Quartet Lead With Defibrillator Multisite Algorithmic Cardiac Resynchronisation Therapy Optimisation (QUARTRMASTER)
Heart Failure, Systolic
About this trial
This is an interventional treatment trial for Heart Failure, Systolic focused on measuring Cardiac resynchronization pacing therapy
Eligibility Criteria
Inclusion Criteria:
- Successful implantation of CRT-D device with quadripolar left ventricular lead and dual coil right ventricular lead.
Exclusion Criteria:
- failed device implantation
- inability to complete the follow-up process
- inability to provide full written consent. Patients unable to perform cardiopulmonary exercise testing will be excluded from this assessment only and will be able to complete the remaining assessments.
Sites / Locations
- University Hospital of Wales
Arms of the Study
Arm 1
Experimental
Main patient cohort
Algorithmic Cardiac Resynchronisation Therapy Optimisation; Patients requiring CRT-D enrolled to receive algorithmic CRT optimisation at their device implantation. They will then be programmed to standard CRT settings for 12 weeks. Assessments will be performed and they will again undergo CRT optimisation using the specified algorithm. This time, they will be programmed to the settings giving maximal cardiac output on echocardiography, as assessed by LVOT VTI. After a further 12 weeks, they will again undergo assessment and the study will terminate.