Back to resultsStudy of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer (BEACON CRC)
Primary Purpose
BRAF V600E-mutant Metastatic Colorectal Cancer
Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Encorafenib
Binimetinib
Cetuximab
Irinotecan
Folinic Acid
5-Fluorouracil
Sponsored by
About this trial
This is an interventional treatment trial for BRAF V600E-mutant Metastatic Colorectal Cancer focused on measuring Colorectal cancer, BRAF, BRAFV600E
Eligibility Criteria
Key Inclusion Criteria:
- Age ≥ 18 years at time of informed consent
- Histologically- or cytologically-confirmed CRC that is metastatic
- Presence of BRAFV600E in tumor tissue as previously determined by a local assay at any time prior to Screening or by the central laboratory
- Progression of disease after 1 or 2 prior regimens in the metastatic setting
- Evidence of measurable or evaluable non-measurable disease per RECIST, v1.1
- Adequate bone marrow, cardiac, kidney and liver function
- Able to take oral medications
- Female patients are either postmenopausal for at least 1 year, are surgically sterile for at least 6 weeks, or must agree to take appropriate precautions to avoid pregnancy from screening through follow-up if of childbearing potential
- Males must agree to take appropriate precautions to avoid fathering a child from screening through follow-up
Key Exclusion Criteria:
- Prior treatment with any RAF inhibitor, MEK inhibitor, cetuximab, panitumumab or other epidermal growth factor receptor (EGFR) inhibitors
- Prior irinotecan hypersensitivity or toxicity that would suggest an inability to tolerate irinotecan 180 mg/m2 every 2 weeks
- Symptomatic brain metastasis or leptomeningeal disease
- History or current evidence of retinal vein occlusion or current risk factors for retinal vein occlusion (e.g., uncontrolled glaucoma or ocular hypertension, history of hyperviscosity or hypercoagulability syndromes)
- Known history of acute or chronic pancreatitis
- History of chronic inflammatory bowel disease or Crohn's disease requiring medical intervention (immunomodulatory or immunosuppressive medications or surgery) ≤12 months prior to randomization
- Uncontrolled blood pressure despite medical treatment
- Impaired GI function or disease that may significantly alter the absorption of encorafenib or binimetinib (e.g., ulcerative diseases, uncontrolled vomiting, malabsorption syndrome, small bowel resection with decreased intestinal absorption)
- Concurrent or previous other malignancy within 5 years of study entry, except cured basal or squamous cell skin cancer, superficial bladder cancer, prostate intraepithelial neoplasm, carcinoma in-situ of the cervix, or other noninvasive or indolent malignancy
- History of thromboembolic or cerebrovascular events ≤ 6 months prior to starting study treatment, including transient ischemic attacks, cerebrovascular accidents, deep vein thrombosis or pulmonary emboli
- Concurrent neuromuscular disorder that is associated with the potential of elevated creatine (phosphor)kinase (CK) (e.g., inflammatory myopathies, muscular dystrophy, amyotrophic lateral sclerosis, spinal muscular atrophy)
- Residual common terminology criteria for adverse events (CTCAE) ≥ Grade 2 toxicity from any prior anticancer therapy, with the exception of Grade 2 alopecia or Grade 2 neuropathy
- Known history of HIV infection
- Active hepatitis B or hepatitis C infection
- Known history of Gilbert's syndrome
- Known contraindication to receive cetuximab or irinotecan at the planned doses
Sites / Locations
- Mayo Clinic Hospital
- Mayo Clinic
- Mayo Clinic
- City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
- Compassionate Care Research Group, Inc. at Compassionate Cancer Care Medical Group, Inc.
- Keck Hospital of USC - Norris Healthcare Center (HC3)
- Keck Hospital of USC
- LAC+USC Medical Center
- Norris Healthcare Center 3 (HC3)
- USC Eye Institute
- USC/Norris Comprehensive Cancer Center
- Hoag Memorial Hospital Presbyterian
- Harvard Eye Associates
- Rocky Mountain Lions Eye Institute
- University of Colorado Cancer Center - Anschutz Cancer Pavilion
- University of Colorado Denver CTO (CTRC)
- University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP)
- University of Colorado Hospital Inpatient Pavillion'
- Smilow Cancer Hospital at Yale - New Haven
- Temple Medical Center
- Yale University, Yale Cancer Center
- Smilow Cancer Hospital Care Center at North Haven
- The Lennar Foundation Medical Center
- Broward Health Medical Center
- Dr. Clayton Berger (opthalmology)
- Mehmet F. Hepgur, MD - Broward Health Medical Center
- Mayo Clinic Florida
- Sylvester Comprehensive Cancer Center/UMHC
- Sylvester at Kendall
- Illinois CancerCare- Bloomington
- University of Chicago Medical Center
- Illinois CancerCare- Galesburg
- University of Chicago Comprehensive Cancer Center at Silver Cross Hospital
- The University of Chicago Medicine Center for Advanced Care Orland Park
- Illinois CancerCare- Ottawa
- Illinois Cancer Care, PC
- Illinois Eye Center
- Carle Cancer Center
- Indiana University Health Hospital
- Indiana University Health Melvin and Bren Simon Cancer Center
- Investigational Drug Services IUHSCC
- Sidney &Lois Eskenazi Hospital
- IU Health Springmill
- Baptist Health Floyd Cancer Center
- University of Iowa Hospitals and Clinics
- The University of Kansas Clinical Research Center
- The University of Kansas Hospital
- KU Eye
- The University of Kansas Cancer Center and Medical Pavilion
- The University of Kansas Cancer Center, Investigational Drug Services
- Ochsner Clinic Foundation
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- The Investigational Drug Pharmacy (IDS) in the Sidney Kimmel Cancer Center at Johns Hopkins
- The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Massachusetts General Hospital
- Ophthalmic Consultants of Boston Inc
- Brigham & Women's Hospital
- Dana-Farber Cancer Institute (DFCI)
- Dana-Farber Cancer Institute
- Mayo Clinic
- Siteman Cancer Center - West County
- SSM Health Saint Louis University Hospital
- Barnes Jewish Hospital
- Saint Louis University
- SSM Health Saint Louis University Hospital
- Washington University Infusion Center Pharmacy
- Washington University School of Medicine
- Siteman Cancer Center - South County
- Siteman Cancer Center - St Peters
- Memorial Sloan Kettering: Basking Ridge
- Memorial Sloan Kettering: Commack
- Memorial Sloan Kettering Cancer Center
- Memorial Sloan Kettering: Rockefeller Outpatient Pavilion
- Gabrail Cancer Center Research
- Cleveland Clinic Taussig Cancer Institute
- Casey Eye Institute-South Waterfront
- OHSU Center for Health and Healing
- OHSU Research Pharmacy Services
- Oregon Health and Science University
- Henry-Joyce Cancer Clinic
- Vanderbilt Eye Institute
- The University of Texas MD Anderson Cancer Center
- Scott & White Clinic - Temple Pavilion
- Scott & White Medical Center - Temple
- Medical Oncology Associates, PS DBA Summit Cancer Centers
- Spokane Eye Clinic
- Inland Imaging, LLC Holy Family Hospital
- Medical Oncology Associates, PS DBA Summit Cancer Centers
- Providence Holy Family Nuclear Medicine
- University of Wisconsin Clinical Science Center
- CLINICA PERGAMINO S.A. (Centro de Investigacion Pergamino S.A.)
- Centro Medico INFINITO
- Centro Medico CAIPO (Centro para la Atención del paciente Oncológico)
- Clinica Universitaria Reina Fabiola
- Centro Oncologico Riojano Integral - CORI
- St Vincent's Clinic
- St Vincent's Hospital Sydney
- Marsden Eye Specialists
- Newcastle Eye Centre
- Mater Misericordiae Limited
- Central Adelaide Local Health Network Inc. operating as Royal Adelaide Hospital
- Flinders Medical Centre
- Central Adelaide Local Health Network Inc. operating as The Queen Elizabeth Hospital
- Monash Health Translation Precinct - Monash Health
- Austin Health
- Peter MacCallum Cancer Centre
- Klinikum Wels - Grieskirchen GmbH, Abteilung fuer Innere Medizin IV
- Klinikum Wels-Grieskirchen GmbH, Abteilung fuer Augenheilkunde und Optometrie
- Klinikum Wels-Grieskirchen GmbH, Abteilung fuer Innere Medizin II
- Klinikum Wels-Grieskirchen GmbH, Institut fuer Nuklearmedizin
- Klinikum Wels-Grieskirchen GmbH, Institut fuer Radiologie I
- DZU, Diagnose Zentrum Urania GmbH
- AKH Wien
- Medizinische Universitaet Wien/AKH Wien
- Medizinische Universität Wien/AKH Wien
- Centre Hospitalier de l'Ardenne - Site de Libramont
- AZ Sint-Jan Brugge - Oostende AV - Campus Sint-Jan - Oncology
- Imelda Ziekenhuis
- Grand Hopital de Charleroi (GHdC)
- UZ Antwerpen
- AZ Maria Middelares
- University Hospital Gasthuisberg (UZ Leuven)
- Centre Hospitalier Universitaire (CHU) de Liege
- CHC Saint Joseph
- AZ Delta Roeselaere-Menen
- Centre Hospitalier Regional (CHR) - Verviers
- Hospital do Olho
- CENOB - Centro de Oncologia da Bahia SS Ltda / Oncovida
- CEMES Centro Medico Especializado em Oftalmologia
- Centro de Pesquisas Clínicas em Oncologia
- Hospital Evangelico de Cachoeiro de Itapemirim
- Instituto Vizibelli
- CENANTRON - Centro Avancado de Tratamento Oncologic
- Fundação Universidade de Caxias do Sul
- Daniel Lubisco Pandolfi
- Sociedade Beneficencia e Cardade de Lajeado/Hospital Bruno Born
- Sociedade Beneficencia e Cardade de Lajeado/Hospital Bruno Born
- Associacao Hospitalar Beneficente Sao Vicente de Paulo / Hospital Sao Vicente de Paulo
- Consultorio Medico de Oftalmologia - Dr. Ricardo Tres
- Hospital Sao Vicente de Paulo
- Thiago Vernetti Ferreira
- Leandro Becker
- Fernanda Mendes
- UPCO - Unidade de Pesquisas Clinicas em Oncologia
- Fernanda Lauermann
- Diogo Duarte Torre
- Farmacia Central da Irmandade da Santa Casa de Misericordia de Porto Alegre
- Irmandade da Santa Casa de Misericordia de Porto Alegre
- Nucleo de Novos Tratamentos em Cancer
- Centro de Pesquisa Clínica de Oncologia e Hematologia - Hospital Mãe de Deus/AESC
- Clinica de Oftalmologia Lavinsky
- Hospital Mãe de Deus
- Clinica Toller
- Olhos Centro Diagnostico e Laser LTDA
- Fundacao Pio XII
- Giuliano Santos Borges - ME / Clinica de Neoplasias Litoral - Centro de Novos Tratamentos Itajai
- FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC
- FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC
- Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
- CEPOS - Centro de Estudos e Pesquisas Oncologicas de Sorocaba
- Instituto de Oncologia de Sorocaba "Dr. Gilson Delgado"
- Karen Miyuki Kubokawa Shorer
- Oftalmologia Diagnostica de Sorocaba (ODS)
- Instituto de Ensino e Pesquisa São Lucas
- Instituto de Ensino e Pesquisa São Lucas - Pharmacy
- Hospital Leforte
- IPEPO - Instituto da Visao
- Eye Care Centre, Vancouver General Hospital
- BC Cancer, Vancouver Center
- The Ottawa Hospital Cancer Centre
- Sunnybrook Research Institute
- Mount Sinai Hospital
- Centre integre universitaire de sante et de services sociaux de l'Ouest-de-l'Ile-de-Montreal
- Instituto Clinico Oncologico del Sur (ICOS)
- Hospital Clinico Vina Del Mar
- Ocni ordinace Oftalpro s.r.o.
