ;
  • Acute perinatal event (e.g., late or variable decelerations, cord prolapse, cord rupture, uterine rupture, maternal trauma, hemorrhage, or cardiorespiratory arrest)
  • With an Apgar score ≤ 3 at one minute and ≤5 at five minutes, and/or a potential of hydrogen of 7.0 or less or a base deficit of 16 mmol per liter or more in a sample of umbilical-cord blood or any blood during the first hour after birth.
  • Having moderate-to-severe encephalopathy (indicated by lethargy, stupor, or coma) and either hypotonia, abnormal reflexes (including oculomotor or pupillary abnormalities), an absent or weak suck, or clinical seizures, and/or have abnormal background activity of at least 20 minutes' duration or seizures on amplitude integrated electroencephalography

• Exclusion Criteria:

  • A congenital and the hereditary disease, a chromosome abnormalities, and a congenital abnormality.
  • During the acute phases of intracranial and (or) fundus hemorrhage. o
  • Intracranial infection.
  • Pneumothorax.
  • Infants who have been received hypothermia.