Optimal Growth of Preterm Infants With Growth Restriction (OPTIGROW)
Growth Failure, Adiposity, Diabetes
About this trial
This is an interventional treatment trial for Growth Failure focused on measuring preterm infants, SGA infants, IUGR infants, growth, body composition, metabolomics, microbiome, adiposity markers, metabolic programming, neurodevelopmental outcome
Eligibility Criteria
Inclusion Criteria:
- Preterm infants with a birth weight <1500g and birth weight <10th percentile.
- Weight at term <10th percentile
- Informed consent
Exclusion Criteria:
- Genetic or metabolic diseases with the primary effect on growth
- Necrotizing enterocolitis
- Intraventricular hemorrhage (IVH) >Grade II
- Periventricular leukomalacia (PVL) Stage III
- Genetic or metabolic disorders
- Bronchopulmonary dysplasia
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Other
Active Comparator
Other
SGA-enhanced nutrients
SGA-standard nutrients
IUGR-enhanced nutrients
IUGR-standard nutrients
Infants will receive fortified breast milk (>50% meals/d fortified, 1,4 g protein, 85 kcal/100ml, FM85, Nestle ®) or post discharge formula (2g protein; 73-75 kcal/100ml; Aptamil PDF, Milupa® or Beba F Nestle® ) between discharge and 52nd week of gestation (three months after term)
Infants will receive unfortified breast milk (65-70kcal/100ml) or starter formula (1,2- 1,3g protein, 66 kcal/100ml Beba Pre Pro Start, Nestle® or Aptamil Pre, Milupa ®) between discharge and 52nd week of gestation (three months after term).
Infants will receive fortified breast milk (>50% meals/d fortified, 1,4 g protein, 85 kcal/100ml, FM85, Nestle ®) or post discharge formula (2g protein; 73-75 kcal/100ml; Aptamil PDF, Milupa® or Beba F Nestle® ) between discharge and 52nd week of gestation (three months after term
Infants will receive unfortified breast milk (65-70kcal/100ml) or starter formula (1,2- 1,3g protein, 66 kcal/100ml Beba Pre Pro Start, Nestle® or Aptamil Pre, Milupa ®) between discharge and 52nd week of gestation (three months after term).