The Effect of Desflurane vs Sevoflurane on Perioperative Respiratory Complications in Laryngeal Mask Airway Anesthesia
Anesthesia; Adverse Effect, Laryngeal Masks, Respiratory System Abnormalities
About this trial
This is an interventional diagnostic trial for Anesthesia; Adverse Effect focused on measuring Desflurane, Sevoflurane, Respiratory Complications
Eligibility Criteria
Inclusion criteria:
- Patients with American Society of Anesthesiologists physical status classification of I-III
- Elective surgery
- Surgery with expected duration of operation of less than 2 hours
- Surgery that anesthesiologist plans to use laryngeal mask airway during anesthesia
Exclusion Criteria:
- Patients with gastroesophageal reflux disease
- Patients with hiatal hernia
- Patients with history of upper respiratory tract infection within 1 month before surgery
- Heavy smoker (> 20 cigarettes per day)
- Obese patients with body mass index > 30kg/m2
- Pregnant patients
- Unable to provide a written informed consent patients
- Surgery requiring non-depolarizing muscle relaxants
Sites / Locations
- Chiang Mai UniversityRecruiting
- Chiang Mai UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Desflurane
Sevoflurane
Desflurane group: The rule of 24 will be applied, which means that the fresh gas flow (l/ min) multiplied by volume percent of desflurane must not exceed 24. Therefore, once the patients return of spontaneous ventilation, an anesthesiologist turns on oxygen 1 l/ min, nitrous oxide 1 l/ min, and desflurane 12 vol% for 1-2 minutes. When the end-tidal desflurane reaches 3-3.5% (approximately 0.5 MAC), the anesthesiologist will decrease oxygen and nitrous oxide to each 0.5 l/ min and desflurane to 6 vol% (1 MAC). Desflurane concentration will be adjusted to maintain the end-tidal desflurane around 3-6% (0.5-1 MAC).
Sevoflurane group: The oxygen and nitrous oxide each 1 l/min will be turned on with sevoflurane 4 vol% for 1-2 minutes or until the end-tidal sevoflurane reach 1-1.2% (approximately 0.5 MAC). After that, the flow of oxygen and nitrous oxide is reduced to each 0.5 l/ min and concentration dial of sevoflurane is set to 2 vol% (1 MAC). During the operation, sevoflurane concentration will be adjusted to maintain the end-tidal sevoflurane around 1-2% (0.5-1 MAC)