Effect of Wound Infiltration by Ketamine Versus Dexmedetomidine Added to Bupivacaine on Surgical Stress
Abdominal Cancer
About this trial
This is an interventional health services research trial for Abdominal Cancer
Eligibility Criteria
Inclusion Criteria:
- American Society of Anesthesiologists (ASA) class I-II Body weight of 50 - 90 kg
Exclusion Criteria:
- History of bleeding diathesis
- Relevant drug allergy, opioid dependence
- Morbid obesity, sepsis
Sites / Locations
- South Egypt Cancer Instuite
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Placebo Comparator
ketamine group
dexmedetomidine group
bupivacaine group
intervention: local wound infiltration 30 patients receive local anesthetic wound infiltration with with 20 ml of bupivacaine 0.5 % diluted in 20 ml saline +1 mg /kg ketamine (total volume 40 ml) in two divided doses i.e. 20 ml is administered on each side of incision.
intervention: local wound infiltration 30 patients receive local anesthetic wound infiltration with with 20 ml of bupivacaine 0.5 % diluted in 20 ml saline + 1µg/kg dexmedetomidine (total volume 40 ml) in two divided doses i.e. 20 ml is administered on each side of incision.
intervention: local wound infiltration 30 patients receive local anesthetic wound infiltration with with 20 ml of bupivacaine 0.5 % diluted in 20 ml saline (total volume 40 ml) in two divided doses i.e. 20 ml is administered on each side of incision( control group).