- Masarykuv onkologicky ustav
- Fakultni nemocnice Hradec Kralove
- Fingerlanduv ustav patologie
- I. interni kardioangiologicka klinika
- Klinika nemoci koznich a pohlavnich
- Nemocnicni lekarna - Usek klinickych studii
- Ocni klinika
- Radiologicka klinika
- Fakultni nemocnice Olomouc, I. interni klinika - kardiologicka
- Fakultni nemocnice Olomouc, Lekarna
- Fakultni nemocnice Olomouc
- Odense University Hospital (OUH)
- Hopital Jean Minjoz
- CHU Morvan
- Centre Ophtalmologique - Pole Vision - Clinique Val d'Ouest
- Centre Leon Berard
- ICM Val d'Aurelle
- CHU HOTEL-Dieu
- Centre hospitalier national d'ophtalmologie des Quinze-Vingts
- Centre Hospitalier National d'Opthalmologie des Quinze-Vingts (CHNO des XV-XX)
- Hopital Georges Pompidou
- CHU Robert Debre
- SCM Centre d'ophtalmologie
- CHU Toulouse-Institut Inuversitaire du Cancer Toulouse
- CHU Toulouse-Rangueil
- CHU Toulouse - Purpan, hopital Pierre-Paul Riquet
- Gustave Roussy
- Universitaetsklinikum Tuebingen
- Universitaetsklinikum Ulm
- Augenklinik der Universitaet Muenchen
- LMU Klinikum der Universitaet Muenchen, Campus Grosshadern
- Augenarzt-Gemeinschaftspraxis Dr.med.Andreas Kind & Dr.med. Ute Kariger-Schweigert
- Medizinische Hochschule Hannover (MHH)
- Medizinische Hochschule Hannover
- Kliniken Essen Mitte / Knappschaftskrankenhaus
- Praxis fuer Augenheilkunde Dr. Edmund Meyer-Schwickerath
- Kliniken Essen-Mitte
- Universitaetsklinikum Essen (AoeR), Innere Klinik (Tumorforschung), Westdeutsches Tumorzentrum
- Universitaetsklinikum Essen; Diagnostischeu. Interventionelle Radiologie u. Neuroradiologie
- Universitaetsklinikum Essen; Nuklearmedizin
- Universitaetsklinikum Essen; Zentralapotheke
- Evang. Krankenhaus Essen - Werden; Klinik fuer Augenheilkunde
- Kliniken Essen Mitte / Knappschaftskrankenhaus
- Augentagesklinik Maria-Hilf Krankenhaus
- Kliniken Maria Hilf GmbH - Franziskuskrankenhaus
- Kliniken Maria Hilf GmbH; Klinik fuer Radiologie
- Lukaskrankenhaus Neuss; Zentrale Apotheke
- Institut f. Pathologie - Ruhr-Universitaet Bochum, Prof. Dr. med. Andrea Tannapfel
- Augenarzt Praxis Dr. med. Petra Huelsmann
- Gemeinschaftspraxis fuer Radiologie und Nuklearmedizin, Standort Worms
- Martin Apotheke
- Onkologische Schwerpunktpraxis Worms
- Praxisgemeinschaft Kruse + Hofstaetter
- Evangelisches Waldkrankenhaus Spandau
- Universitaetsklinikum Carl Gustav Carus der Technischen Universitaet Dresden
- Universitaetsklinikum Hamburg Eppendorf, Klinik fuer Augenheilkunde
- Facharztzentrum Eppendorf
- Universitaetsklinikum Hamburg Eppendorf, Zentrum fuer Radiologie und Endoskopie
- ZytoService Deutschland GmbH, Standort-Hamburg-Jenfeld
- HKS Kardiologische Praxis am Israelitischen Krankenhaus
- Radiologie im Israelitischen Krankenhaus
- Zala Megyei Szent Rafael Korhaz - Onkologiai Osztaly
- Szent Margit Kórház
- Eszak-Pesti Centrumkorhaz-Honvedkorhaz
- Magyar Honvedseg Egeszsegugyi Kozpont
- Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet
- Uzsoki Utcai Korhaz
- Debreceni Egyetem Klinikai Kozpont
- Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar
- Pecsi Tudomanyegyetem Klinikai Kozpont
- Tel Aviv Sourasky Medical Center - Oncology
- The Barzilai Medical Center - Oncology Institute
- Soroka University Medical Center
- MOR Institute
- Ein-Karem Department of Medical Imaging of Hadassah Medical Organization, Hadassah Medical Center,
- Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem
- Pharmacy of Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem
- Mt. Scopus Department of Medical Imaging of Hadassah Medical Organization,
- Imaging Department of Meir Medical Center
- Meir Medical Center
- Pharmacy of Rabin Medical Center, Beilinson Hospital
- Rabin Medical Center, Beilinson Hospital
- The Chaim Sheba Medical Center
- Ospedali Riuniti Umberto I
- ASST Bergamo Ovest, Ospedale Treviglio Caravaggio di Trevigl
- Oculistica, ASST Papa Giovanni XXIII
- Oncologia, ASST Papa Giovanni XXIII
- Clinica di Oncologia Medica AOU di Cagliari Presidio Duilio Casula Monserrato
- Farmacia AOU di Cagliari Presidio Duilio Casula Monserrato
- Radiologia AOU di Cagliari Presidio Duilio Casula Monserrato
- Oculistica - ASST Cremona, Ospedale di Cremona
- SC Farmacia Aziendale - ASST Cremona, Ospedale di Cremona
- SC Oncologia - ASST Cremona, Ospedale di Cremona
- U.O. Oculistica, Istituto Clinico HUMANITAS
- U.O. di Oncologia ed Ematologia, Istituto Clinico HUMANITAS
- IRCCS Ospedale San Raffaele - U.O. di Medicina Oncologica
- Servizio di Farmacia - IRCCS Ospedale San Raffaele
- S.C. Radiologia diagnostica e interventistica - Fondazione IRCCS Istituto Nazionale dei Tumori
- SC Oncologia Medica 1, SS Oncologia Medica Gastroenterologica
- Cardiologia per i pazienti oncologici - Istituto Oncologico Veneto I.R.C.C.S
- Clinica Oculistica - Azienda Ospedaliera di Padova
- U.O. Oncologia Medica 1 - Istituto Oncologico Veneto I.R.C.C.S
- Policlinico S.Orsola Malpighi, AOU di Bologna - Oncologia Medica
- Divisione Anatomia Patologica Presidio San Giovanni di Dio
- Oculistica AOU di Cagliari Presidio San Giovanni di Dio
- Dipartimento Neuromuscoloscheletrico e Organi di Senso, "Oncologia Oculare Unit"
- SC oncologia Medica I - Azienda Ospedaliero Universitaria Careggi
- Radiologia
- Unita di Oncologia Medica Gastrointestinale e Tumori Neuroendocrini
- Grande Ospedale Metropolitano Niguarda
- Dipartimento Interaziendale Farmaceutico - AOU Policlinico di Modena
- SC di Oftalmologia - AOU Policlinico di Modena
- SC di Radiologia, Dipartimento Interaziendale integrato Diagnostica per Immagini
- SSD Day Hospital Oncologico - Dipartimento ad attivita integrata di Oncologia, Ematologia
- AOU Universita degli Studi della Campania L. Vanvitelli - DAI di Medicina Interna e Specialistica
- AOU Universita degli Studi della Campania L. Vanvitelli - U. Ma.Ca.
- AOU Universita degli Studi della Campania L. Vanvitelli
- AOU Universita degli Studi della Campania L. Vanvitelli
- UO Oculistica - AOU Pisana, Stabilimento Ospedaliero di Cisanello
- SOD Radiodiagnostica 3 - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara
- UO Farmaceutica, Gestione del Farmaco - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara
- UO Oncologia Medica 2 - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara
- U.O.S.D. Oncologia Medica, Dipartimento di Medicina - Fondazione PTV Policlinico Tor Vergata
- U.O.S.D. Patologie Retiniche - Fondazione PTV Policlinico Tor Vergata
- Chayagasaka Eye Clinic
- Aichi Cancer Center Hospital
- National Cancer Center Hospital East
- Hokkaido University Hospital
- Kanazawa University Hospital
- St. Marianna University School of Medicine Hospital
- Tsukahara Eye Clinic
- Kanagawa Cancer Center
- Osaka University Hospital Laboratory for Clinical Investigation
- National Cancer Center Hospital
- National Hospital Organization Kyushu Cancer Center
- Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers
- National Hospital Organization Osaka National Hospital
- Seoul National University Bundang Hospital
- Ajou University Hospital
- Hallym University Sacred Heart Hospital
- Chonnam National University Hwasun Hospital
- Korea University Guro Hospital
- Dong-A University Hospital
- Gachon University Gil Medical Center
- Korea University Anam Hospital IRB
- Seoul National University Hospital
- Severance Hospital, Yonsei University Health System
- Asan Medical Center
- Samsung Medical Center
- The Catholic University of Korea, Seoul St. Mary's Hospital
- Superare Centro de Infusion S.A. de C.V.
- Consultorio dentro de la Torre Medica Dalinde (Oncologia Medica)
- Rijnstate Hospital Arnhem
- Rijnstate Hospital Velp
- Maastricht University Medical Center (MUMC)
- The Netherlands Cancer Institute
- Onze Lieve Vrouwen Gasthuis
- Haga Ziekenhuis
- Universitair Medisch Centrum Utrecht
- Universitair Medisch Centrum Utrecht
- Colosseum Øyelegesenter C/O LB Holdings AS
- Colosseum Øyelegesenter C/O LB Holdings AS
- Oslo universitetssykehus, Radiumhospitalet
- Sykehusapoteket Oslo, Radiumhospitalet
- Szpital Specjalistyczny W Brzozowie, Podkarpacki Osrodek Onkologiczny Im.Ks.B.Markiewicza
- Wojewodzki Szpital Zespolony, Oddzial Onkologiczny
- Szpital Specjalistyczny im. L. Rydygiera w Krakowie Sp.z.o.o.
- Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina
- NZOZ Centrum Medyczne HCP
- NZOZ Przychodnia Specjalistyczna GUTMED
- MAGODENT Sp. z o.o. Szpital Elblaska
- Regional Budgetary Healthcare Institution Kursk Regional Clinical
- Evimed Llc
- Federal State Budget Institution "N.N. Blokhin Russian Cancer Research Center" of the
- Federal State Budget Institution "N.N. Blokhin Russian Cancer Research Center"
- A. Tsyb Medical Radiological Research Center - branch of the
- State Budgetary Educational Institution of Higher Professional Education First Saint Petersburg
- Complejo Hospitalario de Jaen
- Sercosa - Clinica de las Nieves
- Hospital Universitario Son Espases
- Institut Catala d'Oncologia
- Hospital Universitari Parc Tauli
- Hospital Universitario Reina Sofía
- Hospital Nuestra Señora del Rosario
- Hospital Universitari Sant Joan de Reus
- Hospital del Mar
- Clinica Corachan
- Hospital Quiron Salud Barcelona
- Cetir Centre Medic S.L.
- Hospital Universitario Vall d'Hebron
- Hospital Universitario de Burgos
- Consulta Dr. Juan Carlos Castillo Dominguez
- Gabinete Radiologico Dr. Pita
- Hospital General Universitario Gregorio Maranon
- Hospital Universitario Ramón y Cajal
- Hospital Clinico San Carlos
- Hospital Universitario Fundacion Jimenez Diaz
- Hospital Universitario 12 de Octubre
- Hospital Universitario La Paz
- Hospital HM Universitario Sanchinarro
- Hospital Universitario Virgen del Rocio
- Clinica Oftalvist
- Fundacion Instituto Valenciano de Oncologia
- Hospital Clinico Universitario de Valencia
- Hospital General Universitario de Valencia
- Hospital Quiron Salud Zaragoza
- Hospital Universitario Miguel Servet
- Changhua Christian Hospital
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- China Medical University Hospital
- National Cheng Kung University Hospital
- National Taiwan University Hospital
- Chang Gung Memorial Hospital, Linkou
- Ege University Medical Faculty
- Izmir Medical Park Hospital - Medical Oncology
- Medeniyet University Goztepe Training and Research Hospital
- Hacettepe University Medical Faculty
- Uludag University Hospital
- Trakya Universitesi Tip Fakultesi
- Inonu Universitesi Turgut Ozal Medical Center
- Oftalmolohycheskyi tsentr "Vzghliad" MTs
- Oftalmolohycheskyi tsentr "Vzghliad" MTs
- Derzhavnyi zaklad, Dnipropetrovska medychna akademiia Ministerstva okhorony zdorovia Ukrainy
- Komumalnyi zaklad, Dnipropetrovska miska bahatoprofilna klinichna likarnia Nº4
- Kyivska klinichna likarnia na zaliznychnomu transporti No3 filii Tsentr okhorony zdorov'ia PAT
- Natsionalnyi medychnyi universytet imeni O.O Bohomltsia, kafedra onkolohii
- Natsionalnyi medychnyi universytet imeni O.O Bohomltsia, kafedra oftalmolohii
- Oleksandrivska klinichna likarnia mista Kyieva
- Kyivskyi miskyi klinichnyi onkotsentr
- Vinnytskyi oblasnyi klinichnyi onkolohichnyi dyspanser, viddilennia khimioterapii
- DVNZ "Uzhhorodskyi natsionalnyi universytet"
- Tsentralna miska klinichna likarnia, Miskyi onkolohichnyi tsentr
- DVNZ "Uzhhorodskyi natsionalnyi universytet"
- TOV "Zakarpatskyi Tsentr Mikrokhirurhii Oka"
- NHS Grampian - Aberdeen Royal Infirmary
- King Edward V11 Hospital
- Beatson West of Scotland Cancer Centre
- University Hospitals Birmingham NHS Foundation Trust Queen Elizabeth Hospital
- Hammersmith Hospital, Imperial College Healthcare NHS Trust
- Imperial College Healthcare NHS Trust, Hammersmith Hospital
- Sarah Cannon Research Institute UK
- Imperial College Healthcare NHS Trust, Charing Cross Hospital
- The Christie NHS Foundation Trust - Christie Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm Type
Experimental
Experimental
Active Comparator
Arm Label
Safety Lead-in, Triplet Arm
Doublet Arm
Control Arm
Arm Description
Encorafenib + binimetinib + cetuximab.
Encorafenib + cetuximab.
Investigator's choice of either irinotecan/cetuximab or FOLFIRI/cetuximab.
Outcomes
Primary Outcome Measures
(Safety Lead-in) Number of Participants With Dose-limiting Toxicities (DLTs)
(Safety Lead-in) Number of Participants With Adverse Events (AEs)
Refer to AE/SAE section for additional data that were measured and analyzed.
