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Memory Encoding Strategies for People With Mild Cognitive Impairments

Primary Purpose

Mild Cognitive Impairment, Mild Dementia

Status
Completed
Phase
Not Applicable
Locations
International
Study Type
Interventional
Intervention
Behavioral: perceptual-based memory encoding training
Behavioral: semantic-based memory encoding training
Behavioral: Cognitive stimulation group (control group)
Sponsored by
University of Western Sydney
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Mild Cognitive Impairment

Eligibility Criteria

60 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Selection Criteria:

  • are aged 60 or above;
  • have no previous psychiatric or memory disorder history or other neurological illness;
  • have Mini-mental State Examination score (MMSE) greater than or equal to 21;
  • have Clinical Dementia Rating score (CDR) of 0.5 or 1 indicating very mild and mild dementia;
  • do not show sign of depression with score below 9 out of 30 in the Geriatric Depression Scale;
  • are able to communicate effectively;
  • have family member who can participate in the study; and
  • voluntarily consent to participate in the study.

Sites / Locations

  • Western Sydney University
  • The Hong Kong Polytechnic University

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Experimental

Active Comparator

Arm Label

Behavioral: perceptual-based memory encoding training

Behavioral: Semantic-based memory encoding training

Behavioral : control group

Arm Description

Participants receive perceptual-based memory encoding training

Participants receive semantic-based memory encoding training

Participants receive cognitive stimulation intervention

Outcomes

Primary Outcome Measures

Change in Disability Assessment for Dementia
Change in Disability Assessment for Dementia to assess assistance required in basic daily tasks such as dressing, bathing
Change in Instrumental Activities of Daily Living Scale
Change in Instrumental Activities of Daily Living Scale to assess assistance required in instrumental daily tasks such as laundry, meal preparation

Secondary Outcome Measures

Change in Cognistat
Change in Cognistat to assess general cognitive function
Change in Digit Span Test
Change in Digit Span Test to assess attention and working memory
Change in Consortium to Establish a Registry for Alzheimer's Disease
Change in Consortium to Establish a Registry for Alzheimer's Disease to assess cognitive function in verbal fluency, memory

Full Information

First Posted
September 21, 2016
Last Updated
November 1, 2016
Sponsor
University of Western Sydney
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1. Study Identification

Unique Protocol Identification Number
NCT02953964
Brief Title
Memory Encoding Strategies for People With Mild Cognitive Impairments
Official Title
Perceptual and Semantic Memory Encoding Strategies for People With Mild Cognitive Impairment
Study Type
Interventional

2. Study Status

Record Verification Date
November 2016
Overall Recruitment Status
Completed
Study Start Date
May 2010 (undefined)
Primary Completion Date
October 2015 (Actual)
Study Completion Date
October 2015 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
University of Western Sydney

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The purposes of the study are: To evaluate the effectiveness of a perceptual-based training program in enhancing cognitive and everyday functioning of older adults with mild cognitive impairment and mild dementia To evaluate the effectiveness of a semantic-based training program in enhancing cognitive and everyday functioning of older adults with mild cognitive impairment and mild dementia
Detailed Description
People with dementia experience a cognitive decline that affects their functional performance. It has been identified that encoding is less effective in people with dementia. Rehabilitating at the encoding stage is, therefore, essential. A recent systematic review found that effective interventions needed to include training in individually selected memory encoding strategies. These strategies are classified as either perceptual (visual) or semantic (association) memory encoding strategies. Based on the above literature, the chief investigator (Associate Professor Karen Liu) ran a pilot study on an integrated home and community centre cognitive training programme for 20 elderly people with memory problem using a pre-test and post-test comparison design. Extending on the positive results, the aim of this project was to investigate the effectiveness of perceptual and semantic encoding strategies (and compare with a control intervention). It also aims to promote the understanding of memory loss and dementia and the need for early intervention for family members of the participants.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Mild Cognitive Impairment, Mild Dementia

