Speed of Processing Training in Patients With Parkinson's Disease and Healthy Older Adults
Parkinson's Disease
About this trial
This is an interventional prevention trial for Parkinson's Disease
Eligibility Criteria
Inclusion Criteria Parkinson's disease Subjects:
- Subjects with a clinical diagnosis of idiopathic Parkinson's disease based on the presence of bradykinesia and one or both of the following: rest tremor and/or rigidity
- On stable medications for at least 4 weeks prior to entering the study and expected to not need any medication changes for the duration of the study
- Age ≥50 at the time of entry into the study
- Age of onset of Parkinson's disease 45 - 85 years old
- Asymmetric onset of PD
- Progressive motor symptoms of PD
- Hoehn and Yahr stages 1-4
- Ability to walk up and down a single stair step
- Access to a computer with internet
Exclusion Criteria Parkinson's disease Subjects:
- Atypical features indicative of a Parkinson's Plus disorder (Progressive Supranuclear Palsy, Multiple Systems Atrophy, Corticobasal Degeneration) including cerebellar signs, supranuclear gaze palsy, apraxia, prominent autonomic failure, or other cortical signs.
- Neuroleptic treatment at time of onset of Parkinsonism
- Active treatment with a neuroleptic at time of study entry
- History of multiple strokes with stepwise progression of Parkinsonism
- History of multiple head injuries
- Inability to walk without assistance, including a cane, wheelchair, or walker
- Cognitive dysfunction that would prevent subject's ability to perform virtual reality simulation, speed of processing training, or complete questionnaire
- Blindness
- Any medical condition that, based on discretion of the PI, would prevent the subject's ability to participate in the study
Inclusion Criteria Control Subjects:
- Age ≥50 at the time of entry into the study
- On stable medications for at least 4 weeks prior to entering the study and expected to not need any medication changes for the duration of the study
- Ability to walk up and down a single stair step
- Access to a computer with internet
Exclusion criteria Control Subjects:
- Parkinson's disease or other neurodegenerative disorder
- Inability to walk without assistance, including a cane, wheelchair, or walker
- Cognitive dysfunction that would prevent subject's ability to perform virtual reality simulation, speed of processing training, or complete questionnaires
- Blindness
- Any medical condition that, based on the discretion of the PI, would prevent the subject's ability to participate in the study
Sites / Locations
- University of Alabama at Birmingham
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Active Comparator
Other
Other
Control Initial Training Group
Control Delayed Training Group
PD Initial Training Group
PD Delayed Training Group
Healthy Controls will receive initial SOPT training and will be compared against controls in the delayed training group and the PD subjects in the initial training group
Healthy Controls will receive delayed SOPT training and will be compared against controls in the initial training group and the PD subjects in the delayed training group
PD subjects will received initial SOPT training and will be compared against PD subjects in the delayed training group and the control subjects in the initial training group
PD subjects will receive delayed SOPT training and will be compared against PD subjects in the initial training group and the control subjects in the delayed training group