(Safety Lead-in) Incidence of Dose Interruptions, Dose Modifications and Discontinuations Due to Adverse Events (AEs)
(Phase 3) Overall Survival (OS) of Triplet Arm vs. Control Arm
(Phase 3) Response Rate (ORR) by Blinded Independent Central Review (BICR) Per Response Evaluation Criteria in Solid Tumors (RECIST), v1.1 of Triplet Arm vs. Control Arm
Secondary Outcome Measures
(Safety Lead-in) Response Rate (ORR) by Investigator
(Safety Lead-in) Response Rate (ORR) by BICR
ORR per RECIST, v1.1, defined as the number of patients achieving an overall best response of CR or partial response (PR) divided by the total number of patients
(Safety Lead-in) Duration of Response (DOR) by Investigator
(Safety Lead-in) Duration of Response (DOR) by BICR
DOR defined as the time from first radiographic evidence of response to the earliest documented disease progression or death due to underlying disease
(Safety Lead-in) Time to Response by Investigator
Time to response defined as the time from first dose to first radiographic evidence of response
(Safety Lead-in) Time to Response by BICR
Time to response defined as the time from first dose to first radiographic evidence of response
(Safety Lead-in) Progression-free Survival (PFS) by Investigator
(Safety Lead-in) Progression-free Survival (PFS) by BICR
PFS defined as the time from first dose to the earliest documented disease progression or death due to any cause
(Phase 3) Overall Survival (OS) in Doublet Arm vs. Control Arm
(Phase 3) Overall Survival (OS) in Triplet Arm vs. Doublet Arm
(Phase 3) Comparison of Progression-free Survival (PFS) in Triplet Arm vs Control Arm Per BICR
(Phase 3) Comparison of Progression-free Survival (PFS) in Triplet Arm vs Control Arm Per Investigator
(Phase 3) Comparison of Progression-free Survival (PFS) in Doublet Arm vs Control Arm Per BICR
(Phase 3) Comparison of Progression-free Survival (PFS) in Doublet Arm vs Control Arm Per Investigator
(Phase 3) Comparison of Progression-free Survival (PFS) in Triplet Arm vs Doublet Arm Per BICR
(Phase 3) Comparison of Progression-free Survival (PFS) in Triplet Arm vs Doublet Arm Per Investigator
Phase 3) Comparison of Objective Response Rate (ORR) in Triplet Arm vs Control Arm Per Investigator
(Phase 3) Comparison of Objective Response Rate (ORR) in Doublet Arm vs Control Arm Per BICR
(Phase 3) Comparison of Objective Response Rate (ORR) in Doublet Arm vs Control Arm Per Investigator
Phase 3) Comparison of Objective Response Rate (ORR) in Triplet Arm vs Doublet Arm Per BICR
Phase 3) Comparison of Objective Response Rate (ORR) in Triplet Arm vs Doublet Arm Per Investigator
(Phase 3) Comparison of Duration of Response (DOR) in Triplet Arm vs Control Arm Per BICR
(Phase 3) Comparison of Duration of Response (DOR) in Triplet Arm vs Control Arm Per Investigator
(Phase 3) Comparison of Duration of Response (DOR) in Doublet Arm vs Control Arm Per BICR
(Phase 3) Comparison of Duration of Response (DOR) in Doublet Arm vs Control Arm Per Investigator
(Phase 3) Comparison of Duration of Response (DOR) in Triplet Arm vs Doublet Arm by BICR
(Phase 3) Comparison of Duration of Response (DOR) in Triplet Arm vs Doublet Arm by Investigator
(Phase 3) Comparison of Time to Response in Triplet Arm vs Control Arm Per BICR
(Phase 3) Comparison of Time to Response in Triplet Arm vs Control Arm Per Investigator
(Phase 3) Comparison of Time to Response in Doublet Arm vs Control Arm Per BICR
(Phase 3) Comparison of Time to Response in Doublet Arm vs Control Arm Per Investigator
(Phase 3) Comparison of Time to Response in Triplet Arm vs Doublet Arm Per BICR
(Phase 3) Comparison of Time to Response in Triplet Arm vs Doublet Arm Per Investigator
(Phase 3) Change From Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire for Cancer Patients (QLQ-C30) Triplet Arm vs Control Arm, Doublet Arm vs Control, and Triplet vs Doublet
The EORTC QLQ-C30 questionnaire consisted of 30 questions generating five functional scores (physical, role, cognitive, emotional, and social); a global health status/global quality of life scale score; three symptom scale scores (fatigue, pain, and nausea and vomiting); and six stand alone one-item scores that capture additional symptoms (dyspnea, appetite loss, sleep disturbance, constipation, and diarrhea) and perceived financial burden. All the scales and single-item scores were linearly transformed so that each score ranged from 0 to 100. A higher score on the global health and functioning subscales is indicative of better functioning.
(Phase 3) Change From Baseline in the Functional Assessment of Cancer Therapy-Colon Cancer (FACT-C) in Triplet Arm vs Control Arm, Doublet Arm vs Control, and Triplet vs Doublet
FACT-C is a well-characterized and commonly used questionnaire that belongs to the Functional Assessment of Chronic Illness Therapy Measurement System (FACIT). The FACT-G (G for general) questionnaire (27 questions) constitutes the core of all subscales and is applicable to all tumor types. The FACT-C questionnaire contains 9 additional questions on symptoms specific to CRC, 2 of which are only answered by patients with ostomy appliances. These 9 CRC-specific questions are categorized as "additional concerns" on the questionnaire and constitute the "colorectal cancer subscale" score. The patient self-reports his/her QoL for the previous 7 days. The overall score is calculated across all items and a higher score reflects better quality of life (QoL). The table summarizes the functional well-being subscale, the individual questions are linearly scaled and combined to form the functional well-being subscale score, which ranges from 0-28 (higher is better QoL).
(Phase 3) Change From Baseline in the EuroQol-5D-5L (EQ-5D-5L) in Triplet Arm vs Control Arm, Doublet Arm vs Control, and Triplet vs Doublet
The EQ-5D-5L contains 1 item for each of 5 dimensions of health-related QoL (i.e., mobility, self-care, usual activities, pain or discomfort and anxiety or depression). Response options for each item varied from having no problems to moderate problems or extreme problems. The EQ-5D-5L (v4.0) is a standardized measure of health utility that provides a single index value for one's health status. The EQ-5D-5L is frequently used for economic evaluations of health care and has been recognized as a valid and reliable instrument for this purpose. The EQ visual analog scale (VAS) is a score that is directly reported by the patient and ranges from 0 to 100 (higher is better quality health).
(Phase 3) Change From Baseline in the Patient Global Impression of Change (PGIC) in Triplet Arm vs Control Arm, Doublet Arm vs Control, and Triplet vs Doublet
The PGIC is a measure of patients' perceptions of change in their symptoms over time that can be used as an anchoring method to determine the minimal clinically important difference for other patient reported outcome (PROs). For this assessment, patients answered the following question: "Since starting treatment, my colorectal cancer symptoms are: (1) very much improved, (2) much improved, (3) minimally improved, (4) no change, (5) minimally worse, (6) much worse or (7) very much worse."
(Safety Lead-in) Evaluation of the Area Under the Concentration-time Curve (AUC) for Cetuximab
(Safety Lead-in) Evaluation of the Area Under the Concentration-time Curve (AUC) for Encorafenib
(Safety Lead-in) Evaluation of the Area Under the Concentration-time Curve (AUC) for Binimetinib
(Safety Lead-in) Evaluation of the Area Under the Concentration-time Curve (AUC) for Metabolite of Binimetinib (AR00426032)
(Safety Lead-in) Evaluation of the Maximum Concentration (Cmax) for Cetuximab
(Safety Lead-in) Evaluation of the Maximum Concentration (Cmax) for Encorafenib
(Safety Lead-in) Evaluation of the Maximum Concentration (Cmax) for Binimetinib
(Safety Lead-in) Evaluation of the Maximum Concentration (Cmax) for Metabolite of Binimetinib (AR00426032)
(Safety Lead-in) Evaluation of the Time of Maximum Observed Concentration (Tmax) for Cetuximab
(Safety Lead-in) Evaluation of the Time of Maximum Observed Concentration (Tmax) for Encorafenib
(Safety Lead-in) Evaluation of the Time of Maximum Observed Concentration (Tmax) for Binimetinib
(Safety Lead-in) Evaluation of the Time of Maximum Observed Concentration (Tmax) for Metabolite of Binimetinib (AR00426032)
(Safety Lead-in) Evaluation of the Steady-state Concentration Measured Just Before the Next Dose of Study Drug (Ctrough) for Binimetinib
(Safety Lead-in) Evaluation of the Steady-state Concentration Measured Just Before the Next Dose of Study Drug (Ctrough) for Encorafenib
(Safety Lead-in) Evaluation of the Steady-state Concentration Measured Just Before the Next Dose of Study Drug (Ctrough) for Cetuximab
(Safety Lead-in) Evaluation of the Steady-state Concentration Measured Just Before the Next Dose of Study Drug (Ctrough) for a Metabolite of Binimetinib
(Phase 3) Evaluation of the Model-Based Oral Clearance (CL/F) for Encorafenib
The cross-arm CL/F value is based on the theta determined from a population PK analysis. Data for this Outcome Measure are not reported here because as per plan, the analysis includes pooled data from participants enrolled in multiple studies including those who were not enrolled in this study. The NCTID for those studies for which results have not yet been posted include: NCT01719380, NCT01543698, and NCT01436656. An additional study ARRAY-162-105 is not required to register.
(Phase 3) Evaluation of the Model-Based Oral Clearance (CL/F) for Binimetinib
The cross-arm CL/F value is based on the theta determined from a population PK analysis. Data for this Outcome Measure are not reported here because as per plan, the analysis includes pooled data from participants enrolled in multiple studies including those who were not enrolled in this study. The NCTID for those studies for which results have not yet been posted include: NCT01719380, NCT01543698, and NCT01436656. An additional study ARRAY-162-105 is not required to register.
(Phase 3) Evaluation of the Model-Based Clearance (CL) for Cetuximab
The cross-arm CL/F value is based on the theta determined from a population PK analysis. Data for this Outcome Measure are not reported here because as per plan, the analysis includes pooled data from participants enrolled in multiple studies including those who were not enrolled in this study. The NCTID for those studies for which results have not yet been posted include: NCT01719380, NCT01543698, and NCT01436656. An additional study ARRAY-162-105 is not required to register.
Full Information
NCT ID
NCT02928224
First Posted
August 16, 2016
Last Updated
May 3, 2023
Sponsor
Pfizer
Collaborators
Merck KGaA, Darmstadt, Germany, Pierre Fabre Medicament, Ono Pharmaceutical Co. Ltd
1. Study Identification
Unique Protocol Identification Number
NCT02928224
Brief Title
Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer
Acronym
BEACON CRC
Official Title
A Multicenter, Randomized, Open-label, 3-Arm Phase 3 Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer
Study Type
Interventional
2. Study Status
Record Verification Date
May 2023
Overall Recruitment Status
Completed
Study Start Date
October 13, 2016 (Actual)
Primary Completion Date
February 11, 2019 (Actual)
Study Completion Date
November 10, 2022 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Pfizer
Collaborators
Merck KGaA, Darmstadt, Germany, Pierre Fabre Medicament, Ono Pharmaceutical Co. Ltd
4. Oversight
Studies a U.S. FDA-regulated Drug Product
Yes
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
This is a multicenter, randomized, open-label, 3-arm Phase 3 study to evaluate encorafenib + cetuximab plus or minus binimetinib versus Investigator's choice of either irinotecan/cetuximab or FOLFIRI/cetuximab, as controls, in patients with BRAFV600E mCRC whose disease has progressed after 1 or 2 prior regimens in the metastatic setting. The study contains a Safety Lead-in Phase in which the safety and tolerability of encorafenib + binimetinib + cetuximab will be assessed prior to the Phase 3 portion of the study.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
BRAF V600E-mutant Metastatic Colorectal Cancer
Keywords
Colorectal cancer, BRAF, BRAFV600E
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Sequential Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
702 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Safety Lead-in, Triplet Arm
Arm Type
Experimental
Arm Description
Encorafenib + binimetinib + cetuximab.
Arm Title
Doublet Arm
Arm Type
Experimental
Arm Description
Encorafenib + cetuximab.
Arm Title
Control Arm
Arm Type
Active Comparator
Arm Description
Investigator's choice of either irinotecan/cetuximab or FOLFIRI/cetuximab.
Intervention Type
Drug
Intervention Name(s)
Encorafenib
Intervention Description
Orally, once daily.
Intervention Type
Drug
Intervention Name(s)
Binimetinib
Intervention Description
Orally, twice daily.
Intervention Type
Drug
Intervention Name(s)
Cetuximab
Intervention Description
Standard of care.
Intervention Type
Drug
Intervention Name(s)
Irinotecan
Intervention Description
Standard of care.
Intervention Type
Drug
Intervention Name(s)
Folinic Acid
Other Intervention Name(s)
FA
Intervention Description
Standard of care.
Intervention Type
Drug
Intervention Name(s)
5-Fluorouracil
Other Intervention Name(s)
5-FU
Intervention Description
Standard of care.
Primary Outcome Measure Information:
Title
(Safety Lead-in) Number of Participants With Dose-limiting Toxicities (DLTs)
Time Frame
Cycle 1 (up to 28 days)
Title
(Safety Lead-in) Number of Participants With Adverse Events (AEs)
Description
Refer to AE/SAE section for additional data that were measured and analyzed.
Time Frame
Duration of safety lead-in, approximately 6 months (up to 28 days per cycle)
Title
(Safety Lead-in) Incidence of Dose Interruptions, Dose Modifications and Discontinuations Due to Adverse Events (AEs)
Time Frame
Duration of safety lead-in, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Overall Survival (OS) of Triplet Arm vs. Control Arm
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Response Rate (ORR) by Blinded Independent Central Review (BICR) Per Response Evaluation Criteria in Solid Tumors (RECIST), v1.1 of Triplet Arm vs. Control Arm
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Secondary Outcome Measure Information:
Title
(Safety Lead-in) Response Rate (ORR) by Investigator
Time Frame
Duration of safety lead-in, approximately 6 months (up to 28 days per cycle)
Title
(Safety Lead-in) Response Rate (ORR) by BICR
Description
ORR per RECIST, v1.1, defined as the number of patients achieving an overall best response of CR or partial response (PR) divided by the total number of patients
Time Frame
Duration of safety lead-in, approximately 6 months (up to 28 days per cycle)
Title
(Safety Lead-in) Duration of Response (DOR) by Investigator
Time Frame
Duration of safety lead-in, approximately 6 months (up to 28 days per cycle)
Title
(Safety Lead-in) Duration of Response (DOR) by BICR
Description
DOR defined as the time from first radiographic evidence of response to the earliest documented disease progression or death due to underlying disease
Time Frame
Duration of safety lead-in, approximately 6 months (up to 28 days per cycle)
Title
(Safety Lead-in) Time to Response by Investigator
Description
Time to response defined as the time from first dose to first radiographic evidence of response
Time Frame
Duration of safety lead-in, approximately 6 months (up to 28 days per cycle)
Title
(Safety Lead-in) Time to Response by BICR
Description
Time to response defined as the time from first dose to first radiographic evidence of response
Time Frame
Duration of safety lead-in, approximately 6 months (up to 28 days per cycle)
Title
(Safety Lead-in) Progression-free Survival (PFS) by Investigator
Time Frame
Duration of safety lead-in, approximately 6 months (up to 28 days per cycle)
Title
(Safety Lead-in) Progression-free Survival (PFS) by BICR
Description
PFS defined as the time from first dose to the earliest documented disease progression or death due to any cause
Time Frame
Duration of safety lead-in, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Overall Survival (OS) in Doublet Arm vs. Control Arm
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Overall Survival (OS) in Triplet Arm vs. Doublet Arm
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Progression-free Survival (PFS) in Triplet Arm vs Control Arm Per BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Progression-free Survival (PFS) in Triplet Arm vs Control Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Progression-free Survival (PFS) in Doublet Arm vs Control Arm Per BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Progression-free Survival (PFS) in Doublet Arm vs Control Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Progression-free Survival (PFS) in Triplet Arm vs Doublet Arm Per BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Progression-free Survival (PFS) in Triplet Arm vs Doublet Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
Phase 3) Comparison of Objective Response Rate (ORR) in Triplet Arm vs Control Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Objective Response Rate (ORR) in Doublet Arm vs Control Arm Per BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Objective Response Rate (ORR) in Doublet Arm vs Control Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
Phase 3) Comparison of Objective Response Rate (ORR) in Triplet Arm vs Doublet Arm Per BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
Phase 3) Comparison of Objective Response Rate (ORR) in Triplet Arm vs Doublet Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Duration of Response (DOR) in Triplet Arm vs Control Arm Per BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Duration of Response (DOR) in Triplet Arm vs Control Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Duration of Response (DOR) in Doublet Arm vs Control Arm Per BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Duration of Response (DOR) in Doublet Arm vs Control Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Duration of Response (DOR) in Triplet Arm vs Doublet Arm by BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Duration of Response (DOR) in Triplet Arm vs Doublet Arm by Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Time to Response in Triplet Arm vs Control Arm Per BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Time to Response in Triplet Arm vs Control Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Time to Response in Doublet Arm vs Control Arm Per BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Time to Response in Doublet Arm vs Control Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Time to Response in Triplet Arm vs Doublet Arm Per BICR
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Comparison of Time to Response in Triplet Arm vs Doublet Arm Per Investigator
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Change From Baseline in the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire for Cancer Patients (QLQ-C30) Triplet Arm vs Control Arm, Doublet Arm vs Control, and Triplet vs Doublet
Description
The EORTC QLQ-C30 questionnaire consisted of 30 questions generating five functional scores (physical, role, cognitive, emotional, and social); a global health status/global quality of life scale score; three symptom scale scores (fatigue, pain, and nausea and vomiting); and six stand alone one-item scores that capture additional symptoms (dyspnea, appetite loss, sleep disturbance, constipation, and diarrhea) and perceived financial burden. All the scales and single-item scores were linearly transformed so that each score ranged from 0 to 100. A higher score on the global health and functioning subscales is indicative of better functioning.