7. Study Design

Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantOutcomes Assessor
Allocation
Non-Randomized
Enrollment
60 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Behavioral: perceptual-based memory encoding training
Arm Type
Experimental
Arm Description
Participants receive perceptual-based memory encoding training
Arm Title
Behavioral: Semantic-based memory encoding training
Arm Type
Experimental
Arm Description
Participants receive semantic-based memory encoding training
Arm Title
Behavioral : control group
Arm Type
Active Comparator
Arm Description
Participants receive cognitive stimulation intervention
Intervention Type
Other
Intervention Name(s)
Behavioral: perceptual-based memory encoding training
Intervention Description
Participants are trained in the use of perceptual-based memory encoding strategies, inclusive of visual imagery and the method of loci. Visual imagery involves the creation and encoding of mental images, while the method of loci refers to linking these images with specific places to facilitate memory (Simon et al., 2012). Participants are taught to visualise performing each step of a task in a familiar environment, such as in their home (Liu et al., 2009). After participants can correctly visualise the entire task, they then progress to actually performing the task. During the intervention sessions, 2-3 tasks are covered each session, and these tasks become progressively difficult as the weeks progress. The intervention lasts for 10 weeks with one session every week. Each session runs for 90 minutes. A follow-up home training program is run once a week for 30 minutes with the participant and their care-giver.
Intervention Type
Other
Intervention Name(s)
Behavioral: semantic-based memory encoding training
Intervention Description
Participants are asked to encode the steps of a task by forming an association of the steps and sequence. Participants are trained in the use of the chunking association method and honeycomb concept and perform different tasks each week, implementing this encoding strategy (Lim et al., 2012). The chunking association method breaks down information into smaller parts and helps with the encoding and retrieval of information. The honeycomb concept allows the steps to form a story in relation to place, time, characters, problem and solution and the story is verbalised. Participants then complete the task. During the intervention sessions, 2-3 tasks are covered each session, and these tasks become progressively difficult as the weeks progress. The intervention lasts for 10 weeks with one session every week. Each session runs for 90 minutes. A follow-up home training program is run once a week for 30 minutes with the participant and their care-giver.
Intervention Type
Other
Intervention Name(s)
Behavioral: Cognitive stimulation group (control group)
Other Intervention Name(s)
Cognitive stimulation group
Intervention Description
Participants receiving cognitive stimulation intervention. It consists of eight sessions that train participants' visual attention and memory, auditory attention and memory and their application in daily activities. Two sessions are also given which allow for participants to apply the training practically in their daily lives. The intervention lasts for 10 weeks with one session every week. Each session runs for 90 minutes. A follow-up home training program is run once a week for 30 minutes with the participant and their care-giver.
Primary Outcome Measure Information:
Title
Change in Disability Assessment for Dementia
Description
Change in Disability Assessment for Dementia to assess assistance required in basic daily tasks such as dressing, bathing
Time Frame
Within two days before the intervention and within two days after the 10-week intervention
Title
Change in Instrumental Activities of Daily Living Scale
Description
Change in Instrumental Activities of Daily Living Scale to assess assistance required in instrumental daily tasks such as laundry, meal preparation
Time Frame
Within two days before the intervention and within two days after the 10-week intervention
Secondary Outcome Measure Information:
Title
Change in Cognistat
Description
Change in Cognistat to assess general cognitive function
Time Frame
Within two days before the intervention and within two days after the 10-week intervention
Title
Change in Digit Span Test
Description
Change in Digit Span Test to assess attention and working memory
Time Frame
Within two days before the intervention and within two days after the 10-week intervention
Title
Change in Consortium to Establish a Registry for Alzheimer's Disease
Description
Change in Consortium to Establish a Registry for Alzheimer's Disease to assess cognitive function in verbal fluency, memory
Time Frame
Within two days before the intervention and within two days after the 10-week intervention

10. Eligibility

Sex
All
Minimum Age & Unit of Time
60 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Selection Criteria: are aged 60 or above; have no previous psychiatric or memory disorder history or other neurological illness; have Mini-mental State Examination score (MMSE) greater than or equal to 21; have Clinical Dementia Rating score (CDR) of 0.5 or 1 indicating very mild and mild dementia; do not show sign of depression with score below 9 out of 30 in the Geriatric Depression Scale; are able to communicate effectively; have family member who can participate in the study; and voluntarily consent to participate in the study.
Facility Information:
Facility Name
Western Sydney University
City
Penrith
State/Province
New South Wales
ZIP/Postal Code
2751
Country
Australia
Facility Name
The Hong Kong Polytechnic University
City
Hong Kong
Country
Hong Kong

12. IPD Sharing Statement

Plan to Share IPD
No

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Memory Encoding Strategies for People With Mild Cognitive Impairments

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