Neoadjuvant Chemotherapy Verse Surgery Alone After Stent Placement for Obstructive Colonic Cancer (NACSOC)
Primary Purpose
Colorectal Cancer, Neoadjuvant Chemotherapy, Stent
Status
Recruiting
Phase
Not Applicable
Locations
China
Study Type
Interventional
Intervention
Stenting with neoadjuvant chemotherapy
Stenting with immediate Surgery
Sponsored by
About this trial
This is an interventional treatment trial for Colorectal Cancer
Eligibility Criteria
Inclusion Criteria:
- Radiologically proven colonic obstruction of the left colon/upper rectum presumed secondary to a carcinoma
- Able to give written, informed consent
- Primary tumor was resectable
- ECOG score 0 or 1
- Haemoglobin greater than 100 g/L after transfusion before chemotherapy,
- White blood cells greater than 3.0×10⁹ /L
- Platelets greater than 100×10⁹ / L;
- Glomerular filtration rate greater than 50 mL per minute as calculated by the Wright or Cockroft formula
- Bilirubin less than 1.5×Upper Limit of Normal(ULN)
- ALT and AST less than 2.5×ULN
Exclusion Criteria:
- Distal rectal cancers(equal or less than 10cm from the anal verge)
- Patients with signs of peritonitis and/or bowel perforation
- Patients who did not give informed consent
- Patients who were considered unfit for operative treatment or refuse surgery.
- Patients with suspected or proven metastatic adenocarcinoma;
- Patients with unresectable colorectal cancer, or planning for palliative treatment.
Sites / Locations
- Beijing Chaoyang Hospital, Capital Medical UniversityRecruiting
- Beijing Friendship HospitalRecruiting
- Beijing HospitalRecruiting
- Chinese People's Liberation Army General HospitalRecruiting
- Xuanwu Hospital Capital Medical UniversityRecruiting
- Department of Colorectal Surgery, Cancer Hospital, Chinese Academy of Medical SciencesRecruiting
- the Sixth Affiliated Hospital of Sun Yat-Sen UniversityRecruiting
- the First Affiliated Hospital of Guangxi Medical UniversityRecruiting
- Fourth Hospital of Hebei Medicial UniversityRecruiting
- First Affiliated Hospital of Jiamusi UniversityRecruiting
- the 150th Central Hospital of Chinese PLARecruiting
- the First Affiliated Hospital of Zhengzhou UniversityRecruiting
- the Second Affiliated Hospital of Zhengzhou UniversityRecruiting
- Hubei Cancer HospitalRecruiting
- Hubei General HospitalRecruiting
- Zhongnan Hospital of Wuhan UniversityRecruiting
- the Third Xiangya Hospital of Central South UniversityRecruiting
- Hunan Provincial People'S HospitalRecruiting
- China-Japan Union Hospital of Jilin UniversityRecruiting
- Shengjing Hospital of China Medical UniversityRecruiting
- the First Affiliated Hospital of Dalian Medical UniversityRecruiting
- Shandong Provincial Qianfoshan HospitalRecruiting
- Shandong General HospitalRecruiting
- Qilu Hospital of Shandong UniversityRecruiting
- the Affiliated Hospital of Qingdao UniversityRecruiting
- Changhai HospitalRecruiting
- Shanxi Tumor HospitalRecruiting
- the First Affiliated Hospital of Xi'An Jiaotong UniversityRecruiting
- West China Hospital Sichuan UniversityRecruiting
- the First Affiliated Hospital of Zhejiang UniversityRecruiting
- Jinhua Hospital of Zhejiang UniversityRecruiting
- the Second Affiliated Hospital of Wenzhou Medical UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
Stenting with neoadjuvant chemotherapy
Stenting with Immediate Surgery
Arm Description
After clinical success of colonic stenting, patients will receive neoadjuvant chemotherapy with mFOLFOX6 regimen for 3 cycles or CapeOx regimen for 2 cycles. Patients will undergo surgery 3-5 weeks after the last cycle of chemotherapy, type and extent of the surgery will be selected by the surgeon.
After clinical success of colonic stenting, patients will undergo surgery 7-14 days after inclusion. Type and extent of the elective surgery will be selected by the surgeon.
Outcomes
Primary Outcome Measures
Disease free survival
Overall survival
Rate of stoma formation
Secondary Outcome Measures
Surgical complication
Including but not limited to: anastomotic leakage, wound infection, intra-abdominal sepsis,perioperative mortality, etc.
