A Randomized Controlled Trial in Women With Coronary Artery Disease Investigating the Effects of Aerobic Interval Training Versus Moderate Intensity Continuous Exercise (CAT vs MICE)
Coronary Artery Disease
About this trial
This is an interventional prevention trial for Coronary Artery Disease focused on measuring Aerobic Interval Training, Fitness, Endothelial Function, Cognition
Eligibility Criteria
Inclusion Criteria:
- Post-menopausal women with CAD
- In sinus rhythm
- Left Ventricular Ejection fraction>35%
- >3 weeks post myocardial infarction (MI) or percutaneous intervention (PCI)
- >4 weeks post coronary artery bypass graft (CABG)
- Ability to provide written and informed consent
Exclusion Criteria:
- Any major musculoskeletal, pulmonary, or psychiatric comorbidity that precludes participation in aerobic and resistance training exercise
- Canadian Cardiovascular Society (CCS) contraindications that present upon initial intake Cardiopulmonary Exercise Assessment (CPA), which include Class II-IV angina, significant arrhythmia, or >1mm horizontal/downsloping ST-segment depression.
Sites / Locations
- University Health Network Cardiac Rumsey Centre
Arms of the Study
Arm 1
Arm 2
Experimental
No Intervention
AIT Group
MICE Group
The AIT Group will perform usual care CR exercise for the 1st month of the program. This includes performing aerobic exercise 5 times/week and resistance training twice/week (offered 2 weeks after program start). In month two, this group will begin to perform AIT three days/week, along with two MICE and two RT sessions. The AIT exercise protocol includes the following components: Warm Up Period: 5-10 minutes of walking performed at an intensity that will feel fairly light. Heart rate monitors and watches will be used to gauge their effort. Intervals: Between two to four 4-minute intervals of walking/jogging performed at an intensity that is close to participants' maximal effort, based on the exercise tests that were performed at the beginning of the program. These "hard intervals" will be separated by 3-minutes of active recovery performed at a very light intensity. Cool Down Period: 5 minutes of walking performed at a fairly light intensity.
This group will perform usual care CR for 6 months, which includes both resistance and aerobic exercise (MICE) training. Aerobic exercise is prescribed in the first exercise class and performed 5 times/week, the resistance training program is offered after 2 weeks in the program and performed 2 times/week. Participants will be asked to keep a record of the exercise that they do. Resistance/Strength Training: Patients will be performing 1-2 sets of 5 to 10 resistance training exercises using a combination of hand-held dumbbells, elastic bands of varying thicknesses, as well as their own body weight for resistance. Aerobic Training: Patients will have their aerobic exercise prescription set at an intensity and duration that will be comfortable for them, based on the tests conducted at the beginning of the program to ensure their safety.