Cortical Modulation of Acute Post-thoracotomy Pain With Transcranial Direct Current Stimulation (CMAPTPtDCS)
Pain, Postoperative
About this trial
This is an interventional treatment trial for Pain, Postoperative focused on measuring Transcranial Direct Current Stimulation, Pain Postoperative, Thoracotomy
Eligibility Criteria
Inclusion Criteria:
- Subject is willing and able to provide written informed consent,
- Subject is 18-80 years old,
- Subject needs thoracotomy for confirmed malignant lung disease,
- Subject is extubated in the operating room
Exclusion Criteria:
- Subject is pregnant
- Subject is in treatment for psychiatric disease
- Subject is in treatment for neurological disease
- Subject is in treatment for chronic pain
- Subject has history of current or past alcohol or Street Drug abuse
- Subject has received chemotherapy
- Subject has history of previous thoracic or cardiac surgery
- Subject is allergic to medications that will be used in the study
- Subject has pacemaker or automatic implantable cardioverter/defibrillator
- Subject has implants or any other devices in the head, the spinal cord or peripheral nerves
- Subject has confirmed brain lesion, including tumor or metastasis
Sites / Locations
- Military Medical Academy, Department of Anesthesiology
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Active tDCS
Sham tDCS
Experimental: Transcranial direct current stimulation (tDCS). Patients assigned to the active treatment group (n=31) will receive IV morphine followed by IV morphine PCA (IV morphine bolus 1 mg, lockout time 10 mins.), preceded by tDCS (20 minutes of 2 milliamperes (mA) anodal tDCS over the ipsilateral cortex for 5days/week).
Sham Control Group: Patients assigned to the control group (n=31) will receive IV morphine followed by IV morphine PCA (IV morphine bolus 1 mg, lockout time 10 mins.), preceded by sham tDCS stimulation (30 sec over the ipsilateral cortex, 5 days/week).