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Change From Baseline in the Functional Assessment of Cancer Therapy-Colon Cancer (FACT-C) in Triplet Arm vs Control Arm, Doublet Arm vs Control, and Triplet vs Doublet
Description
FACT-C is a well-characterized and commonly used questionnaire that belongs to the Functional Assessment of Chronic Illness Therapy Measurement System (FACIT). The FACT-G (G for general) questionnaire (27 questions) constitutes the core of all subscales and is applicable to all tumor types. The FACT-C questionnaire contains 9 additional questions on symptoms specific to CRC, 2 of which are only answered by patients with ostomy appliances. These 9 CRC-specific questions are categorized as "additional concerns" on the questionnaire and constitute the "colorectal cancer subscale" score. The patient self-reports his/her QoL for the previous 7 days. The overall score is calculated across all items and a higher score reflects better quality of life (QoL). The table summarizes the functional well-being subscale, the individual questions are linearly scaled and combined to form the functional well-being subscale score, which ranges from 0-28 (higher is better QoL).
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Change From Baseline in the EuroQol-5D-5L (EQ-5D-5L) in Triplet Arm vs Control Arm, Doublet Arm vs Control, and Triplet vs Doublet
Description
The EQ-5D-5L contains 1 item for each of 5 dimensions of health-related QoL (i.e., mobility, self-care, usual activities, pain or discomfort and anxiety or depression). Response options for each item varied from having no problems to moderate problems or extreme problems. The EQ-5D-5L (v4.0) is a standardized measure of health utility that provides a single index value for one's health status. The EQ-5D-5L is frequently used for economic evaluations of health care and has been recognized as a valid and reliable instrument for this purpose. The EQ visual analog scale (VAS) is a score that is directly reported by the patient and ranges from 0 to 100 (higher is better quality health).
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Phase 3) Change From Baseline in the Patient Global Impression of Change (PGIC) in Triplet Arm vs Control Arm, Doublet Arm vs Control, and Triplet vs Doublet
Description
The PGIC is a measure of patients' perceptions of change in their symptoms over time that can be used as an anchoring method to determine the minimal clinically important difference for other patient reported outcome (PROs). For this assessment, patients answered the following question: "Since starting treatment, my colorectal cancer symptoms are: (1) very much improved, (2) much improved, (3) minimally improved, (4) no change, (5) minimally worse, (6) much worse or (7) very much worse."
Time Frame
Duration of Phase 3, approximately 6 months (up to 28 days per cycle)
Title
(Safety Lead-in) Evaluation of the Area Under the Concentration-time Curve (AUC) for Cetuximab
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Area Under the Concentration-time Curve (AUC) for Encorafenib
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Area Under the Concentration-time Curve (AUC) for Binimetinib
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Area Under the Concentration-time Curve (AUC) for Metabolite of Binimetinib (AR00426032)
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Maximum Concentration (Cmax) for Cetuximab
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Maximum Concentration (Cmax) for Encorafenib
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Maximum Concentration (Cmax) for Binimetinib
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Maximum Concentration (Cmax) for Metabolite of Binimetinib (AR00426032)
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Time of Maximum Observed Concentration (Tmax) for Cetuximab
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Time of Maximum Observed Concentration (Tmax) for Encorafenib
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Time of Maximum Observed Concentration (Tmax) for Binimetinib
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Time of Maximum Observed Concentration (Tmax) for Metabolite of Binimetinib (AR00426032)
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Steady-state Concentration Measured Just Before the Next Dose of Study Drug (Ctrough) for Binimetinib
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Steady-state Concentration Measured Just Before the Next Dose of Study Drug (Ctrough) for Encorafenib
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Steady-state Concentration Measured Just Before the Next Dose of Study Drug (Ctrough) for Cetuximab
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Safety Lead-in) Evaluation of the Steady-state Concentration Measured Just Before the Next Dose of Study Drug (Ctrough) for a Metabolite of Binimetinib
Time Frame
Predose and 1, 2, 4 and 6 hours post-dose on Day 1 of Cycles 1 and 2
Title
(Phase 3) Evaluation of the Model-Based Oral Clearance (CL/F) for Encorafenib
Description
The cross-arm CL/F value is based on the theta determined from a population PK analysis. Data for this Outcome Measure are not reported here because as per plan, the analysis includes pooled data from participants enrolled in multiple studies including those who were not enrolled in this study. The NCTID for those studies for which results have not yet been posted include: NCT01719380, NCT01543698, and NCT01436656. An additional study ARRAY-162-105 is not required to register.
Time Frame
2 and 6 hours post-dose on Day 1 of Cycle 1. Predose and 2 hours post-dose on Day 1 of Cycle 2.
Title
(Phase 3) Evaluation of the Model-Based Oral Clearance (CL/F) for Binimetinib
Description
The cross-arm CL/F value is based on the theta determined from a population PK analysis. Data for this Outcome Measure are not reported here because as per plan, the analysis includes pooled data from participants enrolled in multiple studies including those who were not enrolled in this study. The NCTID for those studies for which results have not yet been posted include: NCT01719380, NCT01543698, and NCT01436656. An additional study ARRAY-162-105 is not required to register.
Time Frame
2 and 6 hours post-dose on Day 1 of Cycle 1. Predose and 2 hours post-dose on Day 1 of Cycle 2.
Title
(Phase 3) Evaluation of the Model-Based Clearance (CL) for Cetuximab
Description
The cross-arm CL/F value is based on the theta determined from a population PK analysis. Data for this Outcome Measure are not reported here because as per plan, the analysis includes pooled data from participants enrolled in multiple studies including those who were not enrolled in this study. The NCTID for those studies for which results have not yet been posted include: NCT01719380, NCT01543698, and NCT01436656. An additional study ARRAY-162-105 is not required to register.
Time Frame
2 and 6 hours post-dose on Day 1 of Cycle 1. Predose and 2 hours post-dose on Day 1 of Cycle 2.
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Key Inclusion Criteria:
Age ≥ 18 years at time of informed consent
Histologically- or cytologically-confirmed CRC that is metastatic
Presence of BRAFV600E in tumor tissue as previously determined by a local assay at any time prior to Screening or by the central laboratory
Progression of disease after 1 or 2 prior regimens in the metastatic setting
Evidence of measurable or evaluable non-measurable disease per RECIST, v1.1
Adequate bone marrow, cardiac, kidney and liver function
Able to take oral medications
Female patients are either postmenopausal for at least 1 year, are surgically sterile for at least 6 weeks, or must agree to take appropriate precautions to avoid pregnancy from screening through follow-up if of childbearing potential
Males must agree to take appropriate precautions to avoid fathering a child from screening through follow-up
Key Exclusion Criteria:
Prior treatment with any RAF inhibitor, MEK inhibitor, cetuximab, panitumumab or other epidermal growth factor receptor (EGFR) inhibitors
Prior irinotecan hypersensitivity or toxicity that would suggest an inability to tolerate irinotecan 180 mg/m2 every 2 weeks
Symptomatic brain metastasis or leptomeningeal disease
History or current evidence of retinal vein occlusion or current risk factors for retinal vein occlusion (e.g., uncontrolled glaucoma or ocular hypertension, history of hyperviscosity or hypercoagulability syndromes)
Known history of acute or chronic pancreatitis
History of chronic inflammatory bowel disease or Crohn's disease requiring medical intervention (immunomodulatory or immunosuppressive medications or surgery) ≤12 months prior to randomization
Uncontrolled blood pressure despite medical treatment
Impaired GI function or disease that may significantly alter the absorption of encorafenib or binimetinib (e.g., ulcerative diseases, uncontrolled vomiting, malabsorption syndrome, small bowel resection with decreased intestinal absorption)
Concurrent or previous other malignancy within 5 years of study entry, except cured basal or squamous cell skin cancer, superficial bladder cancer, prostate intraepithelial neoplasm, carcinoma in-situ of the cervix, or other noninvasive or indolent malignancy
History of thromboembolic or cerebrovascular events ≤ 6 months prior to starting study treatment, including transient ischemic attacks, cerebrovascular accidents, deep vein thrombosis or pulmonary emboli
Concurrent neuromuscular disorder that is associated with the potential of elevated creatine (phosphor)kinase (CK) (e.g., inflammatory myopathies, muscular dystrophy, amyotrophic lateral sclerosis, spinal muscular atrophy)
Residual common terminology criteria for adverse events (CTCAE) ≥ Grade 2 toxicity from any prior anticancer therapy, with the exception of Grade 2 alopecia or Grade 2 neuropathy
Known history of HIV infection
Active hepatitis B or hepatitis C infection
Known history of Gilbert's syndrome
Known contraindication to receive cetuximab or irinotecan at the planned doses
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Pfizer CT.gov Call Center
Organizational Affiliation
Pfizer
Official's Role
Study Director
Facility Information:
Facility Name
Mayo Clinic Hospital
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85054
Country
United States
Facility Name
Mayo Clinic
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85054
Country
United States
Facility Name
Mayo Clinic
City
Scottsdale
State/Province
Arizona
ZIP/Postal Code
85259
Country
United States
Facility Name
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
City
Duarte
State/Province
California
ZIP/Postal Code
91010
Country
United States
Facility Name
Compassionate Care Research Group, Inc. at Compassionate Cancer Care Medical Group, Inc.
