Emotional Lived in Patients Suffering From Psychogenic Nonepileptic Seizures : Study by Functional Magnetic Resonance Imaging (EMOCRISES)
Psychogenic Non-epileptic Seizures
About this trial
This is an interventional other trial for Psychogenic Non-epileptic Seizures
Eligibility Criteria
Common Inclusion Criteria:
- Female,
- Right-handed
- Affiliation to the French social security system,
- Informed signing of the study consent.
Specific Inclusion Criteria for PNES group :
- PNES diagnosed by a neurologist specialized in epilepsy, based on clinical symptoms analysis and video-EEG recording,
- Absence of concomitant epilepsy.
Specific Inclusion Criteria for PTSD group : PTSD diagnosed by a psychiatrist, based on clinical symptoms as recorded in DSM5 (Diagnostic and Statistical Manual of Mental Disorders).
Specific Inclusion Criteria for healthy controls : Healthy controls will be paired up with patients on age and level of schooling criteria.
Exclusion Criteria:
common criteria for all groups:
- Neurological history or comorbidity (epilepsy included),
- Current neurological treatment,
- Posology change or introduction of psychoactive treatment dating back to less than a month,
- Psychotic comorbidity (schizophrenia),
- Addiction history apart for smoking,
- History of head trauma,
- Mental retardation,
- Being the subject of articles L.1121-5 to L.1121-8 and L1122-1-2 of the French Code of Public Health (i.e. being a not responsible adult),
- Lack of French language proficiency or inability to understand instructions,
- Uncorrected visual impairment,
- Any contraindication to MRI (pacemaker, ferromagnetic foreign body, claustrophobia, etc.).
Specific exclusion Criteria for PNES group : Diagnosis of PNES challenged or denied by the patient.
Specific exclusion Criteria for PTSD group :
- Diagnosis of PTSD challenged or denied by the patient, current or history of functional neurological symptom disorder,
- History of PNES (conversion disorder).
Specific exclusion Criteria for healthy controls :
- History of PTSD,
- History of PNES (conversion disorder).
Sites / Locations
- CHRU de NancyRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Other
Other
PNES
PTSD
Healthy controls
Psychogenic Non-epileptic Seizures subjects
Post Traumatic Stress Disorder
Healthy controls