A Dose Finding Study Followed by a Safety and Efficacy Study for Patients With Multiple Myeloma or Lymphoma
Multiple Myeloma, NonHodgkin Lymphoma
About this trial
This is an interventional treatment trial for Multiple Myeloma focused on measuring Multiple Myeloma, Relapsed/Refractory, Lymphoma, Non-Hodgkin Lymphoma, Diffuse Large B-Cell Lymphoma, DLBCL, Mantle Cell Lymphoma, MCL, Peripheral T-Cell Lymphoma, PTCL, TAS4464, NEDD8, NAE inhibitor, Neoplasms, Hematologic Diseases, Myeloma
Eligibility Criteria
Inclusion Criteria:
- Provide written informed consent
- Women of child-bearing potential must have a negative pregnancy test
Multiple Myeloma:
Confirmed diagnosis of Multiple Myeloma with measurable disease, having been treated with at least two prior lines of therapy.
Lymphoma:
Confirmed diagnosis of Non-Hodgkin Lymphoma with measurable disease, having been treated with at least one anthracycline-based therapy, with relapse or progression since the last treatment received.
Exclusion Criteria:
Any of the following treatments, within the specified time frame, prior to the first dose of TAS4464:
- Major surgery within 28 days
- Radiation/chemotherapy within 21 days
- Monoclonal antibodies within 28 days
- Corticosteroid administration >20 mg/day of prednisone or equivalent within 14 days
- Proteasome inhibitors within 14 days
- Immunomodulatory agents within 7 days
- Stem cell transplant within 3 months
- Current immunosuppressive treatment for graft versus host disease
- Current use of an investigational agent
- Active graft versus host disease
- Known serious illness or medical condition
- Prior treatment with TAS4464 or known hypersensitivity to any of its inactive ingredients or drugs similar in class
- Pregnant or breast-feeding female
Sites / Locations
- Center for Cancer and Blood Disorders
- Dana-Farber Cancer Institute
- Weisberg Cancer Treatment Center
- Mayo Clinic
- John Theurer Cancer Center at Hackensack Meridian Health
- Icahn School of Medicine at Mount Sinai
- Gabrail Cancer Center
Arms of the Study
Arm 1
Experimental
TAS4464