City
Fountain Valley
State/Province
California
ZIP/Postal Code
92708
Country
United States
Facility Name
Keck Hospital of USC - Norris Healthcare Center (HC3)
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Keck Hospital of USC
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
LAC+USC Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Norris Healthcare Center 3 (HC3)
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
USC Eye Institute
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
USC/Norris Comprehensive Cancer Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90033
Country
United States
Facility Name
Hoag Memorial Hospital Presbyterian
City
Newport Beach
State/Province
California
ZIP/Postal Code
92663
Country
United States
Facility Name
Harvard Eye Associates
City
Orange
State/Province
California
ZIP/Postal Code
92868
Country
United States
Facility Name
Rocky Mountain Lions Eye Institute
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
University of Colorado Cancer Center - Anschutz Cancer Pavilion
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
University of Colorado Denver CTO (CTRC)
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP)
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
University of Colorado Hospital Inpatient Pavillion'
City
Aurora
State/Province
Colorado
ZIP/Postal Code
80045
Country
United States
Facility Name
Smilow Cancer Hospital at Yale - New Haven
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06510
Country
United States
Facility Name
Temple Medical Center
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06510
Country
United States
Facility Name
Yale University, Yale Cancer Center
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06520
Country
United States
Facility Name
Smilow Cancer Hospital Care Center at North Haven
City
North Haven
State/Province
Connecticut
ZIP/Postal Code
06473
Country
United States
Facility Name
The Lennar Foundation Medical Center
City
Coral Gables
State/Province
Florida
ZIP/Postal Code
33146
Country
United States
Facility Name
Broward Health Medical Center
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33316
Country
United States
Facility Name
Dr. Clayton Berger (opthalmology)
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33316
Country
United States
Facility Name
Mehmet F. Hepgur, MD - Broward Health Medical Center
City
Fort Lauderdale
State/Province
Florida
ZIP/Postal Code
33316
Country
United States
Facility Name
Mayo Clinic Florida
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32224
Country
United States
Facility Name
Sylvester Comprehensive Cancer Center/UMHC
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Sylvester at Kendall
City
Miami
State/Province
Florida
ZIP/Postal Code
33176
Country
United States
Facility Name
Illinois CancerCare- Bloomington
City
Bloomington
State/Province
Illinois
ZIP/Postal Code
61704
Country
United States
Facility Name
University of Chicago Medical Center
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60637
Country
United States
Facility Name
Illinois CancerCare- Galesburg
City
Galesburg
State/Province
Illinois
ZIP/Postal Code
61401
Country
United States
Facility Name
University of Chicago Comprehensive Cancer Center at Silver Cross Hospital
City
New Lenox
State/Province
Illinois
ZIP/Postal Code
60451
Country
United States
Facility Name
The University of Chicago Medicine Center for Advanced Care Orland Park
City
Orland Park
State/Province
Illinois
ZIP/Postal Code
60462
Country
United States
Facility Name
Illinois CancerCare- Ottawa
City
Ottawa
State/Province
Illinois
ZIP/Postal Code
61350
Country
United States
Facility Name
Illinois Cancer Care, PC
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61615
Country
United States
Facility Name
Illinois Eye Center
City
Peoria
State/Province
Illinois
ZIP/Postal Code
61615
Country
United States
Facility Name
Carle Cancer Center
City
Urbana
State/Province
Illinois
ZIP/Postal Code
61801
Country
United States
Facility Name
Indiana University Health Hospital
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
Indiana University Health Melvin and Bren Simon Cancer Center
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
Investigational Drug Services IUHSCC
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
Sidney &Lois Eskenazi Hospital
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46202
Country
United States
Facility Name
IU Health Springmill
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46290
Country
United States
Facility Name
Baptist Health Floyd Cancer Center
City
New Albany
State/Province
Indiana
ZIP/Postal Code
47150
Country
United States
Facility Name
University of Iowa Hospitals and Clinics
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
The University of Kansas Clinical Research Center
City
Fairway
State/Province
Kansas
ZIP/Postal Code
66205
Country
United States
Facility Name
The University of Kansas Hospital
City
Kansas City
State/Province
Kansas
ZIP/Postal Code
66160
Country
United States
Facility Name
KU Eye
City
Prairie Village
State/Province
Kansas
ZIP/Postal Code
66208
Country
United States
Facility Name
The University of Kansas Cancer Center and Medical Pavilion
City
Westwood
State/Province
Kansas
ZIP/Postal Code
66205
Country
United States
Facility Name
The University of Kansas Cancer Center, Investigational Drug Services
City
Westwood
State/Province
Kansas
ZIP/Postal Code
66205
Country
United States
Facility Name
Ochsner Clinic Foundation
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70121
Country
United States
Facility Name
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21287
Country
United States
Facility Name
The Investigational Drug Pharmacy (IDS) in the Sidney Kimmel Cancer Center at Johns Hopkins
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21287
Country
United States
Facility Name
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21287
Country
United States
Facility Name
Massachusetts General Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
Ophthalmic Consultants of Boston Inc
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
Brigham & Women's Hospital
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02115
Country
United States
Facility Name
Dana-Farber Cancer Institute (DFCI)
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Dana-Farber Cancer Institute
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02215
Country
United States
Facility Name
Mayo Clinic
City
Rochester
State/Province
Minnesota
ZIP/Postal Code
55905
Country
United States
Facility Name
Siteman Cancer Center - West County
City
Creve Coeur
State/Province
Missouri
ZIP/Postal Code
63141
Country
United States
Facility Name
SSM Health Saint Louis University Hospital
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63104
Country
United States
Facility Name
Barnes Jewish Hospital
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Saint Louis University
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
SSM Health Saint Louis University Hospital
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Washington University Infusion Center Pharmacy
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Washington University School of Medicine
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Siteman Cancer Center - South County
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63129
Country
United States
Facility Name
Siteman Cancer Center - St Peters
City
Saint Peters
State/Province
Missouri
ZIP/Postal Code
63376
Country
United States
Facility Name
Memorial Sloan Kettering: Basking Ridge
City
Basking Ridge
State/Province
New Jersey
ZIP/Postal Code
07920
Country
United States
Facility Name
Memorial Sloan Kettering: Commack
City
Commack
State/Province
New York
ZIP/Postal Code
11725
Country
United States
Facility Name
Memorial Sloan Kettering Cancer Center
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Facility Name
Memorial Sloan Kettering: Rockefeller Outpatient Pavilion
City
New York
State/Province
New York
ZIP/Postal Code
10065
Country
United States
Facility Name
Gabrail Cancer Center Research
City
Canton
State/Province
Ohio
ZIP/Postal Code
44718
Country
United States
Facility Name
Cleveland Clinic Taussig Cancer Institute
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44195
Country
United States
Facility Name
Casey Eye Institute-South Waterfront
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
OHSU Center for Health and Healing
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
OHSU Research Pharmacy Services
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Oregon Health and Science University
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Henry-Joyce Cancer Clinic
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Facility Name
Vanderbilt Eye Institute
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232
Country
United States
Facility Name
The University of Texas MD Anderson Cancer Center
City
Houston
State/Province
Texas
ZIP/Postal Code
77030-4009
Country
United States
Facility Name
Scott & White Clinic - Temple Pavilion
City
Temple
State/Province
Texas
ZIP/Postal Code
76504
Country
United States
Facility Name
Scott & White Medical Center - Temple
City
Temple
State/Province
Texas
ZIP/Postal Code
76508
Country
United States
Facility Name
Medical Oncology Associates, PS DBA Summit Cancer Centers
City
Spokane Valley
State/Province
Washington
ZIP/Postal Code
99216
Country
United States
Facility Name
Spokane Eye Clinic
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
Facility Name
Inland Imaging, LLC Holy Family Hospital
City
Spokane
State/Province
Washington
ZIP/Postal Code
99208
Country
United States
Facility Name
Medical Oncology Associates, PS DBA Summit Cancer Centers
City
Spokane
State/Province
Washington
ZIP/Postal Code
99208
Country
United States
Facility Name
Providence Holy Family Nuclear Medicine
City
Spokane
State/Province
Washington
ZIP/Postal Code
99208
Country
United States
Facility Name
University of Wisconsin Clinical Science Center
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53792
Country
United States
Facility Name
CLINICA PERGAMINO S.A. (Centro de Investigacion Pergamino S.A.)
City
Pergamino
State/Province
Buenos Aires
ZIP/Postal Code
2700
Country
Argentina
Facility Name
Centro Medico INFINITO
City
Santa Rosa
State/Province
LA Pampa
ZIP/Postal Code
L6300EAN
Country
Argentina
Facility Name
Centro Medico CAIPO (Centro para la Atención del paciente Oncológico)
City
San Miguel de Tucumán
State/Province
Tucumán
ZIP/Postal Code
T4000GTB
Country
Argentina
Facility Name
Clinica Universitaria Reina Fabiola
City
Cordoba
ZIP/Postal Code
X5004FHP
Country
Argentina
Facility Name
Centro Oncologico Riojano Integral - CORI
City
La Rioja
ZIP/Postal Code
5300
Country
Argentina
Facility Name
St Vincent's Clinic
City
Darlinghurst
State/Province
NEW South Wales (nsw)
ZIP/Postal Code
2010
Country
Australia
Facility Name
St Vincent's Hospital Sydney
City
Darlinghurst
State/Province
NEW South Wales (nsw)
ZIP/Postal Code
2010
Country
Australia
Facility Name
Marsden Eye Specialists
City
Parramatta
State/Province
NEW South Wales (nsw)
ZIP/Postal Code
2150
Country
Australia
Facility Name
Newcastle Eye Centre
City
Sydney
State/Province
NEW South Wales (nsw)
ZIP/Postal Code
2300
Country
Australia
Facility Name
Mater Misericordiae Limited
City
South Brisbane
State/Province
Queensland
ZIP/Postal Code
4101
Country
Australia
Facility Name
Central Adelaide Local Health Network Inc. operating as Royal Adelaide Hospital
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Flinders Medical Centre
City
Bedford Park
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
Facility Name
Central Adelaide Local Health Network Inc. operating as The Queen Elizabeth Hospital
City
Woodville South
State/Province
South Australia
ZIP/Postal Code
5011
Country
Australia
Facility Name
Monash Health Translation Precinct - Monash Health
City
Clayton
State/Province
Victoria
ZIP/Postal Code
3168
Country
Australia
Facility Name
Austin Health
City
Heidelberg
State/Province
Victoria
ZIP/Postal Code
3084
Country
Australia
Facility Name
Peter MacCallum Cancer Centre
City
Melbourne
State/Province
Victoria
ZIP/Postal Code
3000
Country
Australia
Facility Name
Klinikum Wels - Grieskirchen GmbH, Abteilung fuer Innere Medizin IV
City
Wels
State/Province
Oberoesterreich
ZIP/Postal Code
4600
Country
Austria
Facility Name
Klinikum Wels-Grieskirchen GmbH, Abteilung fuer Augenheilkunde und Optometrie
City
Wels
State/Province
Oberoesterreich
ZIP/Postal Code
4600
Country
Austria
Facility Name
Klinikum Wels-Grieskirchen GmbH, Abteilung fuer Innere Medizin II
City
Wels
State/Province
Oberoesterreich
ZIP/Postal Code
4600
Country
Austria
Facility Name
Klinikum Wels-Grieskirchen GmbH, Institut fuer Nuklearmedizin
City
Wels
State/Province
Oberoesterreich
ZIP/Postal Code
4600
Country
Austria
Facility Name
Klinikum Wels-Grieskirchen GmbH, Institut fuer Radiologie I
City
Wels
State/Province
Oberoesterreich
ZIP/Postal Code
4600
Country
Austria
Facility Name
DZU, Diagnose Zentrum Urania GmbH
City
Wien
ZIP/Postal Code
1010
Country
Austria
Facility Name
AKH Wien
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Medizinische Universitaet Wien/AKH Wien
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Medizinische Universität Wien/AKH Wien
City
Wien
ZIP/Postal Code
1090
Country
Austria
Facility Name
Centre Hospitalier de l'Ardenne - Site de Libramont
City
Libramont-Chevigny
State/Province
Luxembourg
ZIP/Postal Code
6800
Country
Belgium
Facility Name
AZ Sint-Jan Brugge - Oostende AV - Campus Sint-Jan - Oncology
City
Brugge
State/Province
WEST Vlaanderen
ZIP/Postal Code
8000
Country
Belgium
Facility Name
Imelda Ziekenhuis
City
Bonheiden
ZIP/Postal Code
2820
Country
Belgium
Facility Name
Grand Hopital de Charleroi (GHdC)
City
Charleroi
ZIP/Postal Code
6000
Country
Belgium
Facility Name
UZ Antwerpen
City
Edegem
ZIP/Postal Code
2650
Country
Belgium
Facility Name
AZ Maria Middelares
City
Gent
ZIP/Postal Code
9000
Country
Belgium
Facility Name
University Hospital Gasthuisberg (UZ Leuven)
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
Centre Hospitalier Universitaire (CHU) de Liege
City
Liege
ZIP/Postal Code
4000
Country
Belgium
Facility Name
CHC Saint Joseph
City
Liege
ZIP/Postal Code
4000
Country
Belgium
Facility Name
AZ Delta Roeselaere-Menen
City
Roeselaere
ZIP/Postal Code
8800
Country
Belgium
Facility Name
Centre Hospitalier Regional (CHR) - Verviers
City
Verviers
ZIP/Postal Code
4800
Country
Belgium
Facility Name
Hospital do Olho
City
Salvador
State/Province
Bahia
ZIP/Postal Code
41820-020
Country
Brazil
Facility Name
CENOB - Centro de Oncologia da Bahia SS Ltda / Oncovida
City
Salvador
State/Province
Bahia
ZIP/Postal Code
41820-021
Country
Brazil
Facility Name
CEMES Centro Medico Especializado em Oftalmologia
City
Cachoeiro de Itapemirim
State/Province
ES
ZIP/Postal Code
29300-045
Country
Brazil
Facility Name
Centro de Pesquisas Clínicas em Oncologia
City
Cachoeiro de Itapemirim
State/Province
ES
ZIP/Postal Code
29308-014
Country
Brazil
Facility Name
Hospital Evangelico de Cachoeiro de Itapemirim
City
Cachoeiro de Itapemirim
State/Province
ES
ZIP/Postal Code
29308-055
Country
Brazil
Facility Name
Instituto Vizibelli
City
Belo Horizonte
State/Province
Minas Gerais
ZIP/Postal Code
30110-921
Country
Brazil
Facility Name
CENANTRON - Centro Avancado de Tratamento Oncologic
City
Belo Horizonte
State/Province
Minas Gerais
ZIP/Postal Code
30130-090
Country
Brazil
Facility Name
Fundação Universidade de Caxias do Sul
City
Caxias do Sul
State/Province
RS
ZIP/Postal Code
95070-560
Country
Brazil
Facility Name
Daniel Lubisco Pandolfi
City
Lajeado
State/Province
RS
ZIP/Postal Code
95900-000
Country
Brazil
Facility Name
Sociedade Beneficencia e Cardade de Lajeado/Hospital Bruno Born
City
Lajeado
State/Province
RS
ZIP/Postal Code
95900-000
Country
Brazil
Facility Name
Sociedade Beneficencia e Cardade de Lajeado/Hospital Bruno Born
City
Lajeado
State/Province
RS
ZIP/Postal Code
95900-010
Country
Brazil
Facility Name
Associacao Hospitalar Beneficente Sao Vicente de Paulo / Hospital Sao Vicente de Paulo
City
Passo Fundo
State/Province
RS
ZIP/Postal Code
99010-080
Country
Brazil
Facility Name
Consultorio Medico de Oftalmologia - Dr. Ricardo Tres
City
Passo Fundo
State/Province
RS
ZIP/Postal Code
99010-080
Country
Brazil
Facility Name
Hospital Sao Vicente de Paulo
City
Passo Fundo
State/Province
RS
ZIP/Postal Code
99010-090
Country
Brazil
Facility Name
Thiago Vernetti Ferreira
City
Pelotas
State/Province
RS
ZIP/Postal Code
96010-140
Country
Brazil
Facility Name
Leandro Becker
City
Pelotas
State/Province
RS
ZIP/Postal Code
96015-280
Country
Brazil
Facility Name
Fernanda Mendes
City
Pelotas
State/Province
RS
ZIP/Postal Code
96020-080
Country
Brazil
Facility Name
UPCO - Unidade de Pesquisas Clinicas em Oncologia
City
Pelotas
State/Province
RS
ZIP/Postal Code
96020-080
Country
Brazil
Facility Name
Fernanda Lauermann
City
Pelotas
State/Province
RS
ZIP/Postal Code
96020-260
Country
Brazil
Facility Name
Diogo Duarte Torre
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90020-013
Country
Brazil
Facility Name
Farmacia Central da Irmandade da Santa Casa de Misericordia de Porto Alegre
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90020-090
Country
Brazil
Facility Name
Irmandade da Santa Casa de Misericordia de Porto Alegre
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90020-090
Country
Brazil
Facility Name
Nucleo de Novos Tratamentos em Cancer
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90050-170
Country
Brazil
Facility Name
Centro de Pesquisa Clínica de Oncologia e Hematologia - Hospital Mãe de Deus/AESC
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90110-270
Country
Brazil
Facility Name
Clinica de Oftalmologia Lavinsky
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90470-340
Country
Brazil
Facility Name
Hospital Mãe de Deus
City
Porto Alegre
State/Province
RS
ZIP/Postal Code
90880-480
Country
Brazil
Facility Name
Clinica Toller
City
Barretos
State/Province
SAO Paulo
ZIP/Postal Code
14780-110
Country
Brazil
Facility Name
Olhos Centro Diagnostico e Laser LTDA
City
Barretos
State/Province
SAO Paulo
ZIP/Postal Code
14780-300
Country
Brazil
Facility Name
Fundacao Pio XII
City
Barretos
State/Province
SAO Paulo
ZIP/Postal Code
14784-400
Country
Brazil
Facility Name
Giuliano Santos Borges - ME / Clinica de Neoplasias Litoral - Centro de Novos Tratamentos Itajai
City
Itajai
State/Province
SC
ZIP/Postal Code
88301-220
Country
Brazil
Facility Name
FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC
City
Santo Andre
State/Province
SP
ZIP/Postal Code
09060-650
Country
Brazil
Facility Name
FUNDAÇÃO DO ABC - Faculdade de Medicina do ABC
City
Santo Andre
State/Province
SP
ZIP/Postal Code
09060-870
Country
Brazil
Facility Name
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto
City
Sao Jose do Rio Preto
State/Province
SP
ZIP/Postal Code
15090-000
Country
Brazil
Facility Name
CEPOS - Centro de Estudos e Pesquisas Oncologicas de Sorocaba
City
Sorocaba
State/Province
SP
ZIP/Postal Code
18030-075
Country
Brazil
Facility Name
Instituto de Oncologia de Sorocaba "Dr. Gilson Delgado"
City
Sorocaba
State/Province
SP
ZIP/Postal Code
18030-200
Country
Brazil
Facility Name
Karen Miyuki Kubokawa Shorer
City
Sorocaba
State/Province
SP
ZIP/Postal Code
18040-425
Country
Brazil
Facility Name
Oftalmologia Diagnostica de Sorocaba (ODS)
City
Sorocaba
State/Province
SP
ZIP/Postal Code
18047-620
Country
Brazil
Facility Name
Instituto de Ensino e Pesquisa São Lucas
City
São Paulo
ZIP/Postal Code
01236-030
Country
Brazil
Facility Name
Instituto de Ensino e Pesquisa São Lucas - Pharmacy
City
São Paulo
ZIP/Postal Code
01242-020
Country
Brazil
Facility Name
Hospital Leforte
City
São Paulo
ZIP/Postal Code
01507-000
Country
Brazil
Facility Name
IPEPO - Instituto da Visao
City
São Paulo
ZIP/Postal Code
04038-020
Country
Brazil
Facility Name
Eye Care Centre, Vancouver General Hospital
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 3N9
Country
Canada
Facility Name
BC Cancer, Vancouver Center
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 4E6
Country
Canada
Facility Name
The Ottawa Hospital Cancer Centre
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1H 8L6
Country
Canada
Facility Name
Sunnybrook Research Institute
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M4N 3M5
Country
Canada
Facility Name
Mount Sinai Hospital
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 1X5
Country
Canada
Facility Name
Centre integre universitaire de sante et de services sociaux de l'Ouest-de-l'Ile-de-Montreal
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1M5
Country
Canada
Facility Name
Instituto Clinico Oncologico del Sur (ICOS)
City
Temuco
State/Province
Region DE LA Araucania
ZIP/Postal Code
4810469
Country
Chile
Facility Name
Hospital Clinico Vina Del Mar
City
Vina del Mar
State/Province
V Region Valparaiso
ZIP/Postal Code
2520612
Country
Chile
Facility Name
Ocni ordinace Oftalpro s.r.o.
