Anesthesia Depth's Influence on Postoperative Delirium
Femur Head Necrosis
About this trial
This is an interventional prevention trial for Femur Head Necrosis focused on measuring depth of anesthesia\postoperation delirium
Eligibility Criteria
Inclusion Criteria:
- participant who is selected to undergo hip replacement surgery.
- participant who is older than 60 years old.
- participant whose ASA(The American Society of Anesthesiologists) is II-III.
- participant whose BMI is 18-25.
- participant who is able to understand and complete The Confusion Assessment Method(CAM-CR).
- participant who is able to finish Visual Analogue Scale(VAS).
- participant who is conscious and willing to take part in this research.
- participant and his/her relatives are willing to take part in this research.
Exclusion Criteria:
- participant who has serious liver or kidney disease.
- participant who suffer from mental or neurologic disease,such as Alzheimer disease.
- participant who has undergone cardiovascular surgery or neurosurgery.
- participant who has have sedation or antidepression medicine for a long time.
- participant who has something wrong with his/her vision or hearing.
- participant who has blood coagulation dysfunction.
- participant who is an illiteracy.
Sites / Locations
- Xiangya hospital of CSU
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
L Group
D Group
The participants in L Group will receive Lumbar plexus and sciatic nerve block with ropivacaine before anesthesia induction.The investigator use Diprivan TCI target-controlled infusion during anesthesia induction period, target effect-site concentration is set at 4.0g / kg. After reaching the target concentration, sufentanil 0.2g / kg is administrated, Laryngeal mask will be placed into participant's mouth at 2 min after sufentanil is given. Anesthesia will be maintained with remifentanil TCI target-controlled infusion and Diprivan BIS close-loop target controlled infusion,BIS ranges from 50 to 60.The values of BP,P,PetCO2 will be controled in proper site. each participant will be given postoperative analgesia pump to release postoperative pain.
The participant in L Group will receive Lumbar plexus and sciatic nerve block with ropivacaine before anesthesia induction.The investigator use Diprivan TCI target-controlled infusion during anesthesia induction period, target effect-site concentration is set at 4.0g / kg. After reaching the target concentration, sufentanil 0.2g / kg is administrated, Laryngeal mask will be placed into participant's mouth at 2 min after sufentanil is given. Anesthesia will be maintained with remifentanil TCI target-controlled infusion and Diprivan BIS close-loop target controlled infusion,BIS ranges from 35 to 45.The values of BP,P,PetCO2 will be controled in proper site. The investigator use postoperative analgesia pump to control postoperative pain for each participant.