Rates of primary colorectal anastomosis
The primary colorectal anastomosis was defined as: the patients received one-stage surgery and colorectal anastomosis.
R0 resection rate
R0 resection is defined as negative resection margins and no residual tumor.
Re-operation rate
Chemotherapy complete rate
Chemotherapy related complication
Full Information
NCT ID
NCT02972541
First Posted
September 8, 2016
Last Updated
February 4, 2021
Sponsor
Beijing Chao Yang Hospital
1. Study Identification
Unique Protocol Identification Number
NCT02972541
Brief Title
Neoadjuvant Chemotherapy Verse Surgery Alone After Stent Placement for Obstructive Colonic Cancer
Acronym
NACSOC
Official Title
NeoAdjuvant Chemotherapy Versus Surgery Alone After Stent Placement for Left-sided Obstructive Colonic Cancer:a Multicenter, Controlled, Open-label Clinical Trial (NACSOC Trial)
Study Type
Interventional
2. Study Status
Record Verification Date
February 2021
Overall Recruitment Status
Recruiting
Study Start Date
September 30, 2016 (undefined)
Primary Completion Date
December 30, 2023 (Anticipated)
Study Completion Date
December 30, 2023 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Beijing Chao Yang Hospital
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
Colorectal cancer is the fourth most common cancer in China. Up to 30% of patients with colorectal cancer present with an emergency obstruction of the large bowel at the time of diagnosis, and 70% of all malignant obstruction occurs in the left-sided colon. Patients with obstruction are associated with worse oncologic outcomes compared with those having nonobstructive tumors. Conventionally, patients with malignant large bowel obstruction receive emergency surgery, with morbidity rates of 30%-60% and mortality rates of 7-22%, and about two-thirds of such patients end up with a permanent stoma.
Self-expanding metallic stents (SEMS) haven been used as a bridge to surgery (to relieve obstruction prior to elective surgery) in patients with potentially resectable colorectal cancer. Several clinical trials demonstrate that SEMS as a bridge to surgery may be superior to emergency surgery considering the short-term outcomes. SEMS is associated with lower morbidity and mortality rate, increased primary anastomosis rate, and decreased stoma creation rate. Although about half of patients can achieve primary anastomosis after stent placement, the primary anastomosis rate is still significantly lower compared with nonobstructing elective surgery. The interval between stent placement and surgery may be not long enough that bowel decompression is insufficient at the time of operation. Furthermore,the long-term oncologic results regarding SEMS as a bridge to surgery are still limited and contradictory. Sabbagh et al. suggest worse overall survival of patients with SEMS insertion compared with emergency surgery, the 5-year cancer-specific mortality was significantly higher in the SEMS group (48% vs 21%, respectively, P=0.02). One interpretation is that tumor cells may disseminate during the procedure of colonic stenting placement. We hypothesis that immediate chemotherapy after stenting may improve overall survival by eradicating micrometastasis. Moreover, neoadjuvant chemotherapy prolongs the interval between stent placement and surgery, and the time for bowel decompression is more sufficient, which may increase the success rate of primary anastomosis and decrease risk of stoma formation.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Colorectal Cancer, Neoadjuvant Chemotherapy, Stent, Obstruction
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
248 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Stenting with neoadjuvant chemotherapy
Arm Type
Experimental
Arm Description
After clinical success of colonic stenting, patients will receive neoadjuvant chemotherapy with mFOLFOX6 regimen for 3 cycles or CapeOx regimen for 2 cycles. Patients will undergo surgery 3-5 weeks after the last cycle of chemotherapy, type and extent of the surgery will be selected by the surgeon.
Arm Title
Stenting with Immediate Surgery
Arm Type
Active Comparator
Arm Description
After clinical success of colonic stenting, patients will undergo surgery 7-14 days after inclusion. Type and extent of the elective surgery will be selected by the surgeon.
Intervention Type
Device
Intervention Name(s)
Stenting with neoadjuvant chemotherapy
Intervention Description
After clinical success of colonic stenting, patients will be given neoadjuvant chemotherapy. Surgery is performed after 3 cycles of mFOLFOX6 or 2 cycles of CapeOx. The choice of surgery performed is up to the individual consultant colorectal surgeon. Patients will receive 5-9 cycles of mFOLFOX6 or 4-6 cycles of CapeoX after surgery. Each cycle of mFOLFOX6 consists of racemic leucovorin 400 mg/m², oxaliplatin 85 mg/m² in a 2-h infusion, bolus fluorouracil 400 mg/m² on day 1, and a 46-h infusion of fluorouracil 2400 mg/m². Each cycle of CapeOx consists of oxaliplatin 130 mg/m2, capecitabine 100 mg/m2 twice daily for 14 days.