City
Brno
ZIP/Postal Code
603 00
Country
Czechia
Facility Name
Masarykuv onkologicky ustav
City
Brno
ZIP/Postal Code
656 53
Country
Czechia
Facility Name
Fakultni nemocnice Hradec Kralove
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Fingerlanduv ustav patologie
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
I. interni kardioangiologicka klinika
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Klinika nemoci koznich a pohlavnich
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Nemocnicni lekarna - Usek klinickych studii
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Ocni klinika
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Radiologicka klinika
City
Hradec Kralove
ZIP/Postal Code
500 05
Country
Czechia
Facility Name
Fakultni nemocnice Olomouc, I. interni klinika - kardiologicka
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
Fakultni nemocnice Olomouc, Lekarna
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
Fakultni nemocnice Olomouc
City
Olomouc
ZIP/Postal Code
779 00
Country
Czechia
Facility Name
Odense University Hospital (OUH)
City
Odense C
ZIP/Postal Code
DK-5000
Country
Denmark
Facility Name
Hopital Jean Minjoz
City
Besancon Cedex
ZIP/Postal Code
25030
Country
France
Facility Name
CHU Morvan
City
BREST Cedex
ZIP/Postal Code
29609
Country
France
Facility Name
Centre Ophtalmologique - Pole Vision - Clinique Val d'Ouest
City
Ecully
ZIP/Postal Code
69130
Country
France
Facility Name
Centre Leon Berard
City
Lyon Cedex 08
ZIP/Postal Code
69373
Country
France
Facility Name
ICM Val d'Aurelle
City
Montpellier Cedex 5
ZIP/Postal Code
34298
Country
France
Facility Name
CHU HOTEL-Dieu
City
Nantes Cedex
ZIP/Postal Code
44093
Country
France
Facility Name
Centre hospitalier national d'ophtalmologie des Quinze-Vingts
City
Paris Cedex 12
ZIP/Postal Code
75571
Country
France
Facility Name
Centre Hospitalier National d'Opthalmologie des Quinze-Vingts (CHNO des XV-XX)
City
Paris Cedex 12
ZIP/Postal Code
75571
Country
France
Facility Name
Hopital Georges Pompidou
City
Paris
ZIP/Postal Code
75015
Country
France
Facility Name
CHU Robert Debre
City
Reims Cedex
ZIP/Postal Code
51092
Country
France
Facility Name
SCM Centre d'ophtalmologie
City
Saint Jeand De Vedas
ZIP/Postal Code
34430
Country
France
Facility Name
CHU Toulouse-Institut Inuversitaire du Cancer Toulouse
City
Toulouse Cedex 9
ZIP/Postal Code
31059
Country
France
Facility Name
CHU Toulouse-Rangueil
City
Toulouse Cedex 9
ZIP/Postal Code
31059
Country
France
Facility Name
CHU Toulouse - Purpan, hopital Pierre-Paul Riquet
City
Toulouse
ZIP/Postal Code
31057
Country
France
Facility Name
Gustave Roussy
City
Villejuif Cedex
ZIP/Postal Code
94805
Country
France
Facility Name
Universitaetsklinikum Tuebingen
City
Tuebingen
State/Province
Baden-wuerttemberg
ZIP/Postal Code
72076
Country
Germany
Facility Name
Universitaetsklinikum Ulm
City
Ulm
State/Province
Baden-wuerttemberg
ZIP/Postal Code
89081
Country
Germany
Facility Name
Augenklinik der Universitaet Muenchen
City
Muenchen
State/Province
Bayern
ZIP/Postal Code
80336
Country
Germany
Facility Name
LMU Klinikum der Universitaet Muenchen, Campus Grosshadern
City
Muenchen
State/Province
Bayern
ZIP/Postal Code
81377
Country
Germany
Facility Name
Augenarzt-Gemeinschaftspraxis Dr.med.Andreas Kind & Dr.med. Ute Kariger-Schweigert
City
Falkensee
State/Province
Brandenburg
ZIP/Postal Code
14612
Country
Germany
Facility Name
Medizinische Hochschule Hannover (MHH)
City
Hannover
State/Province
Niedersachsen
ZIP/Postal Code
30625
Country
Germany
Facility Name
Medizinische Hochschule Hannover
City
Hannover
State/Province
Niedersachsen
ZIP/Postal Code
30625
Country
Germany
Facility Name
Kliniken Essen Mitte / Knappschaftskrankenhaus
City
Essen
State/Province
Nordrhein-westfalen
ZIP/Postal Code
35136
Country
Germany
Facility Name
Praxis fuer Augenheilkunde Dr. Edmund Meyer-Schwickerath
City
Essen
State/Province
Nordrhein-westfalen
ZIP/Postal Code
45131
Country
Germany
Facility Name
Kliniken Essen-Mitte
City
Essen
State/Province
Nordrhein-westfalen
ZIP/Postal Code
45136
Country
Germany
Facility Name
Universitaetsklinikum Essen (AoeR), Innere Klinik (Tumorforschung), Westdeutsches Tumorzentrum
City
Essen
State/Province
Nordrhein-westfalen
ZIP/Postal Code
45147
Country
Germany
Facility Name
Universitaetsklinikum Essen; Diagnostischeu. Interventionelle Radiologie u. Neuroradiologie
City
Essen
State/Province
Nordrhein-westfalen
ZIP/Postal Code
45147
Country
Germany
Facility Name
Universitaetsklinikum Essen; Nuklearmedizin
City
Essen
State/Province
Nordrhein-westfalen
ZIP/Postal Code
45147
Country
Germany
Facility Name
Universitaetsklinikum Essen; Zentralapotheke
City
Essen
State/Province
Nordrhein-westfalen
ZIP/Postal Code
45147
Country
Germany
Facility Name
Evang. Krankenhaus Essen - Werden; Klinik fuer Augenheilkunde
City
Essen
State/Province
Nordrhein-westfalen
ZIP/Postal Code
45239
Country
Germany
Facility Name
Kliniken Essen Mitte / Knappschaftskrankenhaus
City
Essen
State/Province
Nordrhein-westfalen
ZIP/Postal Code
45276
Country
Germany
Facility Name
Augentagesklinik Maria-Hilf Krankenhaus
City
Moenchengladbach
State/Province
Nordrhein-westfalen
ZIP/Postal Code
41063
Country
Germany
Facility Name
Kliniken Maria Hilf GmbH - Franziskuskrankenhaus
City
Moenchengladbach
State/Province
Nordrhein-westfalen
ZIP/Postal Code
41063
Country
Germany
Facility Name
Kliniken Maria Hilf GmbH; Klinik fuer Radiologie
City
Moenchengladbach
State/Province
Nordrhein-westfalen
ZIP/Postal Code
41063
Country
Germany
Facility Name
Lukaskrankenhaus Neuss; Zentrale Apotheke
City
Neuss
State/Province
Nordrhein-westfalen
ZIP/Postal Code
41464
Country
Germany
Facility Name
Institut f. Pathologie - Ruhr-Universitaet Bochum, Prof. Dr. med. Andrea Tannapfel
City
Bochum
State/Province
North Rhine Westfalia
ZIP/Postal Code
44789
Country
Germany
Facility Name
Augenarzt Praxis Dr. med. Petra Huelsmann
City
Worms
State/Province
Rheinland-pfalz
ZIP/Postal Code
67547
Country
Germany
Facility Name
Gemeinschaftspraxis fuer Radiologie und Nuklearmedizin, Standort Worms
City
Worms
State/Province
Rheinland-pfalz
ZIP/Postal Code
67547
Country
Germany
Facility Name
Martin Apotheke
City
Worms
State/Province
Rheinland-pfalz
ZIP/Postal Code
67547
Country
Germany
Facility Name
Onkologische Schwerpunktpraxis Worms
City
Worms
State/Province
Rheinland-pfalz
ZIP/Postal Code
67547
Country
Germany
Facility Name
Praxisgemeinschaft Kruse + Hofstaetter
City
Worms
State/Province
Rheinland-pfalz
ZIP/Postal Code
67547
Country
Germany
Facility Name
Evangelisches Waldkrankenhaus Spandau
City
Berlin
ZIP/Postal Code
13589
Country
Germany
Facility Name
Universitaetsklinikum Carl Gustav Carus der Technischen Universitaet Dresden
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
Universitaetsklinikum Hamburg Eppendorf, Klinik fuer Augenheilkunde
City
Hamburg
ZIP/Postal Code
20246
Country
Germany
Facility Name
Facharztzentrum Eppendorf
City
Hamburg
ZIP/Postal Code
20249
Country
Germany
Facility Name
Universitaetsklinikum Hamburg Eppendorf, Zentrum fuer Radiologie und Endoskopie
City
Hamburg
ZIP/Postal Code
20251
Country
Germany
Facility Name
ZytoService Deutschland GmbH, Standort-Hamburg-Jenfeld
City
Hamburg
ZIP/Postal Code
22045
Country
Germany
Facility Name
HKS Kardiologische Praxis am Israelitischen Krankenhaus
City
Hamburg
ZIP/Postal Code
22297
Country
Germany
Facility Name
Radiologie im Israelitischen Krankenhaus
City
Hamburg
ZIP/Postal Code
22297
Country
Germany
Facility Name
Zala Megyei Szent Rafael Korhaz - Onkologiai Osztaly
City
Zalaegerszeg
State/Province
Zala
ZIP/Postal Code
H-8900
Country
Hungary
Facility Name
Szent Margit Kórház
City
Budapest
ZIP/Postal Code
1032
Country
Hungary
Facility Name
Eszak-Pesti Centrumkorhaz-Honvedkorhaz
City
Budapest
ZIP/Postal Code
1062
Country
Hungary
Facility Name
Magyar Honvedseg Egeszsegugyi Kozpont
City
Budapest
ZIP/Postal Code
1062
Country
Hungary
Facility Name
Egyesitett Szent Istvan es Szent Laszlo Korhaz-Rendelointezet
City
Budapest
ZIP/Postal Code
1097
Country
Hungary
Facility Name
Uzsoki Utcai Korhaz
City
Budapest
ZIP/Postal Code
1145
Country
Hungary
Facility Name
Debreceni Egyetem Klinikai Kozpont
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
Pecsi Tudomanyegyetem Altalanos Orvostudomanyi Kar
City
Pecs
ZIP/Postal Code
7624
Country
Hungary
Facility Name
Pecsi Tudomanyegyetem Klinikai Kozpont
City
Pecs
ZIP/Postal Code
7624
Country
Hungary
Facility Name
Tel Aviv Sourasky Medical Center - Oncology
City
Tel-Aviv
State/Province
NAP
ZIP/Postal Code
6423906
Country
Israel
Facility Name
The Barzilai Medical Center - Oncology Institute
City
Ashkelon
ZIP/Postal Code
7830604
Country
Israel
Facility Name
Soroka University Medical Center
City
Be'er-Sheva
ZIP/Postal Code
8410101
Country
Israel
Facility Name
MOR Institute
City
Bnei Brak
ZIP/Postal Code
5126413
Country
Israel
Facility Name
Ein-Karem Department of Medical Imaging of Hadassah Medical Organization, Hadassah Medical Center,
City
Jerusalem
ZIP/Postal Code
9112001
Country
Israel
Facility Name
Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem
City
Jerusalem
ZIP/Postal Code
9112001
Country
Israel
Facility Name
Pharmacy of Hadassah Medical Organization, Hadassah Medical Center, Ein-Karem
City
Jerusalem
ZIP/Postal Code
9112001
Country
Israel
Facility Name
Mt. Scopus Department of Medical Imaging of Hadassah Medical Organization,
City
Jerusalem
ZIP/Postal Code
91240
Country
Israel
Facility Name
Imaging Department of Meir Medical Center
City
Kfar Saba
ZIP/Postal Code
4428164
Country
Israel
Facility Name
Meir Medical Center
City
Kfar Saba
ZIP/Postal Code
4428164
Country
Israel
Facility Name
Pharmacy of Rabin Medical Center, Beilinson Hospital
City
Petah Tikva
ZIP/Postal Code
4941492
Country
Israel
Facility Name
Rabin Medical Center, Beilinson Hospital
City
Petah Tikva
ZIP/Postal Code
4941492
Country
Israel
Facility Name
The Chaim Sheba Medical Center
City
Tel-Hashomer
ZIP/Postal Code
5262100
Country
Israel
Facility Name
Ospedali Riuniti Umberto I
City
Torrette Di Ancona
State/Province
Ancona
ZIP/Postal Code
60020
Country
Italy
Facility Name
ASST Bergamo Ovest, Ospedale Treviglio Caravaggio di Trevigl
City
Treviglio
State/Province
Bergamo
ZIP/Postal Code
24047
Country
Italy
Facility Name
Oculistica, ASST Papa Giovanni XXIII
City
