Back to resultsCRRT for Glutamate Elimination After Cardiac Arrest (GCRRT)
Primary Purpose
Reperfusion Syndrome
Status
Completed
Phase
Not Applicable
Locations
Germany
Study Type
Interventional
Intervention
Continuous renal replacement therapy
Sponsored by
About this trial
This is an interventional treatment trial for Reperfusion Syndrome
Eligibility Criteria
Inclusion Criteria:
- post cardiac arrest
Exclusion Criteria:
- hemodynamic instable
- in-hospital cardiac arrest
Sites / Locations
- Charité-Universitätsmedizin Berlin
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
No Intervention
Arm Label
CRRT after cardiac arrest
control
Arm Description
Continuous renal replacement therapy (CRRT) after cardiac arrest for 72 hours for elimination of Glutamate. Repetitive testing of blood Glutamate levels.
Repetitive testing of blood Glutamate levels without CRRT
Outcomes
Primary Outcome Measures
Glutamate blood concentration in intervention arm over the time
Reduction of blood Glutamate concentration by renal replacement therapy
Secondary Outcome Measures
number of participants with abnormal outcome parameters
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT02963298
Brief Title
CRRT for Glutamate Elimination After Cardiac Arrest
Acronym
GCRRT
Official Title
Pilot Trial Concerning Glutamate Elimination With CRRT for Neurological Outcome After Cardiac Arrest
Study Type
Interventional
2. Study Status
Record Verification Date
June 2019
Overall Recruitment Status
Completed
Study Start Date
October 2016 (undefined)
Primary Completion Date
September 6, 2017 (Actual)
Study Completion Date
September 6, 2017 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor-Investigator
Name of the Sponsor
C. Storm
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
Glutamate is known to be a mediator for apoptosis after brain hypoxia e.g. due to cardiac arrest. This pilot trial evaluates the possibility of elimination of Glutamate by CRRT after cardiac arrest.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Reperfusion Syndrome
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
42 (Actual)
8. Arms, Groups, and Interventions
Arm Title
CRRT after cardiac arrest
Arm Type
Active Comparator
Arm Description
Continuous renal replacement therapy (CRRT) after cardiac arrest for 72 hours for elimination of Glutamate. Repetitive testing of blood Glutamate levels.
Arm Title
control
Arm Type
No Intervention
Arm Description
Repetitive testing of blood Glutamate levels without CRRT
Intervention Type
Procedure
Intervention Name(s)
Continuous renal replacement therapy
Primary Outcome Measure Information:
Title
Glutamate blood concentration in intervention arm over the time
Description
Reduction of blood Glutamate concentration by renal replacement therapy
Time Frame
72 hours
Secondary Outcome Measure Information:
Title
number of participants with abnormal outcome parameters
Time Frame
up to 14 days
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
post cardiac arrest
Exclusion Criteria:
hemodynamic instable
in-hospital cardiac arrest
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Christian Storm, MD
Organizational Affiliation
Charite University, Berlin, Germany
Official's Role
Principal Investigator
Facility Information:
Facility Name
Charité-Universitätsmedizin Berlin
City
Berlin
ZIP/Postal Code
13353
Country
Germany
12. IPD Sharing Statement
Citations:
PubMed Identifier
31557520
Citation
Nee J, Jorres A, Krannich A, Leithner C, Schroeder T, Munk AL, Enghard P, Moore C, Steppan S, Storm C. Elimination of glutamate using CRRT for 72 h in patients with post-cardiac arrest syndrome: A randomized clinical pilot trial. Resuscitation. 2019 Nov;144:54-59. doi: 10.1016/j.resuscitation.2019.09.020. Epub 2019 Sep 23.
Results Reference
derived
Learn more about this trial
CRRT for Glutamate Elimination After Cardiac Arrest
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