Intervention Type
Device
Intervention Name(s)
Stenting with immediate Surgery
Intervention Description
After clinical success of colonic stenting, patients will undergo surgery 7-14 days later. The choice of surgery performed is up to the individual consultant colorectal surgeon. Patients will receive 8-12 cycles of mFOLFOX6 or 6-8 cycles of CapeoX after surgery. Each cycle of mFOLFOX6 consists of racemic leucovorin 400 mg/m², oxaliplatin 85 mg/m² in a 2-h infusion, bolus fluorouracil 400 mg/m² on day 1, and a 46-h infusion of fluorouracil 2400 mg/m². Each cycle of CapeOx consists of oxaliplatin 130 mg/m2, capecitabine 100 mg/m2 twice daily for 14 days.
Primary Outcome Measure Information:
Title
Disease free survival
Time Frame
From date of randomization until the date of tumor recurrence or death from any cause, assessed up to 5 years
Title
Overall survival
Time Frame
From date of randomization until the date of death from any cause, assessed up to 5 years
Title
Rate of stoma formation
Time Frame
From date of randomization until the follow-up ended, assessed up to 5 years
Secondary Outcome Measure Information:
Title
Surgical complication
Description
Including but not limited to: anastomotic leakage, wound infection, intra-abdominal sepsis,perioperative mortality, etc.
Time Frame
From date of randomization until the first follow-up ended, assessed up to 30 days
Title
Rates of primary colorectal anastomosis
Description
The primary colorectal anastomosis was defined as: the patients received one-stage surgery and colorectal anastomosis.
Time Frame
From date of randomization until the first follow-up ended, assessed up to 30 days
Title
R0 resection rate
Description
R0 resection is defined as negative resection margins and no residual tumor.
Time Frame
From date of randomization until the first follow-up ended, assessed up to 30 days
Title
Re-operation rate
Time Frame
From date of randomization until the follow-up ended, assessed up to 5 years
Title
Chemotherapy complete rate
Time Frame
From date of randomization until the chemotherapy ended, assessed up to 1 years
Title
Chemotherapy related complication
Time Frame
From date of randomization until the chemotherapy ended, assessed up to 1 years
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Radiologically proven colonic obstruction of the left colon/upper rectum presumed secondary to a carcinoma
Able to give written, informed consent
Primary tumor was resectable
ECOG score 0 or 1
Haemoglobin greater than 100 g/L after transfusion before chemotherapy,
White blood cells greater than 3.0×10⁹ /L
Platelets greater than 100×10⁹ / L;
Glomerular filtration rate greater than 50 mL per minute as calculated by the Wright or Cockroft formula
Bilirubin less than 1.5×Upper Limit of Normal(ULN)
ALT and AST less than 2.5×ULN
Exclusion Criteria:
Distal rectal cancers(equal or less than 10cm from the anal verge)
Patients with signs of peritonitis and/or bowel perforation
Patients who did not give informed consent
Patients who were considered unfit for operative treatment or refuse surgery.
Patients with suspected or proven metastatic adenocarcinoma;
Patients with unresectable colorectal cancer, or planning for palliative treatment.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
zhenjun wang, MD
Phone
8610-85231604
Email
drzhenjun@163.com
First Name & Middle Initial & Last Name or Official Title & Degree
weigen zeng, MD
Phone
8610-85231604
Email
shen_coco@163.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
zhenjun wang, MD
Organizational Affiliation
Beijing Chao Yang Hospital
Official's Role
Principal Investigator
Facility Information:
Facility Name
Beijing Chaoyang Hospital, Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100020
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Zhen Jun Wang, M.D.