Bergamo
State/Province
BG
ZIP/Postal Code
24127
Country
Italy
Facility Name
Oncologia, ASST Papa Giovanni XXIII
City
Bergamo
State/Province
BG
ZIP/Postal Code
24127
Country
Italy
Facility Name
Clinica di Oncologia Medica AOU di Cagliari Presidio Duilio Casula Monserrato
City
Monserrato
State/Province
Cagliari
ZIP/Postal Code
09042
Country
Italy
Facility Name
Farmacia AOU di Cagliari Presidio Duilio Casula Monserrato
City
Monserrato
State/Province
Cagliari
ZIP/Postal Code
09042
Country
Italy
Facility Name
Radiologia AOU di Cagliari Presidio Duilio Casula Monserrato
City
Monserrato
State/Province
Cagliari
ZIP/Postal Code
09042
Country
Italy
Facility Name
Oculistica - ASST Cremona, Ospedale di Cremona
City
Cremona
State/Province
CR
ZIP/Postal Code
26100
Country
Italy
Facility Name
SC Farmacia Aziendale - ASST Cremona, Ospedale di Cremona
City
Cremona
State/Province
CR
ZIP/Postal Code
26100
Country
Italy
Facility Name
SC Oncologia - ASST Cremona, Ospedale di Cremona
City
Cremona
State/Province
CR
ZIP/Postal Code
26100
Country
Italy
Facility Name
U.O. Oculistica, Istituto Clinico HUMANITAS
City
Rozzano
State/Province
Milano
ZIP/Postal Code
20089
Country
Italy
Facility Name
U.O. di Oncologia ed Ematologia, Istituto Clinico HUMANITAS
City
Rozzano (MI)
State/Province
Milan
ZIP/Postal Code
20089
Country
Italy
Facility Name
IRCCS Ospedale San Raffaele - U.O. di Medicina Oncologica
City
Milano
State/Province
MI
ZIP/Postal Code
20132
Country
Italy
Facility Name
Servizio di Farmacia - IRCCS Ospedale San Raffaele
City
Milano
State/Province
MI
ZIP/Postal Code
20132
Country
Italy
Facility Name
S.C. Radiologia diagnostica e interventistica - Fondazione IRCCS Istituto Nazionale dei Tumori
City
Milano
State/Province
MI
ZIP/Postal Code
20133
Country
Italy
Facility Name
SC Oncologia Medica 1, SS Oncologia Medica Gastroenterologica
City
Milano
State/Province
MI
ZIP/Postal Code
20133
Country
Italy
Facility Name
Cardiologia per i pazienti oncologici - Istituto Oncologico Veneto I.R.C.C.S
City
Padova
State/Province
PD
ZIP/Postal Code
35128
Country
Italy
Facility Name
Clinica Oculistica - Azienda Ospedaliera di Padova
City
Padova
State/Province
PD
ZIP/Postal Code
35128
Country
Italy
Facility Name
U.O. Oncologia Medica 1 - Istituto Oncologico Veneto I.R.C.C.S
City
Padova
State/Province
PD
ZIP/Postal Code
35128
Country
Italy
Facility Name
Policlinico S.Orsola Malpighi, AOU di Bologna - Oncologia Medica
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Facility Name
Divisione Anatomia Patologica Presidio San Giovanni di Dio
City
Cagliari
ZIP/Postal Code
09124
Country
Italy
Facility Name
Oculistica AOU di Cagliari Presidio San Giovanni di Dio
City
Cagliari
ZIP/Postal Code
09124
Country
Italy
Facility Name
Dipartimento Neuromuscoloscheletrico e Organi di Senso, "Oncologia Oculare Unit"
City
Firenze
ZIP/Postal Code
50134
Country
Italy
Facility Name
SC oncologia Medica I - Azienda Ospedaliero Universitaria Careggi
City
Firenze
ZIP/Postal Code
50134
Country
Italy
Facility Name
Radiologia
City
Milano
ZIP/Postal Code
20141
Country
Italy
Facility Name
Unita di Oncologia Medica Gastrointestinale e Tumori Neuroendocrini
City
Milano
ZIP/Postal Code
20141
Country
Italy
Facility Name
Grande Ospedale Metropolitano Niguarda
City
Milano
ZIP/Postal Code
20162
Country
Italy
Facility Name
Dipartimento Interaziendale Farmaceutico - AOU Policlinico di Modena
City
Modena
ZIP/Postal Code
41124
Country
Italy
Facility Name
SC di Oftalmologia - AOU Policlinico di Modena
City
Modena
ZIP/Postal Code
41124
Country
Italy
Facility Name
SC di Radiologia, Dipartimento Interaziendale integrato Diagnostica per Immagini
City
Modena
ZIP/Postal Code
41124
Country
Italy
Facility Name
SSD Day Hospital Oncologico - Dipartimento ad attivita integrata di Oncologia, Ematologia
City
Modena
ZIP/Postal Code
41124
Country
Italy
Facility Name
AOU Universita degli Studi della Campania L. Vanvitelli - DAI di Medicina Interna e Specialistica
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
AOU Universita degli Studi della Campania L. Vanvitelli - U. Ma.Ca.
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
AOU Universita degli Studi della Campania L. Vanvitelli
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
AOU Universita degli Studi della Campania L. Vanvitelli
City
Napoli
ZIP/Postal Code
80138
Country
Italy
Facility Name
UO Oculistica - AOU Pisana, Stabilimento Ospedaliero di Cisanello
City
Pisa
ZIP/Postal Code
56124
Country
Italy
Facility Name
SOD Radiodiagnostica 3 - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Facility Name
UO Farmaceutica, Gestione del Farmaco - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Facility Name
UO Oncologia Medica 2 - AOU Pisana, Stabilimento Ospedaliero di Santa Chiara
City
Pisa
ZIP/Postal Code
56126
Country
Italy
Facility Name
U.O.S.D. Oncologia Medica, Dipartimento di Medicina - Fondazione PTV Policlinico Tor Vergata
City
Roma
ZIP/Postal Code
00133
Country
Italy
Facility Name
U.O.S.D. Patologie Retiniche - Fondazione PTV Policlinico Tor Vergata
City
Roma
ZIP/Postal Code
00133
Country
Italy
Facility Name
Chayagasaka Eye Clinic
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
464-0092
Country
Japan
Facility Name
Aichi Cancer Center Hospital
City
Nagoya
State/Province
Aichi
ZIP/Postal Code
464-8681
Country
Japan
Facility Name
National Cancer Center Hospital East
City
Kashiwa-shi
State/Province
Chiba
ZIP/Postal Code
277-8577
Country
Japan
Facility Name
Hokkaido University Hospital
City
Sapporo
State/Province
Hokkaido
ZIP/Postal Code
060-8648
Country
Japan
Facility Name
Kanazawa University Hospital
City
Kanazawa
State/Province
Ishikawa
ZIP/Postal Code
920-8641
Country
Japan
Facility Name
St. Marianna University School of Medicine Hospital
City
Kawasaki
State/Province
Kanagawa
ZIP/Postal Code
216-8511
Country
Japan
Facility Name
Tsukahara Eye Clinic
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
241-0821
Country
Japan
Facility Name
Kanagawa Cancer Center
City
Yokohama
State/Province
Kanagawa
ZIP/Postal Code
241-8515
Country
Japan
Facility Name
Osaka University Hospital Laboratory for Clinical Investigation
City
Suita
State/Province
Osaka
ZIP/Postal Code
565-0871
Country
Japan
Facility Name
National Cancer Center Hospital
City
Chuo-ku
State/Province
Tokyo
ZIP/Postal Code
104-0045
Country
Japan
Facility Name
National Hospital Organization Kyushu Cancer Center
City
Fukuoka
ZIP/Postal Code
811-1395
Country
Japan
Facility Name
Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers
City
Fukuoka
ZIP/Postal Code
815-8588
Country
Japan
Facility Name
National Hospital Organization Osaka National Hospital
City
Osaka
ZIP/Postal Code
540-0006
Country
Japan
Facility Name
Seoul National University Bundang Hospital
City
Seongnam-si
State/Province
Gyeonggi-do
ZIP/Postal Code
13620
Country
Korea, Republic of
Facility Name
Ajou University Hospital
City
Suwon
State/Province
Gyeonggi-do
ZIP/Postal Code
16499
Country
Korea, Republic of
Facility Name
Hallym University Sacred Heart Hospital
City
Anyang
State/Province
Gyeonggido
ZIP/Postal Code
14068
Country
Korea, Republic of
Facility Name
Chonnam National University Hwasun Hospital
City
Hwasun-gun
State/Province
Jeollanam-do
ZIP/Postal Code
58128
Country
Korea, Republic of
Facility Name
Korea University Guro Hospital
City
Seoul
State/Province
Seoul Teugbyeolsi
ZIP/Postal Code
08308
Country
Korea, Republic of
Facility Name
Dong-A University Hospital
City
Busan
ZIP/Postal Code
49201
Country
Korea, Republic of
Facility Name
Gachon University Gil Medical Center
City
Incheon
ZIP/Postal Code
21565
Country
Korea, Republic of
Facility Name
Korea University Anam Hospital IRB
City
Seoul
ZIP/Postal Code
02841
Country
Korea, Republic of
Facility Name
Seoul National University Hospital
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Facility Name
Severance Hospital, Yonsei University Health System
City
Seoul
ZIP/Postal Code
03722
Country
Korea, Republic of
Facility Name
Asan Medical Center
City
Seoul
ZIP/Postal Code
05505
Country
Korea, Republic of
Facility Name
Samsung Medical Center
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Facility Name
The Catholic University of Korea, Seoul St. Mary's Hospital
City
Seoul
ZIP/Postal Code
06591
Country
Korea, Republic of
Facility Name
Superare Centro de Infusion S.A. de C.V.
City
Delegacion Cuauhtemoc
State/Province
Ciudad DE Mexico
ZIP/Postal Code
06760
Country
Mexico
Facility Name
Consultorio dentro de la Torre Medica Dalinde (Oncologia Medica)
City
Ciudad de Mexico
State/Province
Cuauhtemoc
ZIP/Postal Code
06760
Country
Mexico
Facility Name
Rijnstate Hospital Arnhem
City
Arnhem
State/Province
Gelderland
ZIP/Postal Code
6815 AD
Country
Netherlands
Facility Name
Rijnstate Hospital Velp
City
Velp
State/Province
Gelderland
ZIP/Postal Code
6883 AZ
Country
Netherlands
Facility Name
Maastricht University Medical Center (MUMC)
City
Maastricht
State/Province
Limburg
ZIP/Postal Code
6229HX
Country
Netherlands
Facility Name
The Netherlands Cancer Institute
City
Amsterdam
State/Province
Noord-holland
ZIP/Postal Code
1066 CX
Country
Netherlands
Facility Name
Onze Lieve Vrouwen Gasthuis
City
Amsterdam
State/Province
Noord-holland
ZIP/Postal Code
1091 AC
Country
Netherlands
Facility Name
Haga Ziekenhuis
City
Den Haag
State/Province
Zuid-holland
ZIP/Postal Code
2545 AA
Country
Netherlands
Facility Name
Universitair Medisch Centrum Utrecht
City
Utrecht
ZIP/Postal Code
3584 CX
Country
Netherlands
Facility Name
Universitair Medisch Centrum Utrecht
City
Utrecht
ZIP/Postal Code
3584CX
Country
Netherlands
Facility Name
Colosseum Øyelegesenter C/O LB Holdings AS
City
Lommedalen
ZIP/Postal Code
1350
Country
Norway
Facility Name
Colosseum Øyelegesenter C/O LB Holdings AS
City
Oslo
ZIP/Postal Code
0369
Country
Norway
Facility Name
Oslo universitetssykehus, Radiumhospitalet
City
Oslo
ZIP/Postal Code
0379
Country
Norway
Facility Name
Sykehusapoteket Oslo, Radiumhospitalet
City
Oslo
ZIP/Postal Code
0379
Country
Norway
Facility Name
Szpital Specjalistyczny W Brzozowie, Podkarpacki Osrodek Onkologiczny Im.Ks.B.Markiewicza
City
Brzozow
ZIP/Postal Code
36-200
Country
Poland
Facility Name
Wojewodzki Szpital Zespolony, Oddzial Onkologiczny
City
Elblag
ZIP/Postal Code
82-300
Country
Poland
Facility Name
Szpital Specjalistyczny im. L. Rydygiera w Krakowie Sp.z.o.o.
