YAG Vitreolysis for Floaters
Weiss Ring, Floaters, Posterior Vitreous Detachment
About this trial
This is an interventional treatment trial for Weiss Ring
Eligibility Criteria
Inclusion Criteria:
- Symptoms of floaters that correlate to the presence of a posterior vitreous detachment for at least 6 months
- Documented posterior vitreous detachment on clinical examination, OCT, and B scan
- Self-rating of visual disturbance by the floaters must be at least 4 on a 0-10 scale, with 0 being no symptoms to 10 being debilitating symptoms.
- Symptomatic Weiss ring (PVD) must be at least 3 mm away from the retina and 5 mm from the posterior lens capsule of the crystalline lens, as measured on B-scan. For pseudophakic patients, there is no minimum required distance from the intraocular lens.
- Able to position for the YAG laser procedure.
- Accept the risks of YAG laser including but not limited to retinal detachment, intraocular hemorrhage, retinal damage, cataract formation, optic nerve damage, inflammation, and irreversible loss of vision.
- Willing and able to comply with clinic visits and study-related procedures
- If the patient has two symptomatic eyes, only one eye can be randomized and included in the study.
- Provide signed informed consent
Exclusion Criteria:
- Snellen best corrected visual acuity worse than 20/50 in the fellow eye
- History of retinal tear, retinal detachment, or uveitis in the study eye
- History of diabetic retinopathy, macular edema, retinal vein occlusion, or aphakia in the study eye
- History of glaucoma or high intraocular pressure defined as having a history of glaucoma surgery or currently taking two or more topical glaucoma medications in the study eye
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
YAG vitreolysis
Sham YAG vitreolysis
A Karickoff lens with goniosol will be used to perform the YAG vitreolysis. The number of shots will be determined at the discretion of the treating physician. A focus offset may be used at investigator discretion. Single shot mode will be used. The maximum energy per pulse will be 7 mJ. The endpoint of treatment is the vaporization of the Weiss ring into gas, as well as the disruption of it into smaller fragments as well as any other vitreous opacities deemed visually significant by the treating physician. Only one treatment session will be performed.
Sham laser treatment will be applied under the same procedure used for laser treatment but by turning the laser power down to 0.3 mJ and using a separate lens covered by a filter that absorbs the power, so no laser enters the eye.