Phone
86-013601393711
Email
drzhenjun@163.com
First Name & Middle Initial & Last Name & Degree
Zhen Jun Wang
Facility Name
Beijing Friendship Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100020
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
zhongtao zhang, MD
Phone
8610-63016616
Email
yaohongwei@medmail.com.cn
Facility Name
Beijing Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100020
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
gang xiao, MD
Phone
8610-85132266
Email
xgbj@sina.com
Facility Name
Chinese People's Liberation Army General Hospital
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100020
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
xiaohui du, MD
Email
duxiaohui301@sina.com
Facility Name
Xuanwu Hospital Capital Medical University
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100020
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
fei li, MD
Email
feili36@ccmu.edu.cn
Facility Name
Department of Colorectal Surgery, Cancer Hospital, Chinese Academy of Medical Sciences
City
Beijing
State/Province
Beijing
ZIP/Postal Code
100021
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
xi-shan wang, MD
Phone
8610-87787110
Email
794157254@qq.com
Facility Name
the Sixth Affiliated Hospital of Sun Yat-Sen University
City
Guangzhou
State/Province
Guangdong
ZIP/Postal Code
510655
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
lei wang, MD
Phone
8620-38254011
Email
wangl9@mail.sysu.edu.cn
Facility Name
the First Affiliated Hospital of Guangxi Medical University
City
Nanjing
State/Province
Guangxi
ZIP/Postal Code
530021
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
wei-zhong tang, MD
Email
13978157758@163.com
Facility Name
Fourth Hospital of Hebei Medicial University
City
Shijiazhuang
State/Province
Hebei
ZIP/Postal Code
050011
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
guiying wang, MD
Phone
86311-86095588
Email
tizq12@vip.163.com
Facility Name
First Affiliated Hospital of Jiamusi University
City
Jiamusi
State/Province
Heilongjiang
ZIP/Postal Code
154003
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
fujun chen, MD
Email
gck8801079@163.com
Facility Name
the 150th Central Hospital of Chinese PLA
City
Luoyang
State/Province
Henan
ZIP/Postal Code
471031
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
dong wei
Facility Name
the First Affiliated Hospital of Zhengzhou University
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
weitang yuan, MD
Email
13978157758@163.com
Facility Name
the Second Affiliated Hospital of Zhengzhou University
City
Zhengzhou
State/Province
Henan
ZIP/Postal Code
450014
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
zhigang pang, MD
Email
pzg63726@sina.com
Facility Name
Hubei Cancer Hospital
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
keliang zhang, MD
Phone
8627-87670242
Email
13071238088@163.com
Facility Name
Hubei General Hospital
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430060
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
shilun tong, MD
Email
tongshilun@163.com
Facility Name
Zhongnan Hospital of Wuhan University
City
Wuhan
State/Province
Hubei
ZIP/Postal Code
430071
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
qun qian, MD
Phone
86-013098824999
Email
qunqian2007@163.com
Facility Name
the Third Xiangya Hospital of Central South University
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
xiaorong li, MD
Email
lixiaorong@medmail.com
Facility Name
Hunan Provincial People'S Hospital
City
Changsha
State/Province
Hunan
ZIP/Postal Code
410005
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
zhongcheng huang, MD
Phone
86731-83929555
Email
huangzc369@163.com
Facility Name
China-Japan Union Hospital of Jilin University
City
Changchun
State/Province
Jilin
ZIP/Postal Code
130033
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
tongjun liu, MD
Email
tongjunliu@163.com
Facility Name
Shengjing Hospital of China Medical University
City
Shenyang
State/Province
Liaoning
ZIP/Postal Code
110004
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
yong feng, MD
Email
fengy@sj-hospital.org
Facility Name
the First Affiliated Hospital of Dalian Medical University
City
Dalian
State/Province
Shandong
ZIP/Postal Code
116011
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
wei bi, MD
Facility Name
Shandong Provincial Qianfoshan Hospital
City
Jinan Shi
State/Province
Shandong
ZIP/Postal Code
250014
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
lijian xia, MD
Email
xiaalbert2758@163.com
Facility Name
Shandong General Hospital
City
Jinan Shi
State/Province
Shandong
ZIP/Postal Code
250021
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
changqing jing, MD
Email
jing66510122@sina.com
Facility Name
Qilu Hospital of Shandong University
City
Jinan
State/Province
Shandong
ZIP/Postal Code
250022
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Yong Dai, M.D.