City
Krakow
ZIP/Postal Code
31-826
Country
Poland
Facility Name
Europejskie Centrum Zdrowia Otwock, Szpital im. F. Chopina
City
Otwock
ZIP/Postal Code
05-400
Country
Poland
Facility Name
NZOZ Centrum Medyczne HCP
City
Poznan
ZIP/Postal Code
61-485
Country
Poland
Facility Name
NZOZ Przychodnia Specjalistyczna GUTMED
City
Poznan
ZIP/Postal Code
61495
Country
Poland
Facility Name
MAGODENT Sp. z o.o. Szpital Elblaska
City
Warszawa
ZIP/Postal Code
01-748
Country
Poland
Facility Name
Regional Budgetary Healthcare Institution Kursk Regional Clinical
City
Kursk
State/Province
Kursk Region
ZIP/Postal Code
305524
Country
Russian Federation
Facility Name
Evimed Llc
City
Chelyabinsk
ZIP/Postal Code
454048
Country
Russian Federation
Facility Name
Federal State Budget Institution "N.N. Blokhin Russian Cancer Research Center" of the
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
Federal State Budget Institution "N.N. Blokhin Russian Cancer Research Center"
City
Moscow
ZIP/Postal Code
115478
Country
Russian Federation
Facility Name
A. Tsyb Medical Radiological Research Center - branch of the
City
Obninsk
ZIP/Postal Code
249036
Country
Russian Federation
Facility Name
State Budgetary Educational Institution of Higher Professional Education First Saint Petersburg
City
Sankt-Petersburg
ZIP/Postal Code
197022
Country
Russian Federation
Facility Name
Complejo Hospitalario de Jaen
City
Jaen
State/Province
Andalucia
ZIP/Postal Code
23007
Country
Spain
Facility Name
Sercosa - Clinica de las Nieves
City
Jaen
State/Province
Andalucia
ZIP/Postal Code
23007
Country
Spain
Facility Name
Hospital Universitario Son Espases
City
Palma de Mallorca
State/Province
Baleares
ZIP/Postal Code
07010
Country
Spain
Facility Name
Institut Catala d'Oncologia
City
L'Hospitalet de Llobregat
State/Province
Barcelona
ZIP/Postal Code
08908
Country
Spain
Facility Name
Hospital Universitari Parc Tauli
City
Sabadell
State/Province
Barcelona
ZIP/Postal Code
08208
Country
Spain
Facility Name
Hospital Universitario Reina Sofía
City
Cordoba
State/Province
Cordona
ZIP/Postal Code
14004
Country
Spain
Facility Name
Hospital Nuestra Señora del Rosario
City
Madrid
State/Province
Madrid, Communidad Delaware
ZIP/Postal Code
28006
Country
Spain
Facility Name
Hospital Universitari Sant Joan de Reus
City
Reus
State/Province
Tarragona
ZIP/Postal Code
43204
Country
Spain
Facility Name
Hospital del Mar
City
Barcelona
ZIP/Postal Code
08003
Country
Spain
Facility Name
Clinica Corachan
City
Barcelona
ZIP/Postal Code
08017
Country
Spain
Facility Name
Hospital Quiron Salud Barcelona
City
Barcelona
ZIP/Postal Code
08023
Country
Spain
Facility Name
Cetir Centre Medic S.L.
City
Barcelona
ZIP/Postal Code
08029
Country
Spain
Facility Name
Hospital Universitario Vall d'Hebron
City
Barcelona
ZIP/Postal Code
08035
Country
Spain
Facility Name
Hospital Universitario de Burgos
City
Burgos
ZIP/Postal Code
09006
Country
Spain
Facility Name
Consulta Dr. Juan Carlos Castillo Dominguez
City
Cordoba
ZIP/Postal Code
14008
Country
Spain
Facility Name
Gabinete Radiologico Dr. Pita
City
Madrid
ZIP/Postal Code
28006
Country
Spain
Facility Name
Hospital General Universitario Gregorio Maranon
City
Madrid
ZIP/Postal Code
28007
Country
Spain
Facility Name
Hospital Universitario Ramón y Cajal
City
Madrid
ZIP/Postal Code
28034
Country
Spain
Facility Name
Hospital Clinico San Carlos
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Hospital Universitario Fundacion Jimenez Diaz
City
Madrid
ZIP/Postal Code
28040
Country
Spain
Facility Name
Hospital Universitario 12 de Octubre
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Hospital Universitario La Paz
City
Madrid
ZIP/Postal Code
28046
Country
Spain
Facility Name
Hospital HM Universitario Sanchinarro
City
Madrid
ZIP/Postal Code
28050
Country
Spain
Facility Name
Hospital Universitario Virgen del Rocio
City
Sevilla
ZIP/Postal Code
41013
Country
Spain
Facility Name
Clinica Oftalvist
City
Valencia
ZIP/Postal Code
46004
Country
Spain
Facility Name
Fundacion Instituto Valenciano de Oncologia
City
Valencia
ZIP/Postal Code
46009
Country
Spain
Facility Name
Hospital Clinico Universitario de Valencia
City
Valencia
ZIP/Postal Code
46010
Country
Spain
Facility Name
Hospital General Universitario de Valencia
City
Valencia
ZIP/Postal Code
46014
Country
Spain
Facility Name
Hospital Quiron Salud Zaragoza
City
Zaragoza
ZIP/Postal Code
50006
Country
Spain
Facility Name
Hospital Universitario Miguel Servet
City
Zaragoza
ZIP/Postal Code
50009
Country
Spain
Facility Name
Changhua Christian Hospital
City
Changhua city
State/Province
Changhua County
ZIP/Postal Code
500
Country
Taiwan
Facility Name
Kaohsiung Medical University Chung-Ho Memorial Hospital
City
Kaohsiung
ZIP/Postal Code
807
Country
Taiwan
Facility Name
China Medical University Hospital
City
Taichung
ZIP/Postal Code
40447
Country
Taiwan
Facility Name
National Cheng Kung University Hospital
City
Tainan
ZIP/Postal Code
704
Country
Taiwan
Facility Name
National Taiwan University Hospital
City
Taipei
ZIP/Postal Code
10002
Country
Taiwan
Facility Name
Chang Gung Memorial Hospital, Linkou
City
Taoyuan city
ZIP/Postal Code
333
Country
Taiwan
Facility Name
Ege University Medical Faculty
City
Izmir
State/Province
Bornova
ZIP/Postal Code
35040
Country
Turkey
Facility Name
Izmir Medical Park Hospital - Medical Oncology
City
Izmir
State/Province
Izmir, Karsiyaka
ZIP/Postal Code
35575
Country
Turkey
Facility Name
Medeniyet University Goztepe Training and Research Hospital
City
Istanbul
State/Province
Kadikoy
ZIP/Postal Code
34722
Country
Turkey
Facility Name
Hacettepe University Medical Faculty
City
Ankara
ZIP/Postal Code
06230
Country
Turkey
Facility Name
Uludag University Hospital
City
Bursa
ZIP/Postal Code
16059
Country
Turkey
Facility Name
Trakya Universitesi Tip Fakultesi
City
Edirne
ZIP/Postal Code
22030
Country
Turkey
Facility Name
Inonu Universitesi Turgut Ozal Medical Center
City
Malatya
ZIP/Postal Code
44280
Country
Turkey
Facility Name
Oftalmolohycheskyi tsentr "Vzghliad" MTs
City
Dnipropetrovsk
State/Province
Dnipropetrovska Oblast'
ZIP/Postal Code
41100
Country
Ukraine
Facility Name
Oftalmolohycheskyi tsentr "Vzghliad" MTs
City
Dnipropetrovsk
State/Province
Dnipropetrovska Oblast'
ZIP/Postal Code
49027
Country
Ukraine
Facility Name
Derzhavnyi zaklad, Dnipropetrovska medychna akademiia Ministerstva okhorony zdorovia Ukrainy
City
Dnipropetrovsk
State/Province
Dnipropetrovska Oblast'
ZIP/Postal Code
49102
Country
Ukraine
Facility Name
Komumalnyi zaklad, Dnipropetrovska miska bahatoprofilna klinichna likarnia Nº4
City
Dnipropetrovsk
State/Province
Dnipropetrovska Oblast'
ZIP/Postal Code
49102
Country
Ukraine
Facility Name
Kyivska klinichna likarnia na zaliznychnomu transporti No3 filii Tsentr okhorony zdorov'ia PAT
City
Kyiv
State/Province
Kyivska Oblast'
ZIP/Postal Code
02096
Country
Ukraine
Facility Name
Natsionalnyi medychnyi universytet imeni O.O Bohomltsia, kafedra onkolohii
City
Kyiv
State/Province
Kyivska Oblast'
ZIP/Postal Code
02096
Country
Ukraine
Facility Name
Natsionalnyi medychnyi universytet imeni O.O Bohomltsia, kafedra oftalmolohii
City
Kyiv
State/Province
Kyivska Oblast
ZIP/Postal Code
01601
Country
Ukraine
Facility Name
Oleksandrivska klinichna likarnia mista Kyieva
City
Kyiv
State/Province
Kyivska Oblast
ZIP/Postal Code
01601
Country
Ukraine
Facility Name
Kyivskyi miskyi klinichnyi onkotsentr
City
Kyiv
State/Province
Kyivska Oblast
ZIP/Postal Code
03115
Country
Ukraine
Facility Name
Vinnytskyi oblasnyi klinichnyi onkolohichnyi dyspanser, viddilennia khimioterapii
City
Vinnytsia
State/Province
Vinnyts'ka Oblast'
ZIP/Postal Code
21029
Country
Ukraine
Facility Name
DVNZ "Uzhhorodskyi natsionalnyi universytet"
City
Uzhgorod
State/Province
Zakarpats'ka Oblast'
ZIP/Postal Code
88000
Country
Ukraine
Facility Name
Tsentralna miska klinichna likarnia, Miskyi onkolohichnyi tsentr
City
Uzhgorod
State/Province
Zakarpats'ka Oblast'
ZIP/Postal Code
88000
Country
Ukraine
Facility Name
DVNZ "Uzhhorodskyi natsionalnyi universytet"
City
Uzhhorod
State/Province
Zakarpatska Oblast
ZIP/Postal Code
88000
Country
Ukraine
Facility Name
TOV "Zakarpatskyi Tsentr Mikrokhirurhii Oka"
City
Uzhhorod
State/Province
Zakarpatska Oblast
ZIP/Postal Code
88000
Country
Ukraine
Facility Name
NHS Grampian - Aberdeen Royal Infirmary
City
Aberdeen
State/Province
Aberdeenshire Scotland
ZIP/Postal Code
AB25 2ZN
Country
United Kingdom
Facility Name
King Edward V11 Hospital
City
Windsor
State/Province
Berkshire
ZIP/Postal Code
SL4 3DP
Country
United Kingdom
Facility Name
Beatson West of Scotland Cancer Centre
City
Glasglow
State/Province
Glasglow City, Scotland
ZIP/Postal Code
G12 0YH
Country
United Kingdom
Facility Name
University Hospitals Birmingham NHS Foundation Trust Queen Elizabeth Hospital
City
Birmingham
State/Province
WEST Midlands
ZIP/Postal Code
B15 2TH
Country
United Kingdom
Facility Name
Hammersmith Hospital, Imperial College Healthcare NHS Trust
City
London
ZIP/Postal Code
W12 0HS
Country
United Kingdom
Facility Name
Imperial College Healthcare NHS Trust, Hammersmith Hospital
City
London
ZIP/Postal Code
W12 0HS
Country
United Kingdom
Facility Name
Sarah Cannon Research Institute UK
City
London
ZIP/Postal Code
W1G 6AD
Country
United Kingdom
Facility Name
Imperial College Healthcare NHS Trust, Charing Cross Hospital
City
London
ZIP/Postal Code
W6 8RF
Country
United Kingdom
Facility Name
The Christie NHS Foundation Trust - Christie Hospital
City
Manchester
ZIP/Postal Code
M20 4BX
Country
United Kingdom
12. IPD Sharing Statement
Plan to Share IPD
Yes
IPD Sharing Plan Description
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
IPD Sharing URL
https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests
Citations:
PubMed Identifier
35654691
Citation
Stintzing S, Seufferlein T, Rose C, Reichenbach F, Luftner D. Encorafenib in Combination With Cetuximab After Systemic Therapy in Patients With BRAFV600E Mutant Metastatic Colorectal Cancer: German Health Technology Assessment-Driven Analyses From the BEACON CRC Study. Clin Colorectal Cancer. 2022 Sep;21(3):244-251. doi: 10.1016/j.clcc.2022.04.002. Epub 2022 May 5.
Results Reference
derived
PubMed Identifier
35653981
Citation
Kopetz S, Grothey A, Van Cutsem E, Yaeger R, Wasan H, Yoshino T, Desai J, Ciardiello F, Loupakis F, Hong YS, Steeghs N, Guren TK, Arkenau HT, Garcia-Alfonso P, Belani A, Zhang X, Tabernero J. Quality of life with encorafenib plus cetuximab with or without binimetinib treatment in patients with BRAF V600E-mutant metastatic colorectal cancer: patient-reported outcomes from BEACON CRC. ESMO Open. 2022 Jun;7(3):100477. doi: 10.1016/j.esmoop.2022.100477. Epub 2022 May 30.
Results Reference
derived
PubMed Identifier
33503393
Citation
Tabernero J, Grothey A, Van Cutsem E, Yaeger R, Wasan H, Yoshino T, Desai J, Ciardiello F, Loupakis F, Hong YS, Steeghs N, Guren TK, Arkenau HT, Garcia-Alfonso P, Elez E, Gollerkeri A, Maharry K, Christy-Bittel J, Kopetz S. Encorafenib Plus Cetuximab as a New Standard of Care for Previously Treated BRAF V600E-Mutant Metastatic Colorectal Cancer: Updated Survival Results and Subgroup Analyses from the BEACON Study. J Clin Oncol. 2021 Feb 1;39(4):273-284. doi: 10.1200/JCO.20.02088.
Results Reference
derived
PubMed Identifier
31566309
Citation
Kopetz S, Grothey A, Yaeger R, Van Cutsem E, Desai J, Yoshino T, Wasan H, Ciardiello F, Loupakis F, Hong YS, Steeghs N, Guren TK, Arkenau HT, Garcia-Alfonso P, Pfeiffer P, Orlov S, Lonardi S, Elez E, Kim TW, Schellens JHM, Guo C, Krishnan A, Dekervel J, Morris V, Calvo Ferrandiz A, Tarpgaard LS, Braun M, Gollerkeri A, Keir C, Maharry K, Pickard M, Christy-Bittel J, Anderson L, Sandor V, Tabernero J. Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Colorectal Cancer. N Engl J Med. 2019 Oct 24;381(17):1632-1643. doi: 10.1056/NEJMoa1908075. Epub 2019 Sep 30.
Results Reference
derived
PubMed Identifier
30892987
Citation
Van Cutsem E, Huijberts S, Grothey A, Yaeger R, Cuyle PJ, Elez E, Fakih M, Montagut C, Peeters M, Yoshino T, Wasan H, Desai J, Ciardiello F, Gollerkeri A, Christy-Bittel J, Maharry K, Sandor V, Schellens JHM, Kopetz S, Tabernero J. Binimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study. J Clin Oncol. 2019 Jun 10;37(17):1460-1469. doi: 10.1200/JCO.18.02459. Epub 2019 Mar 20.
Results Reference
derived
Links:
URL
https://pmiform.com/clinical-trial-info-request?StudyID=ARRAY-818-302
Description
To obtain contact information for a study center near you, click here.
Learn more about this trial
Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer
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