Clinical Value of Heart Rate Variability Indexes to Predict Outcomes After Exercise Training in Chronic Heart Failure (REINCA)
Heart Failure, Systolic Heart Failure
About this trial
This is an interventional treatment trial for Heart Failure focused on measuring Heart rate variability, Systolic heart failure, Physical exercise, Parasympathetic indexes
Eligibility Criteria
Inclusion Criteria:
- subjects followed in a University Heart Failure Management Program
- maintained sinus rhythm
- New York Heart Association Functional Class (NYHA) I to III and
- LVEF≤40% documented by echocardiogram
- optimal pharmacologic treatment
Exclusion Criteria:
- history of stroke, myocardial infarction or extended anterior myocardial scar
- revascularization procedures or recurrent angina within previous 3 months
- orthopedic impairment
- alcohol or drug abuse;
- implant of pacemaker or cardioverter-defibrillator (AICD);
- frequently ventricular dysrhythmias,
- atrial flutter or fibrillation
- insulin-dependent diabetes mellitus;
- severe chronic obstructive pulmonary disease or renal dysfunction
- comorbid non-cardiac disease limiting short term survival
- previous enrollment in an ET program
- subjects at great propensity for noncompliance
Sites / Locations
Arms of the Study
Arm 1
Arm 2
No Intervention
Active Comparator
Usual Care
Cardiac Rehabilitation
usual care and no changes in their previous physical activity
Exercise Training program on a 3-days/week basis during 24 weeks (68-74 sessions). Each session started with a 10-min warm-up walking period followed by 20-min of breathing exercises and free non-resistance movements of limbs. This stage was followed by pedaling during 20-minutes at a circuit resistance training protocol using a stationary cycle-ergometer. Each session ended with a cool down period (5-minutes) including diverse stretching maneuvers of engaged muscle groups. The initial bicycle-ergometer workload (WL) was defined as 50% of the maximum achieved in the previous stress testing