nHFOV Versus nCPAP in Transient Tachypnea of the Newborn
Transient Tachypnea of the Newborn

About this trial
This is an interventional treatment trial for Transient Tachypnea of the Newborn focused on measuring high frequency oscillatory ventilation, newborn, noninvasive ventilation, transient tachypnea of the newborn
Eligibility Criteria
Inclusion Criteria:
- Gestational age at birth between 34 and 42 weeks of gestation
- Admission to Bursa Yüksek Ihtisas Teaching Hospital, NICU during the first 24 hours of life
- Diagnosis of transient tachypnea of the newborn (TTN) within the first 24 hours of life
Exclusion Criteria:
- Gestational age at birth less than 34 weeks or greater than 42 weeks at birth
- Chest X-ray or lung ultrasound finding indicating another respiratory disorder
- Additional infant diagnosis of major cardiac disease
- Additional infant diagnosis of major pulmonary disease other than TTN
- Additional infant diagnosis of major congenital anomaly with potential to affect respiratory status in the neonatal period
- Additional infant diagnosis of infectious disease process potentially affecting respiratory status in the neonatal period
Sites / Locations
- University of Health Sciences, Bursa Yuksek Ihtisas Teaching HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
nHFOV
nCPAP
Ventilator-derived nHFOV will be administered using binasal prongs. Standard Device: Leoni-Plus or Leoni-2 Ventilator, Heinen Löwenstein, Germany Initial nHFOV settings are: MAP: 8cmH2O, Frequency:10 MHz, Amplitude:35 cmH2O (will be adjusted to achieve adequate chest wall vibration), I:E=1:1 and FiO2: adjusted to keep preductal sPO2 between %90-95. Failure is defined as FiO2 requirement of >%60, capillary blood gas obtained at the 4th hour of therapy showing pH<7.20 or pCO2>65 cmH2O. When nHFOV failure occurs, nasal intermittent positive pressure ventilation (nIPPV) will be applied as a rescue therapy with the following settings: Frequency:30/min, PIP:18 cmH2O, PEEP:6 cmH2O, inspiration time:0.50 sec., inspiratory flow:10 L/min, FiO2:adjusted to keep preductal sPO2 between %90-95.
Ventilator-derived nCPAP will be administered using binasal prongs. Standard Device: Leoni-Plus or Leoni-2 Ventilator, Heinen Löwenstein, Germany Initial nCPAP settings are: PEEP:6 cmH2O and FiO2: adjusted to keep preductal sPO2 between %90-95. Failure is defined as FiO2 requirement of >%60, capillary blood gas obtained at the 4th hour of therapy showing pH<7.20 or pCO2>65 cmH2O. When nCPAP failure occurs, nasal intermittent positive pressure ventilation (nIPPV) will be applied as a rescue therapy with the following settings: Frequency:30/min, PIP:18 cmH2O, PEEP:6 cmH2O, inspiration time:0.50 sec., inspiratory flow:10 L/min, FiO2:adjusted to keep preductal sPO2 between %90-95.