Email
18560085128@163.com
Facility Name
the Affiliated Hospital of Qingdao University
City
Qingdao
State/Province
Shandong
ZIP/Postal Code
266000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
yun lu, MD
Email
cloudylucn@126.com
Facility Name
Changhai Hospital
City
Shanghai
State/Province
Shanghai
ZIP/Postal Code
200000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
chuangang fu, MD
Email
fugang416@126.com
Facility Name
Shanxi Tumor Hospital
City
Taiyuan
State/Province
Shanxi
ZIP/Postal Code
030013
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
xiaobo liang, MD
Phone
860351-4651714
Email
liangxiaobo@medmail.com.cn
Facility Name
the First Affiliated Hospital of Xi'An Jiaotong University
City
Xi'an
State/Province
Shanxi
ZIP/Postal Code
710061
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
xiangming che, MD
Email
chexiang@mail.xjtu.edu.cn
Facility Name
West China Hospital Sichuan University
City
Chengdu
State/Province
Sichuan
ZIP/Postal Code
610041
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
zi-qiang wang, MD
Email
wangzqzyh@163.com
Facility Name
the First Affiliated Hospital of Zhejiang University
City
Hangzhou
State/Province
Zhejiang
ZIP/Postal Code
310003
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
jianjiang lin, MD
Email
ljjzju@163.com
Facility Name
Jinhua Hospital of Zhejiang University
City
Jinhua
State/Province
Zhejiang
ZIP/Postal Code
321000
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
jinlin du, MD
Email
djl9090@163.com
Facility Name
the Second Affiliated Hospital of Wenzhou Medical University
City
Wenzhou
State/Province
Zhejiang
ZIP/Postal Code
325027
Country
China
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
changbao liu, MD
Email
lcb@wzhealth.com
12. IPD Sharing Statement
Plan to Share IPD
No
Citations:
PubMed Identifier
23324856
Citation
Sabbagh C, Browet F, Diouf M, Cosse C, Brehant O, Bartoli E, Mauvais F, Chauffert B, Dupas JL, Nguyen-Khac E, Regimbeau JM. Is stenting as "a bridge to surgery" an oncologically safe strategy for the management of acute, left-sided, malignant, colonic obstruction? A comparative study with a propensity score analysis. Ann Surg. 2013 Jul;258(1):107-15. doi: 10.1097/SLA.0b013e31827e30ce.
Results Reference
background
PubMed Identifier
21398178
Citation
van Hooft JE, Bemelman WA, Oldenburg B, Marinelli AW, Lutke Holzik MF, Grubben MJ, Sprangers MA, Dijkgraaf MG, Fockens P; collaborative Dutch Stent-In study group. Colonic stenting versus emergency surgery for acute left-sided malignant colonic obstruction: a multicentre randomised trial. Lancet Oncol. 2011 Apr;12(4):344-52. doi: 10.1016/S1470-2045(11)70035-3. Erratum In: Lancet Oncol. 2011 May;12(5):418.
Results Reference
background
PubMed Identifier
26252845
Citation
Young CJ, De-Loyde KJ, Young JM, Solomon MJ, Chew EH, Byrne CM, Salkeld G, Faragher IG. Improving Quality of Life for People with Incurable Large-Bowel Obstruction: Randomized Control Trial of Colonic Stent Insertion. Dis Colon Rectum. 2015 Sep;58(9):838-49. doi: 10.1097/DCR.0000000000000431.
Results Reference
background
PubMed Identifier
24170606
Citation
Huang X, Lv B, Zhang S, Meng L. Preoperative colonic stents versus emergency surgery for acute left-sided malignant colonic obstruction: a meta-analysis. J Gastrointest Surg. 2014 Mar;18(3):584-91. doi: 10.1007/s11605-013-2344-9. Epub 2013 Oct 30.
Results Reference
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PubMed Identifier
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Citation
Ohman U. Prognosis in patients with obstructing colorectal carcinoma. Am J Surg. 1982 Jun;143(6):742-7. doi: 10.1016/0002-9610(82)90050-2.
Results Reference
background
PubMed Identifier
19363580
Citation
Kim JS, Hur H, Min BS, Sohn SK, Cho CH, Kim NK. Oncologic outcomes of self-expanding metallic stent insertion as a bridge to surgery in the management of left-sided colon cancer obstruction: comparison with nonobstructing elective surgery. World J Surg. 2009 Jun;33(6):1281-6. doi: 10.1007/s00268-009-0007-5.
Results Reference
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PubMed Identifier
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Citation
Han J, Wang Z, Dai Y, Li X, Qian Q, Wang G, Wei G, Zeng W, Ma L, Zhao B, Wang Y, Yang K, Ding Z, Hu X. [Preliminary report on prospective, multicenter, open research of selective surgery after expandable stent combined with neoadjuvant chemotherapy in the treatment of obstructive left hemicolon cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2018 Nov 25;21(11):1233-1239. Chinese.
Results Reference
derived
Learn more about this trial
Neoadjuvant Chemotherapy Verse Surgery Alone After Stent Placement for Obstructive Colonic Cancer
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